Central bombesin inhibits food intake and the orexigenic effect of neuropeptide Y in the neonatal chick

T. Bungo, R. Ando, S. I. Kawakami, A. Ohgushi, M. Shimojo, Y. Masuda, M. Furuse

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

It is well known that central injection of bombesin (BN) suppresses feeding in mammalian and avian species, but the anorexigenic effect of central BN are still open with special reference to the chick. The dose response (0, 0.1 and 0.5 μg) of intracerebroventricular (ICV) injection of BN was examined in Experiment 1. ICV injection of BN inhibited food intake in a dose-dependent manner. Experiment 2 was done to determine whether BN interacts with the orexigenic effect of neuropeptide Y (NPY) in the neonatal chick. Central administration of NPY (2.5 μg) greatly enhanced food intake, but co-injection of BN (0.5 μg) suppressed food intake. The dose response of NPY (2.5 μg) co-injected with three levels of BN (0, 0.1 and 0.5 μg) was examined in Experiment 3. ICV injection of BN attenuated the hyperphagia by NPY in a dose-related fashion. It is suggested that central BN may interact with NPY for the regulation of feeding in the neonatal chick. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)573-576
Number of pages4
JournalPhysiology and Behavior
Volume70
Issue number5
DOIs
Publication statusPublished - Sep 15 2000

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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