Central, but not peripheral, glucagon-like peptide-1 inhibits crop emptying in chicks

Tetsuya Tachibana, Mako Matsumoto, Mitsuhiro Furuse, Shin Hasegawa, Fumiaki Yoshizawa, Kunio Sugahara

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We investigated the effect of central and peripheral glucagon-like peptide-1 (GLP-1) on crop emptying in growing chicks. Intracerebroventricular injection of two concentrations of GLP-1 (15 and 60 pmol) similarly suppressed crop emptying, compared with control chicks. The delay in crop emptying induced by GLP-1 (15 pmol) was partly attenuated by co-administration with exendin (5-39) (600 pmol), a GLP-1 receptor antagonist, although exendin (5-39) alone did not affect crop emptying. On the other hand, intraperitoneal administration of several doses of GLP-1 (120, 300 and 3000 pmol) did not alter crop emptying. The present study revealed that central, but not peripheral, GLP-1 inhibits crop emptying in chicks.

Original languageEnglish
Pages (from-to)777-781
Number of pages5
JournalComparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Volume134
Issue number4
DOIs
Publication statusPublished - Apr 1 2003

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology

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