Central functions of glutathione, and peptides and amino acids related to glutathione synthesis and metabolism, on stress responses

Mitsuhiro Furuse, D. Michael Denbow

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Glutathione reductase irreversibly catalyzes the reduction from oxidized glutathione to reduced glutathione.Both oxidized glutathione and reduced glutathionedose-dependently decreased distress vocalizations and induced sleep-like behavior in chicks under acute stressful conditions. Energy expenditure was rapidly decreased by intracerebroventricular injection of reduced glutathione, but thenincreased gradually.This change in energy expenditure was correlated with behavioral changes in whichreduced glutathione induced hypnotic and sedative effects shortly after injection, followed by a period where activity increased. There are three types of dipeptides related to reduced glutathione, i.e., glutamyl-cysteine, cysteinyl-glycine and glutamyl-glycine that are theoretically present in tissues.These peptides also attenuated distress vocalizations and spontaneous activity induced by social isolationand did not vary in their action from each other.Reduced glutathione is a tripeptide which consists of L-glutamate, L-cysteine and glycine. All three amino acids induced sedative and hypnotic effects.In conclusion, glutathione and its constituents are helpful to ameliorating an acute stressful condition.

Original languageEnglish
Title of host publicationGlutathione
Subtitle of host publicationBiochemistry, Mechanisms of Action and Biotechnological Implications
PublisherNova Science Publishers, Inc.
Pages35-53
Number of pages19
ISBN (Print)9781624174605
Publication statusPublished - Feb 1 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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    Furuse, M., & Michael Denbow, D. (2013). Central functions of glutathione, and peptides and amino acids related to glutathione synthesis and metabolism, on stress responses. In Glutathione: Biochemistry, Mechanisms of Action and Biotechnological Implications (pp. 35-53). Nova Science Publishers, Inc..