Central functions of L-arginine and its metabolites for stress behavior

Shozo Tomonaga, D. Michael Denbow, Mitsuhiro Furuse

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

L-Arginine is an essential amino acid for birds, carnivores and young mammals and a conditionally essential amino acid for adults. L-Arginine can be catabolized by four sets of enzymes in mammalian cells, resulting in the production of urea, L-ornithine, L-proline, L-glutamate, polyamines, nitric oxide, creatine, agmatine, etc.. Unlike mammals, birds lack carbamyl phosphate synthetase, one of the urea cycle enzymes necessary for the synthesis of L-citrulline from L-ornithine in the liver and kidney. Therefore, it is impossible to synthesize L-arginine in birds, and L-arginine is classified as an essential amino acid for birds. In this chapter, we introduce recent studies about central functions of L-arginine and its metabolites for stress behavior. In particular, the functions in avian species are focused upon. In neonatal chicks, centrally injected L-arginine induces sedative and hypnotic effects under social separation stress. Among L-arginine metabolites, L-ornithine, L-proline and L-glutamate would especially contribute to these effects.

Original languageEnglish
Title of host publicationArginine Amino Acid
PublisherNova Science Publishers, Inc.
Pages163-189
Number of pages27
ISBN (Print)9781617619816
Publication statusPublished - Feb 1 2011

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Metabolites
Arginine
Birds
Ornithine
Essential Amino Acids
Mammals
Hypnotics and Sedatives
Proline
Urea
Glutamic Acid
Agmatine
Carbamyl Phosphate
Citrulline
Creatine
Polyamines
Enzymes
Ligases
Liver
Nitric Oxide
Cells

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Tomonaga, S., Michael Denbow, D., & Furuse, M. (2011). Central functions of L-arginine and its metabolites for stress behavior. In Arginine Amino Acid (pp. 163-189). Nova Science Publishers, Inc..

Central functions of L-arginine and its metabolites for stress behavior. / Tomonaga, Shozo; Michael Denbow, D.; Furuse, Mitsuhiro.

Arginine Amino Acid. Nova Science Publishers, Inc., 2011. p. 163-189.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tomonaga, S, Michael Denbow, D & Furuse, M 2011, Central functions of L-arginine and its metabolites for stress behavior. in Arginine Amino Acid. Nova Science Publishers, Inc., pp. 163-189.
Tomonaga S, Michael Denbow D, Furuse M. Central functions of L-arginine and its metabolites for stress behavior. In Arginine Amino Acid. Nova Science Publishers, Inc. 2011. p. 163-189
Tomonaga, Shozo ; Michael Denbow, D. ; Furuse, Mitsuhiro. / Central functions of L-arginine and its metabolites for stress behavior. Arginine Amino Acid. Nova Science Publishers, Inc., 2011. pp. 163-189
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