Central L-arginine reduced stress responses are mediated by L-ornithine in neonatal chicks

R. Suenaga, H. Yamane, S. Tomonaga, M. Asechi, N. Adachi, Y. Tsuneyoshi, I. Kurauchi, H. Sato, D. M. Denbow, Mitsuhiro Furuse

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Recently, we observed that central administration of L-arginine attenuated stress responses in neonatal chicks, but the contribution of nitric oxide (NO) to this response was minimal. The sedative and hypnotic effects of L-arginine may be due to L-arginine itself and/or its metabolites, excluding NO. To clarify the mechanism, the effect of intracerebroventricular (i.c.v.) injection of L-arginine metabolites on behavior under social separation stress was investigated. The i.c.v. injection of agmatine, a guanidino metabolite of L-arginine, had no effect during a 10 min behavioral test. In contrast, the i.c.v. injection of L-ornithine clearly attenuated the stress response in a dose-dependent manner, and induced sleep-like behavior. The L-ornithine concentration in the telencephalon and diencephalon increased following the i.c.v. injection of L-arginine. In addition, several free amino acids including L-alanine, glycine, L-proline and L-glutamic acid concentrations increased in the telencephalon. In conclusion, it appears that L-ornithine, produced by arginase from L-arginine in the brain, plays an important role in the sedative and hypnotic effects of L-arginine observed during a stress response. In addition, several other amino acids having a sedative effect might partly participate in the sedative and hypnotic effects of L-arginine.

Original languageEnglish
Pages (from-to)107-113
Number of pages7
JournalAmino Acids
Volume35
Issue number1
DOIs
Publication statusPublished - Jun 1 2008

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Ornithine
Arginine
Hypnotics and Sedatives
Metabolites
Telencephalon
Injections
Nitric Oxide
alanylglycine
Agmatine
Amino Acids
Arginase
Diencephalon
Proline
Glutamic Acid
Brain
Sleep

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Suenaga, R., Yamane, H., Tomonaga, S., Asechi, M., Adachi, N., Tsuneyoshi, Y., ... Furuse, M. (2008). Central L-arginine reduced stress responses are mediated by L-ornithine in neonatal chicks. Amino Acids, 35(1), 107-113. https://doi.org/10.1007/s00726-007-0617-x

Central L-arginine reduced stress responses are mediated by L-ornithine in neonatal chicks. / Suenaga, R.; Yamane, H.; Tomonaga, S.; Asechi, M.; Adachi, N.; Tsuneyoshi, Y.; Kurauchi, I.; Sato, H.; Denbow, D. M.; Furuse, Mitsuhiro.

In: Amino Acids, Vol. 35, No. 1, 01.06.2008, p. 107-113.

Research output: Contribution to journalArticle

Suenaga, R, Yamane, H, Tomonaga, S, Asechi, M, Adachi, N, Tsuneyoshi, Y, Kurauchi, I, Sato, H, Denbow, DM & Furuse, M 2008, 'Central L-arginine reduced stress responses are mediated by L-ornithine in neonatal chicks', Amino Acids, vol. 35, no. 1, pp. 107-113. https://doi.org/10.1007/s00726-007-0617-x
Suenaga R, Yamane H, Tomonaga S, Asechi M, Adachi N, Tsuneyoshi Y et al. Central L-arginine reduced stress responses are mediated by L-ornithine in neonatal chicks. Amino Acids. 2008 Jun 1;35(1):107-113. https://doi.org/10.1007/s00726-007-0617-x
Suenaga, R. ; Yamane, H. ; Tomonaga, S. ; Asechi, M. ; Adachi, N. ; Tsuneyoshi, Y. ; Kurauchi, I. ; Sato, H. ; Denbow, D. M. ; Furuse, Mitsuhiro. / Central L-arginine reduced stress responses are mediated by L-ornithine in neonatal chicks. In: Amino Acids. 2008 ; Vol. 35, No. 1. pp. 107-113.
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