TY - JOUR
T1 - Central L-cysteine induces sleep, and D-cysteine induces sleep and abnormal behavior during acute stress in neonatal chicks
AU - Yamane, Haruka
AU - Asechi, Mari
AU - Tsuneyoshi, Yousuke
AU - Denbow, D. Michael
AU - Furuse, Mitsuhiro
PY - 2009/8/1
Y1 - 2009/8/1
N2 - L-Cysteine (L-Cys) is a non-essential and glycogenic amino acid. Previously, we reported that the intracerebroventricular (i.c.v.) injection of L-Cys induced sedative effects under isolation-induced stress in neonatal chicks. L-Cys has an optical isomer, D-Cys. The aim of this study was to clarify the effect of L-Cys and D-Cys during a stressful condition in chicks. The i.c.v. injection of L-Cys and D-Cys (0.84 Οmol) decreased both distress vocalization and spontaneous activity induced by isolation. However, the two cysteine isomers induced different behaviors. L-Cys increased sleep-like behavior while D-Cys caused abnormal behavior including syncope as well as sleep-like behavior. In conclusion, while both L-Cys and D-Cys caused a sedative effect when injected i.c.v, D-Cys caused abnormal behavior and may be detrimental to neonatal chicks.
AB - L-Cysteine (L-Cys) is a non-essential and glycogenic amino acid. Previously, we reported that the intracerebroventricular (i.c.v.) injection of L-Cys induced sedative effects under isolation-induced stress in neonatal chicks. L-Cys has an optical isomer, D-Cys. The aim of this study was to clarify the effect of L-Cys and D-Cys during a stressful condition in chicks. The i.c.v. injection of L-Cys and D-Cys (0.84 Οmol) decreased both distress vocalization and spontaneous activity induced by isolation. However, the two cysteine isomers induced different behaviors. L-Cys increased sleep-like behavior while D-Cys caused abnormal behavior including syncope as well as sleep-like behavior. In conclusion, while both L-Cys and D-Cys caused a sedative effect when injected i.c.v, D-Cys caused abnormal behavior and may be detrimental to neonatal chicks.
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U2 - 10.1111/j.1740-0929.2009.00647.x
DO - 10.1111/j.1740-0929.2009.00647.x
M3 - Article
C2 - 20163603
AN - SCOPUS:66149108481
VL - 80
SP - 428
EP - 432
JO - Animal Science Journal
JF - Animal Science Journal
SN - 1344-3941
IS - 4
ER -