Central L-cysteine induces sleep, and D-cysteine induces sleep and abnormal behavior during acute stress in neonatal chicks

Haruka Yamane, Mari Asechi, Yousuke Tsuneyoshi, D. Michael Denbow, Mitsuhiro Furuse

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

L-Cysteine (L-Cys) is a non-essential and glycogenic amino acid. Previously, we reported that the intracerebroventricular (i.c.v.) injection of L-Cys induced sedative effects under isolation-induced stress in neonatal chicks. L-Cys has an optical isomer, D-Cys. The aim of this study was to clarify the effect of L-Cys and D-Cys during a stressful condition in chicks. The i.c.v. injection of L-Cys and D-Cys (0.84 Οmol) decreased both distress vocalization and spontaneous activity induced by isolation. However, the two cysteine isomers induced different behaviors. L-Cys increased sleep-like behavior while D-Cys caused abnormal behavior including syncope as well as sleep-like behavior. In conclusion, while both L-Cys and D-Cys caused a sedative effect when injected i.c.v, D-Cys caused abnormal behavior and may be detrimental to neonatal chicks.

Original languageEnglish
Pages (from-to)428-432
Number of pages5
JournalAnimal Science Journal
Volume80
Issue number4
DOIs
Publication statusPublished - Aug 1 2009

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)

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