Central L-ornithine, but not polyamines, induces a hypnotic effect in neonatal chicks under acute stress

Isao Kurauchi, Kazutaka Shigemi, Yusuke Kabuki, Kousuke Hamasu, Haruka Yamane, Mami Aoki, Yoko Kawada, Koji Morishita, D. Michael Denbow, Mitsuhiro Furuse

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

To clarify whether L-ornithine and/or its metabolite involves sedative and hypnotic effects under social separation stress, the effects of intracerebroventricular (i.c.v.) injection of L-ornithine and polyamines (putrescine, spermidine and spermine) were compared in chicks. Birds were injected i.c.v. with 0.5 μmol of L-ornithine, putrescine, spermidine, spermine or saline (control). After injection, chicks were immediately separated from the flock and monitored for the number of distress vocalizations and various postures. L-Ornithine greatly attenuated the stress response and caused sedative and hypnotic effects. Among the polyamines, only putrescine attenuated distress vocalizations but did not induce sleep. In conclusion, the sedative and hypnotic effect of L-ornithine was mainly induced by L-ornithine itself, while the polyamines contributed to the sedative, but not hypnotic, effect under social separation stress.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalNutritional Neuroscience
Volume13
Issue number1
DOIs
Publication statusPublished - Feb 1 2010

Fingerprint

Ornithine
Polyamines
Hypnotics and Sedatives
Putrescine
Spermidine
Spermine
Injections
Posture
Birds
Sleep

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Central L-ornithine, but not polyamines, induces a hypnotic effect in neonatal chicks under acute stress. / Kurauchi, Isao; Shigemi, Kazutaka; Kabuki, Yusuke; Hamasu, Kousuke; Yamane, Haruka; Aoki, Mami; Kawada, Yoko; Morishita, Koji; Denbow, D. Michael; Furuse, Mitsuhiro.

In: Nutritional Neuroscience, Vol. 13, No. 1, 01.02.2010, p. 17-20.

Research output: Contribution to journalArticle

Kurauchi, I, Shigemi, K, Kabuki, Y, Hamasu, K, Yamane, H, Aoki, M, Kawada, Y, Morishita, K, Denbow, DM & Furuse, M 2010, 'Central L-ornithine, but not polyamines, induces a hypnotic effect in neonatal chicks under acute stress', Nutritional Neuroscience, vol. 13, no. 1, pp. 17-20. https://doi.org/10.1179/147683010X12611460763481
Kurauchi, Isao ; Shigemi, Kazutaka ; Kabuki, Yusuke ; Hamasu, Kousuke ; Yamane, Haruka ; Aoki, Mami ; Kawada, Yoko ; Morishita, Koji ; Denbow, D. Michael ; Furuse, Mitsuhiro. / Central L-ornithine, but not polyamines, induces a hypnotic effect in neonatal chicks under acute stress. In: Nutritional Neuroscience. 2010 ; Vol. 13, No. 1. pp. 17-20.
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