Central l-proline attenuates stress-induced dopamine and serotonin metabolism in the chick forebrain

Kousuke Hamasu, Kazutaka Shigemi, Yusuke Kabuki, Shozo Tomonaga, D. Michael Denbow, Mitsuhiro Furuse

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Using microdialysis, we investigated the effect of l-proline on monoamine release in the medio-rostral neostriatum/hyperstriatum ventrale (MNH) of freely moving and restricted chicks. A 30 min handling-stress resulted in a significant increase in extracellular homovallinic acid (HVA), a dopamine metabolite, and 5-hydroxyindoleacetic acid (5-HIAA), a serotonin metabolite, in the MNH. l-Proline, perfused through the microdialysis probe into the MNH during the stressed condition, significantly attenuated the average dialysate concentration of HVA produced by handling-stress. Handling-stress resulted in a significant increase in 5-HIAA levels in the control group, which were attenuated by profusion with l-proline. l-Proline did not significantly modify basal concentrations of HVA or 5-HIAA in the MNH during control conditions. These results show that perfusion of l-proline modified the turnover/metabolism of dopamine and serotonin in the MNH caused by handling-stress.

Original languageEnglish
Pages (from-to)78-81
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - Aug 21 2009


All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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