Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma

Kentaro Nakashima; Yuichi Kodama; Takuro Nishikawa; Miho Nishimura; Nobuhiro Ito; Reiji Fukano; Yuko Nomura; Tetsuya Ueba; Tooru Inoue; Koichi Oshima; Jun Okamura; Jiro Inagaki

doi:10.1111/ped.12812

Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma

Kentaro Nakashima, Yuichi Kodama, Takuro Nishikawa, Miho Nishimura, Nobuhiro Ito, Reiji Fukano, Yuko Nomura, Tetsuya Ueba, Tooru Inoue, Koichi Oshima, Jun Okamura, Jiro Inagaki

Comprehensive Maternity and Perinatal Care Center

Research output: Contribution to journal › Article › peer-review

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Abstract

Epstein–Barr virus associated lymphoproliferative disorder (EBV-LPD) occurs in patients with immunodeficiency, but it has not been well described in patients who have received chemotherapy for solid tumors. We describe a child with rhabdomyosarcoma who developed isolated central nervous system (CNS) EBV-LPD during combination chemotherapy with vincristine, actinomycin D and cyclophosphamide. The patient was treated with high-dose methotrexate (HD-MTX) for CNS EBV-LPD and then treated with rituximab in addition to HD-MTX because of the emergence of LPD in the liver. I.v. rituximab combined with HD-MTX might be effective therapy for CNS EBV-LPD.

Original language	English
Pages (from-to)	388-390
Number of pages	3
Journal	Pediatrics International
Volume	58
Issue number	5
DOIs	https://doi.org/10.1111/ped.12812
Publication status	Published - May 1 2016

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health

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10.1111/ped.12812

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title = "Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma",

abstract = "Epstein–Barr virus associated lymphoproliferative disorder (EBV-LPD) occurs in patients with immunodeficiency, but it has not been well described in patients who have received chemotherapy for solid tumors. We describe a child with rhabdomyosarcoma who developed isolated central nervous system (CNS) EBV-LPD during combination chemotherapy with vincristine, actinomycin D and cyclophosphamide. The patient was treated with high-dose methotrexate (HD-MTX) for CNS EBV-LPD and then treated with rituximab in addition to HD-MTX because of the emergence of LPD in the liver. I.v. rituximab combined with HD-MTX might be effective therapy for CNS EBV-LPD.",

author = "Kentaro Nakashima and Yuichi Kodama and Takuro Nishikawa and Miho Nishimura and Nobuhiro Ito and Reiji Fukano and Yuko Nomura and Tetsuya Ueba and Tooru Inoue and Koichi Oshima and Jun Okamura and Jiro Inagaki",

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doi = "10.1111/ped.12812",

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TY - JOUR

T1 - Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma

AU - Nakashima, Kentaro

AU - Kodama, Yuichi

AU - Nishikawa, Takuro

AU - Nishimura, Miho

AU - Ito, Nobuhiro

AU - Fukano, Reiji

AU - Nomura, Yuko

AU - Ueba, Tetsuya

AU - Inoue, Tooru

AU - Oshima, Koichi

AU - Okamura, Jun

AU - Inagaki, Jiro

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Epstein–Barr virus associated lymphoproliferative disorder (EBV-LPD) occurs in patients with immunodeficiency, but it has not been well described in patients who have received chemotherapy for solid tumors. We describe a child with rhabdomyosarcoma who developed isolated central nervous system (CNS) EBV-LPD during combination chemotherapy with vincristine, actinomycin D and cyclophosphamide. The patient was treated with high-dose methotrexate (HD-MTX) for CNS EBV-LPD and then treated with rituximab in addition to HD-MTX because of the emergence of LPD in the liver. I.v. rituximab combined with HD-MTX might be effective therapy for CNS EBV-LPD.

AB - Epstein–Barr virus associated lymphoproliferative disorder (EBV-LPD) occurs in patients with immunodeficiency, but it has not been well described in patients who have received chemotherapy for solid tumors. We describe a child with rhabdomyosarcoma who developed isolated central nervous system (CNS) EBV-LPD during combination chemotherapy with vincristine, actinomycin D and cyclophosphamide. The patient was treated with high-dose methotrexate (HD-MTX) for CNS EBV-LPD and then treated with rituximab in addition to HD-MTX because of the emergence of LPD in the liver. I.v. rituximab combined with HD-MTX might be effective therapy for CNS EBV-LPD.

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DO - 10.1111/ped.12812

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EP - 390

JO - Pediatrics International

JF - Pediatrics International

IS - 5

ER -

Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma

Abstract

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