Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma

kentaro nakashima, Yuichi Kodama, Takuro Nishikawa, Miho Nishimura, Nobuhiro Ito, Reiji Fukano, Yuko Nomura, Tetsuya Ueba, Tooru Inoue, Koichi Oshima, Jun Okamura, Jiro Inagaki

Research output: Contribution to journalArticle

Abstract

Epstein–Barr virus associated lymphoproliferative disorder (EBV-LPD) occurs in patients with immunodeficiency, but it has not been well described in patients who have received chemotherapy for solid tumors. We describe a child with rhabdomyosarcoma who developed isolated central nervous system (CNS) EBV-LPD during combination chemotherapy with vincristine, actinomycin D and cyclophosphamide. The patient was treated with high-dose methotrexate (HD-MTX) for CNS EBV-LPD and then treated with rituximab in addition to HD-MTX because of the emergence of LPD in the liver. I.v. rituximab combined with HD-MTX might be effective therapy for CNS EBV-LPD.

Original languageEnglish
Pages (from-to)388-390
Number of pages3
JournalPediatrics International
Volume58
Issue number5
DOIs
Publication statusPublished - May 1 2016

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Lymphoproliferative Disorders
Rhabdomyosarcoma
Human Herpesvirus 4
Central Nervous System
Methotrexate
Viruses
Dactinomycin
Vincristine
Combination Drug Therapy
Cyclophosphamide
Drug Therapy
Liver
Neoplasms
Rituximab
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

nakashima, K., Kodama, Y., Nishikawa, T., Nishimura, M., Ito, N., Fukano, R., ... Inagaki, J. (2016). Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma. Pediatrics International, 58(5), 388-390. https://doi.org/10.1111/ped.12812

Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma. / nakashima, kentaro; Kodama, Yuichi; Nishikawa, Takuro; Nishimura, Miho; Ito, Nobuhiro; Fukano, Reiji; Nomura, Yuko; Ueba, Tetsuya; Inoue, Tooru; Oshima, Koichi; Okamura, Jun; Inagaki, Jiro.

In: Pediatrics International, Vol. 58, No. 5, 01.05.2016, p. 388-390.

Research output: Contribution to journalArticle

nakashima, K, Kodama, Y, Nishikawa, T, Nishimura, M, Ito, N, Fukano, R, Nomura, Y, Ueba, T, Inoue, T, Oshima, K, Okamura, J & Inagaki, J 2016, 'Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma', Pediatrics International, vol. 58, no. 5, pp. 388-390. https://doi.org/10.1111/ped.12812
nakashima K, Kodama Y, Nishikawa T, Nishimura M, Ito N, Fukano R et al. Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma. Pediatrics International. 2016 May 1;58(5):388-390. https://doi.org/10.1111/ped.12812
nakashima, kentaro ; Kodama, Yuichi ; Nishikawa, Takuro ; Nishimura, Miho ; Ito, Nobuhiro ; Fukano, Reiji ; Nomura, Yuko ; Ueba, Tetsuya ; Inoue, Tooru ; Oshima, Koichi ; Okamura, Jun ; Inagaki, Jiro. / Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma. In: Pediatrics International. 2016 ; Vol. 58, No. 5. pp. 388-390.
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