TY - JOUR
T1 - Central nervous system T-cell lymphoproliferative disorder in a patient with chronic active Epstein-Barr virus infection
AU - Ohga, Shouichi
AU - Takada, Hidetoshi
AU - Honda, Keiko
AU - Inamura, Takanori
AU - Gondo, Kenjiro
AU - Ohshima, Kohichi
AU - Yamamoto, Masahiro
AU - Hara, Toshiro
PY - 1999/1/1
Y1 - 1999/1/1
N2 - Purpose: Central nervous system (CNS)-T cell lymphoproliferative disorder (T-LPD) developing during the course of chronic active Epstein-Barr virus (CAEBV) infection is reported. Patients and Methods: CAEBV was diagnosed in a 14-month-old boy with fever, cytopenia, hepatosplenomegaly and abnormal high titers of anti-Epstein-Barr virus (EBV) antibodies. At 8 years of age, he had a splenectomy because of progressive disease. Results: After 27 months of clinical remission, muscle weakness and paresthesia developed. Magnetic resonance imaging of his brain showed spotty T2 prolongation in left parietal, bilateral frontal, and temporal white matter with meningeal enhancement. Brain biopsy revealed the cerebral infiltration of CD3+, CD4+, CD8-, CD45RO+, CD56-, and EBV-encoded RNA 1+ cells. Conclusions: The CNS involvement of EBV-associated T-LPD is a rare but serious complication in CAEBV without known underlying immunodeficiency.
AB - Purpose: Central nervous system (CNS)-T cell lymphoproliferative disorder (T-LPD) developing during the course of chronic active Epstein-Barr virus (CAEBV) infection is reported. Patients and Methods: CAEBV was diagnosed in a 14-month-old boy with fever, cytopenia, hepatosplenomegaly and abnormal high titers of anti-Epstein-Barr virus (EBV) antibodies. At 8 years of age, he had a splenectomy because of progressive disease. Results: After 27 months of clinical remission, muscle weakness and paresthesia developed. Magnetic resonance imaging of his brain showed spotty T2 prolongation in left parietal, bilateral frontal, and temporal white matter with meningeal enhancement. Brain biopsy revealed the cerebral infiltration of CD3+, CD4+, CD8-, CD45RO+, CD56-, and EBV-encoded RNA 1+ cells. Conclusions: The CNS involvement of EBV-associated T-LPD is a rare but serious complication in CAEBV without known underlying immunodeficiency.
UR - http://www.scopus.com/inward/record.url?scp=0033036382&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033036382&partnerID=8YFLogxK
U2 - 10.1097/00043426-199901000-00009
DO - 10.1097/00043426-199901000-00009
M3 - Article
C2 - 10029811
AN - SCOPUS:0033036382
SN - 1077-4114
VL - 21
SP - 42
EP - 46
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
IS - 1
ER -