Central pipecolic acid increases food intake under ad libitum feeding conditions in the neonatal chick

Tomo Takagi, Tetsuya Tachibana, Ei Suke Saito, Shouzou Tomonaga, Shin Saito, Takashi Bungo, D. Michael Denbow, Mitsuhiro Furuse

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

It has been demonstrated that L-pipecolic acid (L-PA) is a major metabolic intermediate of L-lysine in the mammalian and chicken brain. A previous study showed that intracerebroventricular (i.c.v.) injection of L-PA suppressed feeding in neonatal chicks, and the actions were associated with γ-aminobutyric acid (GABA)-B receptor activation. It has been reported that endogenous L-PA in the brain fluctuated under different feeding conditions. In the present study, we investigated the effect of i.c.v. injection of L-PA on food intake in the neonatal chick under ad libitum feeding conditions. The food intake was increased by 0.5 or 1.0 mg L-PA under ad libitum feeding conditions contrary to previous studies using fasted birds. A hyperphagic effect of L-PA (0.5 mg) was attenuated by both GABA-A receptor antagonist (picrotoxin, 0.5 μg) and GABA-B receptor antagonist (CGP54626, 21.0 ng). These results indicate that a hyperphagic effect of L-PA is mediated by both GABA-A and GABA-B receptors and L-PA differentially affects food intake under different feeding conditions in the neonatal chick.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalNeuroscience Letters
Volume347
Issue number2
DOIs
Publication statusPublished - Aug 21 2003

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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