Abstract
It has been demonstrated that L-pipecolic acid (L-PA) is a major metabolic intermediate of L-lysine in the mammalian and chicken brain. A previous study showed that intracerebroventricular (i.c.v.) injection of L-PA suppressed feeding in neonatal chicks, and the actions were associated with γ-aminobutyric acid (GABA)-B receptor activation. It has been reported that endogenous L-PA in the brain fluctuated under different feeding conditions. In the present study, we investigated the effect of i.c.v. injection of L-PA on food intake in the neonatal chick under ad libitum feeding conditions. The food intake was increased by 0.5 or 1.0 mg L-PA under ad libitum feeding conditions contrary to previous studies using fasted birds. A hyperphagic effect of L-PA (0.5 mg) was attenuated by both GABA-A receptor antagonist (picrotoxin, 0.5 μg) and GABA-B receptor antagonist (CGP54626, 21.0 ng). These results indicate that a hyperphagic effect of L-PA is mediated by both GABA-A and GABA-B receptors and L-PA differentially affects food intake under different feeding conditions in the neonatal chick.
| Original language | English |
|---|---|
| Pages (from-to) | 93-96 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 347 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 21 2003 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
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Central pipecolic acid increases food intake under ad libitum feeding conditions in the neonatal chick. / Takagi, Tomo; Tachibana, Tetsuya; Saito, Ei Suke; Tomonaga, Shouzou; Saito, Shin; Bungo, Takashi; Denbow, D. Michael; Furuse, Mitsuhiro.
In: Neuroscience Letters, Vol. 347, No. 2, 21.08.2003, p. 93-96.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Central pipecolic acid increases food intake under ad libitum feeding conditions in the neonatal chick
AU - Takagi, Tomo
AU - Tachibana, Tetsuya
AU - Saito, Ei Suke
AU - Tomonaga, Shouzou
AU - Saito, Shin
AU - Bungo, Takashi
AU - Denbow, D. Michael
AU - Furuse, Mitsuhiro
PY - 2003/8/21
Y1 - 2003/8/21
N2 - It has been demonstrated that L-pipecolic acid (L-PA) is a major metabolic intermediate of L-lysine in the mammalian and chicken brain. A previous study showed that intracerebroventricular (i.c.v.) injection of L-PA suppressed feeding in neonatal chicks, and the actions were associated with γ-aminobutyric acid (GABA)-B receptor activation. It has been reported that endogenous L-PA in the brain fluctuated under different feeding conditions. In the present study, we investigated the effect of i.c.v. injection of L-PA on food intake in the neonatal chick under ad libitum feeding conditions. The food intake was increased by 0.5 or 1.0 mg L-PA under ad libitum feeding conditions contrary to previous studies using fasted birds. A hyperphagic effect of L-PA (0.5 mg) was attenuated by both GABA-A receptor antagonist (picrotoxin, 0.5 μg) and GABA-B receptor antagonist (CGP54626, 21.0 ng). These results indicate that a hyperphagic effect of L-PA is mediated by both GABA-A and GABA-B receptors and L-PA differentially affects food intake under different feeding conditions in the neonatal chick.
AB - It has been demonstrated that L-pipecolic acid (L-PA) is a major metabolic intermediate of L-lysine in the mammalian and chicken brain. A previous study showed that intracerebroventricular (i.c.v.) injection of L-PA suppressed feeding in neonatal chicks, and the actions were associated with γ-aminobutyric acid (GABA)-B receptor activation. It has been reported that endogenous L-PA in the brain fluctuated under different feeding conditions. In the present study, we investigated the effect of i.c.v. injection of L-PA on food intake in the neonatal chick under ad libitum feeding conditions. The food intake was increased by 0.5 or 1.0 mg L-PA under ad libitum feeding conditions contrary to previous studies using fasted birds. A hyperphagic effect of L-PA (0.5 mg) was attenuated by both GABA-A receptor antagonist (picrotoxin, 0.5 μg) and GABA-B receptor antagonist (CGP54626, 21.0 ng). These results indicate that a hyperphagic effect of L-PA is mediated by both GABA-A and GABA-B receptors and L-PA differentially affects food intake under different feeding conditions in the neonatal chick.
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UR - http://www.scopus.com/inward/citedby.url?scp=0038302345&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(03)00701-8
DO - 10.1016/S0304-3940(03)00701-8
M3 - Article
VL - 347
SP - 93
EP - 96
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -