Cerebral B-cell lymphoma following treatment for Tolosa-Hunt syndrome

T. Takao, S. Kaku, T. Tashima, Toru Iwaki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We herein report a unique case of cerebral lymphoma which occurred after lymphocytic neuritis of cranial nerves causing Tolosa-Hunt syndrome and demonstrate the histological difference between these two diseases. A 70- year-old woman developed a sensory disturbance in the first and third divisions of the left trigeminal nerve and a left ocular movement disturbance five years before death. Although she was clinically diagnosed to have a schwannoma in the left cavernous sinus, a histologic examination verified a diffuse infiltration of T lymphocytes in the left trigeminal ganglion. Corticosteroid therapy was effective. Thereafter she demonstrated a disturbance of consciousness and dysphasia four years after surgery. A T1- weighted magnetic resonance image (MRI) disclosed high intensity lesions in both the basal ganglia and corpus callosum. She also showed progressive spastic paralysis. At autopsy a diagnosis of primary intracranial B-cell lymphoma was made. Although there was no invasion of the lymphoma cells into the left trigeminal nerves, a mild inflammatory infiltration of T cells still remained.

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalClinical Neuropathology
Volume18
Issue number2
Publication statusPublished - Mar 1 1999

Fingerprint

Tolosa-Hunt Syndrome
Trigeminal Nerve
B-Cell Lymphoma
Lymphoma
T-Lymphocytes
Neuritis
Trigeminal Ganglion
Cavernous Sinus
Muscle Spasticity
Cranial Nerves
Corpus Callosum
Aphasia
Neurilemmoma
Eye Movements
Basal Ganglia
Consciousness
Paralysis
Autopsy
Adrenal Cortex Hormones
Magnetic Resonance Spectroscopy

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology

Cite this

Cerebral B-cell lymphoma following treatment for Tolosa-Hunt syndrome. / Takao, T.; Kaku, S.; Tashima, T.; Iwaki, Toru.

In: Clinical Neuropathology, Vol. 18, No. 2, 01.03.1999, p. 87-92.

Research output: Contribution to journalArticle

Takao, T. ; Kaku, S. ; Tashima, T. ; Iwaki, Toru. / Cerebral B-cell lymphoma following treatment for Tolosa-Hunt syndrome. In: Clinical Neuropathology. 1999 ; Vol. 18, No. 2. pp. 87-92.
@article{7c8bd0148649430ca91d2b565483ce13,
title = "Cerebral B-cell lymphoma following treatment for Tolosa-Hunt syndrome",
abstract = "We herein report a unique case of cerebral lymphoma which occurred after lymphocytic neuritis of cranial nerves causing Tolosa-Hunt syndrome and demonstrate the histological difference between these two diseases. A 70- year-old woman developed a sensory disturbance in the first and third divisions of the left trigeminal nerve and a left ocular movement disturbance five years before death. Although she was clinically diagnosed to have a schwannoma in the left cavernous sinus, a histologic examination verified a diffuse infiltration of T lymphocytes in the left trigeminal ganglion. Corticosteroid therapy was effective. Thereafter she demonstrated a disturbance of consciousness and dysphasia four years after surgery. A T1- weighted magnetic resonance image (MRI) disclosed high intensity lesions in both the basal ganglia and corpus callosum. She also showed progressive spastic paralysis. At autopsy a diagnosis of primary intracranial B-cell lymphoma was made. Although there was no invasion of the lymphoma cells into the left trigeminal nerves, a mild inflammatory infiltration of T cells still remained.",
author = "T. Takao and S. Kaku and T. Tashima and Toru Iwaki",
year = "1999",
month = "3",
day = "1",
language = "English",
volume = "18",
pages = "87--92",
journal = "Clinical Neuropathology",
issn = "0722-5091",
publisher = "Dustri-Verlag Dr. Karl Feistle",
number = "2",

}

TY - JOUR

T1 - Cerebral B-cell lymphoma following treatment for Tolosa-Hunt syndrome

AU - Takao, T.

AU - Kaku, S.

AU - Tashima, T.

AU - Iwaki, Toru

PY - 1999/3/1

Y1 - 1999/3/1

N2 - We herein report a unique case of cerebral lymphoma which occurred after lymphocytic neuritis of cranial nerves causing Tolosa-Hunt syndrome and demonstrate the histological difference between these two diseases. A 70- year-old woman developed a sensory disturbance in the first and third divisions of the left trigeminal nerve and a left ocular movement disturbance five years before death. Although she was clinically diagnosed to have a schwannoma in the left cavernous sinus, a histologic examination verified a diffuse infiltration of T lymphocytes in the left trigeminal ganglion. Corticosteroid therapy was effective. Thereafter she demonstrated a disturbance of consciousness and dysphasia four years after surgery. A T1- weighted magnetic resonance image (MRI) disclosed high intensity lesions in both the basal ganglia and corpus callosum. She also showed progressive spastic paralysis. At autopsy a diagnosis of primary intracranial B-cell lymphoma was made. Although there was no invasion of the lymphoma cells into the left trigeminal nerves, a mild inflammatory infiltration of T cells still remained.

AB - We herein report a unique case of cerebral lymphoma which occurred after lymphocytic neuritis of cranial nerves causing Tolosa-Hunt syndrome and demonstrate the histological difference between these two diseases. A 70- year-old woman developed a sensory disturbance in the first and third divisions of the left trigeminal nerve and a left ocular movement disturbance five years before death. Although she was clinically diagnosed to have a schwannoma in the left cavernous sinus, a histologic examination verified a diffuse infiltration of T lymphocytes in the left trigeminal ganglion. Corticosteroid therapy was effective. Thereafter she demonstrated a disturbance of consciousness and dysphasia four years after surgery. A T1- weighted magnetic resonance image (MRI) disclosed high intensity lesions in both the basal ganglia and corpus callosum. She also showed progressive spastic paralysis. At autopsy a diagnosis of primary intracranial B-cell lymphoma was made. Although there was no invasion of the lymphoma cells into the left trigeminal nerves, a mild inflammatory infiltration of T cells still remained.

UR - http://www.scopus.com/inward/record.url?scp=0032979588&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032979588&partnerID=8YFLogxK

M3 - Article

C2 - 10192704

AN - SCOPUS:0032979588

VL - 18

SP - 87

EP - 92

JO - Clinical Neuropathology

JF - Clinical Neuropathology

SN - 0722-5091

IS - 2

ER -