Abstract
Cerebral blood flow, cerebral oxygen metabolic rate and cerebral glucose metabolic rate were measured with positron emission tomography (PET) in four patients with progressive supranuclear palsy (PSP). Decreased blood flow and hypometabolism of oxygen and glucose were found in both subcortical and cortical regions, particularly in the striatum including the head of the caudate nucleus and the frontal cortex. The coupling between blood flow and metabolism was preserved even in the regions which showed decreased blood flow and hypometabolism. These findings indicated the hypofunction, as revealed by decreased blood flow and hypometabolism on PET, both in the striatum and the frontal cortex, and which may underlie the pathophysiological mechanism of motor and mental disturbance in PSP.
| Original language | English |
|---|---|
| Pages (from-to) | 111-118 |
| Number of pages | 8 |
| Journal | Annals of Nuclear Medicine |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Dec 1 1989 |
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All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
Cite this
Cerebral blood flow, oxygen and glucose metabolism with PET in progressive supranuclear palsy. / Otsuka, Makoto; Ichiya, Yuichi; Kuwabara, Yasuo; Miyake, Yoshinori; Tahara, Takashi; Masuda, Kouji; Hosokawa, Shinichi; Goto, Ikuo; Kato, Motohiro; Ichimiya, Atsushi; Suetsugu, Motohiro.
In: Annals of Nuclear Medicine, Vol. 3, No. 3, 01.12.1989, p. 111-118.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebral blood flow, oxygen and glucose metabolism with PET in progressive supranuclear palsy
AU - Otsuka, Makoto
AU - Ichiya, Yuichi
AU - Kuwabara, Yasuo
AU - Miyake, Yoshinori
AU - Tahara, Takashi
AU - Masuda, Kouji
AU - Hosokawa, Shinichi
AU - Goto, Ikuo
AU - Kato, Motohiro
AU - Ichimiya, Atsushi
AU - Suetsugu, Motohiro
PY - 1989/12/1
Y1 - 1989/12/1
N2 - Cerebral blood flow, cerebral oxygen metabolic rate and cerebral glucose metabolic rate were measured with positron emission tomography (PET) in four patients with progressive supranuclear palsy (PSP). Decreased blood flow and hypometabolism of oxygen and glucose were found in both subcortical and cortical regions, particularly in the striatum including the head of the caudate nucleus and the frontal cortex. The coupling between blood flow and metabolism was preserved even in the regions which showed decreased blood flow and hypometabolism. These findings indicated the hypofunction, as revealed by decreased blood flow and hypometabolism on PET, both in the striatum and the frontal cortex, and which may underlie the pathophysiological mechanism of motor and mental disturbance in PSP.
AB - Cerebral blood flow, cerebral oxygen metabolic rate and cerebral glucose metabolic rate were measured with positron emission tomography (PET) in four patients with progressive supranuclear palsy (PSP). Decreased blood flow and hypometabolism of oxygen and glucose were found in both subcortical and cortical regions, particularly in the striatum including the head of the caudate nucleus and the frontal cortex. The coupling between blood flow and metabolism was preserved even in the regions which showed decreased blood flow and hypometabolism. These findings indicated the hypofunction, as revealed by decreased blood flow and hypometabolism on PET, both in the striatum and the frontal cortex, and which may underlie the pathophysiological mechanism of motor and mental disturbance in PSP.
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U2 - 10.1007/BF03178296
DO - 10.1007/BF03178296
M3 - Article
VL - 3
SP - 111
EP - 118
JO - Annals of Nuclear Medicine
JF - Annals of Nuclear Medicine
SN - 0914-7187
IS - 3
ER -