Cerebral blood flow, oxygen and glucose metabolism with PET in progressive supranuclear palsy

Makoto Otsuka; Yuichi Ichiya; Yasuo Kuwabara; Yoshinori Miyake; Takashi Tahara; Kouji Masuda; Shinichi Hosokawa; Ikuo Goto; Motohiro Kato; Atsushi Ichimiya; Motohiro Suetsugu

doi:10.1007/BF03178296

Cerebral blood flow, oxygen and glucose metabolism with PET in progressive supranuclear palsy

Makoto Otsuka, Yuichi Ichiya, Yasuo Kuwabara, Yoshinori Miyake, Takashi Tahara, Kouji Masuda, Shinichi Hosokawa, Ikuo Goto, Motohiro Kato, Atsushi Ichimiya, Motohiro Suetsugu

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Abstract

Cerebral blood flow, cerebral oxygen metabolic rate and cerebral glucose metabolic rate were measured with positron emission tomography (PET) in four patients with progressive supranuclear palsy (PSP). Decreased blood flow and hypometabolism of oxygen and glucose were found in both subcortical and cortical regions, particularly in the striatum including the head of the caudate nucleus and the frontal cortex. The coupling between blood flow and metabolism was preserved even in the regions which showed decreased blood flow and hypometabolism. These findings indicated the hypofunction, as revealed by decreased blood flow and hypometabolism on PET, both in the striatum and the frontal cortex, and which may underlie the pathophysiological mechanism of motor and mental disturbance in PSP.

Original language	English
Pages (from-to)	111-118
Number of pages	8
Journal	Annals of Nuclear Medicine
Volume	3
Issue number	3
DOIs	https://doi.org/10.1007/BF03178296
Publication status	Published - Dec 1 1989

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging

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10.1007/BF03178296

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title = "Cerebral blood flow, oxygen and glucose metabolism with PET in progressive supranuclear palsy",

abstract = "Cerebral blood flow, cerebral oxygen metabolic rate and cerebral glucose metabolic rate were measured with positron emission tomography (PET) in four patients with progressive supranuclear palsy (PSP). Decreased blood flow and hypometabolism of oxygen and glucose were found in both subcortical and cortical regions, particularly in the striatum including the head of the caudate nucleus and the frontal cortex. The coupling between blood flow and metabolism was preserved even in the regions which showed decreased blood flow and hypometabolism. These findings indicated the hypofunction, as revealed by decreased blood flow and hypometabolism on PET, both in the striatum and the frontal cortex, and which may underlie the pathophysiological mechanism of motor and mental disturbance in PSP.",

author = "Makoto Otsuka and Yuichi Ichiya and Yasuo Kuwabara and Yoshinori Miyake and Takashi Tahara and Kouji Masuda and Shinichi Hosokawa and Ikuo Goto and Motohiro Kato and Atsushi Ichimiya and Motohiro Suetsugu",

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T1 - Cerebral blood flow, oxygen and glucose metabolism with PET in progressive supranuclear palsy

AU - Otsuka, Makoto

AU - Ichiya, Yuichi

AU - Kuwabara, Yasuo

AU - Miyake, Yoshinori

AU - Tahara, Takashi

AU - Masuda, Kouji

AU - Hosokawa, Shinichi

AU - Goto, Ikuo

AU - Kato, Motohiro

AU - Ichimiya, Atsushi

AU - Suetsugu, Motohiro

PY - 1989/12/1

Y1 - 1989/12/1

N2 - Cerebral blood flow, cerebral oxygen metabolic rate and cerebral glucose metabolic rate were measured with positron emission tomography (PET) in four patients with progressive supranuclear palsy (PSP). Decreased blood flow and hypometabolism of oxygen and glucose were found in both subcortical and cortical regions, particularly in the striatum including the head of the caudate nucleus and the frontal cortex. The coupling between blood flow and metabolism was preserved even in the regions which showed decreased blood flow and hypometabolism. These findings indicated the hypofunction, as revealed by decreased blood flow and hypometabolism on PET, both in the striatum and the frontal cortex, and which may underlie the pathophysiological mechanism of motor and mental disturbance in PSP.

AB - Cerebral blood flow, cerebral oxygen metabolic rate and cerebral glucose metabolic rate were measured with positron emission tomography (PET) in four patients with progressive supranuclear palsy (PSP). Decreased blood flow and hypometabolism of oxygen and glucose were found in both subcortical and cortical regions, particularly in the striatum including the head of the caudate nucleus and the frontal cortex. The coupling between blood flow and metabolism was preserved even in the regions which showed decreased blood flow and hypometabolism. These findings indicated the hypofunction, as revealed by decreased blood flow and hypometabolism on PET, both in the striatum and the frontal cortex, and which may underlie the pathophysiological mechanism of motor and mental disturbance in PSP.

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Cerebral blood flow, oxygen and glucose metabolism with PET in progressive supranuclear palsy

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