Cerebral Blood Flow Reduction Associated with Orientation for Time in Amnesic Mild Cognitive Impairment and Alzheimer Disease Patients

kenichiro yamashita, Yoshihide Taniwaki, Hidetsuna Utsunomiya, Takayuki Taniwaki

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Impairment of orientation for time (OT) is a characteristic symptom of Alzheimer disease (AD). However, the brain regions underlying OT remain to be elucidated. Using single photon emission computed tomography (SPECT), we examined the brain regions exhibiting hypoperfusion that were associated with OT. METHODS: We compared regional cerebral blood flow (rCBF) differences between AD and amnesic mild cognitive impairment (aMCI) or normal subjects using 3-dimensional stereotactic surface projection (3D-SSP) analysis. AD patients were divided into OT good and poor groups according to their mean OT scores, and rCBF then compared between the groups to elucidate OT-specific brain areas. RESULTS: 3D-SSP analysis showed reduced rCBF in the left superior parietal lobule (SPL) and bilateral inferior parietal lobule (IPL) in AD patients. In the poor OT group, 3D-SSP analysis revealed hypoperfusion in the bilateral SPL, IPL, posterior cingulated cortex (PCC), and precuneus. Among these areas, region of interest analysis revealed a significant higher number of hypoperfused pixels in the left PCC in the OT poor AD group. CONCLUSIONS: Our SPECT study suggested that hypoperfusion in the left SPL and bilateral IPL was AD specific, and reduced rCBF in the left PCC was specifically associated with OT.

Original languageEnglish
Pages (from-to)590-594
Number of pages5
JournalJournal of Neuroimaging
Volume24
Issue number6
DOIs
Publication statusPublished - Jan 1 2014
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Parietal Lobe
Alzheimer Disease
Regional Blood Flow
Single-Photon Emission-Computed Tomography
Brain
Cognitive Dysfunction

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Cerebral Blood Flow Reduction Associated with Orientation for Time in Amnesic Mild Cognitive Impairment and Alzheimer Disease Patients. / yamashita, kenichiro; Taniwaki, Yoshihide; Utsunomiya, Hidetsuna; Taniwaki, Takayuki.

In: Journal of Neuroimaging, Vol. 24, No. 6, 01.01.2014, p. 590-594.

Research output: Contribution to journalArticle

@article{56c1f593777c4df4b03ea672b67f1483,
title = "Cerebral Blood Flow Reduction Associated with Orientation for Time in Amnesic Mild Cognitive Impairment and Alzheimer Disease Patients",
abstract = "BACKGROUND AND PURPOSE: Impairment of orientation for time (OT) is a characteristic symptom of Alzheimer disease (AD). However, the brain regions underlying OT remain to be elucidated. Using single photon emission computed tomography (SPECT), we examined the brain regions exhibiting hypoperfusion that were associated with OT. METHODS: We compared regional cerebral blood flow (rCBF) differences between AD and amnesic mild cognitive impairment (aMCI) or normal subjects using 3-dimensional stereotactic surface projection (3D-SSP) analysis. AD patients were divided into OT good and poor groups according to their mean OT scores, and rCBF then compared between the groups to elucidate OT-specific brain areas. RESULTS: 3D-SSP analysis showed reduced rCBF in the left superior parietal lobule (SPL) and bilateral inferior parietal lobule (IPL) in AD patients. In the poor OT group, 3D-SSP analysis revealed hypoperfusion in the bilateral SPL, IPL, posterior cingulated cortex (PCC), and precuneus. Among these areas, region of interest analysis revealed a significant higher number of hypoperfused pixels in the left PCC in the OT poor AD group. CONCLUSIONS: Our SPECT study suggested that hypoperfusion in the left SPL and bilateral IPL was AD specific, and reduced rCBF in the left PCC was specifically associated with OT.",
author = "kenichiro yamashita and Yoshihide Taniwaki and Hidetsuna Utsunomiya and Takayuki Taniwaki",
year = "2014",
month = "1",
day = "1",
doi = "10.1111/jon.12096",
language = "English",
volume = "24",
pages = "590--594",
journal = "Journal of Neuroimaging",
issn = "1051-2284",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Cerebral Blood Flow Reduction Associated with Orientation for Time in Amnesic Mild Cognitive Impairment and Alzheimer Disease Patients

AU - yamashita, kenichiro

AU - Taniwaki, Yoshihide

AU - Utsunomiya, Hidetsuna

AU - Taniwaki, Takayuki

PY - 2014/1/1

Y1 - 2014/1/1

N2 - BACKGROUND AND PURPOSE: Impairment of orientation for time (OT) is a characteristic symptom of Alzheimer disease (AD). However, the brain regions underlying OT remain to be elucidated. Using single photon emission computed tomography (SPECT), we examined the brain regions exhibiting hypoperfusion that were associated with OT. METHODS: We compared regional cerebral blood flow (rCBF) differences between AD and amnesic mild cognitive impairment (aMCI) or normal subjects using 3-dimensional stereotactic surface projection (3D-SSP) analysis. AD patients were divided into OT good and poor groups according to their mean OT scores, and rCBF then compared between the groups to elucidate OT-specific brain areas. RESULTS: 3D-SSP analysis showed reduced rCBF in the left superior parietal lobule (SPL) and bilateral inferior parietal lobule (IPL) in AD patients. In the poor OT group, 3D-SSP analysis revealed hypoperfusion in the bilateral SPL, IPL, posterior cingulated cortex (PCC), and precuneus. Among these areas, region of interest analysis revealed a significant higher number of hypoperfused pixels in the left PCC in the OT poor AD group. CONCLUSIONS: Our SPECT study suggested that hypoperfusion in the left SPL and bilateral IPL was AD specific, and reduced rCBF in the left PCC was specifically associated with OT.

AB - BACKGROUND AND PURPOSE: Impairment of orientation for time (OT) is a characteristic symptom of Alzheimer disease (AD). However, the brain regions underlying OT remain to be elucidated. Using single photon emission computed tomography (SPECT), we examined the brain regions exhibiting hypoperfusion that were associated with OT. METHODS: We compared regional cerebral blood flow (rCBF) differences between AD and amnesic mild cognitive impairment (aMCI) or normal subjects using 3-dimensional stereotactic surface projection (3D-SSP) analysis. AD patients were divided into OT good and poor groups according to their mean OT scores, and rCBF then compared between the groups to elucidate OT-specific brain areas. RESULTS: 3D-SSP analysis showed reduced rCBF in the left superior parietal lobule (SPL) and bilateral inferior parietal lobule (IPL) in AD patients. In the poor OT group, 3D-SSP analysis revealed hypoperfusion in the bilateral SPL, IPL, posterior cingulated cortex (PCC), and precuneus. Among these areas, region of interest analysis revealed a significant higher number of hypoperfused pixels in the left PCC in the OT poor AD group. CONCLUSIONS: Our SPECT study suggested that hypoperfusion in the left SPL and bilateral IPL was AD specific, and reduced rCBF in the left PCC was specifically associated with OT.

UR - http://www.scopus.com/inward/record.url?scp=84938532196&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938532196&partnerID=8YFLogxK

U2 - 10.1111/jon.12096

DO - 10.1111/jon.12096

M3 - Article

C2 - 24593247

AN - SCOPUS:84938532196

VL - 24

SP - 590

EP - 594

JO - Journal of Neuroimaging

JF - Journal of Neuroimaging

SN - 1051-2284

IS - 6

ER -