Cerebral concentrations of myo-inositol in rats with induced brain death

Akiko Kiyoshima, Keiko Kudo, Yoshinobu Goto, Shozo Tobimatsu, Noriaki Ikeda

Research output: Contribution to journalArticlepeer-review


In anaesthetized, mechanically ventilated rats with brain death induced by epidural balloon inflation, we assessed the levels of cerebral myo-inositol in three brain areas 4 h after brain death had been confirmed. The levels were measured using HPLC, along with the water content. Myo-inositol levels were significantly increased in the cerebellum (P<0.05) and decreased in the brainstem (P<0.001), compared to findings in controls. Such changes can serve as hallmarks of brain death.

Original languageEnglish
Pages (from-to)110-112
Number of pages3
JournalLegal Medicine
Issue number2
Publication statusPublished - Mar 2005

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Issues, ethics and legal aspects


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