Cerebral concentrations of myo-inositol in rats with induced brain death

Akiko Kiyoshima; Keiko Kudo; Yoshinobu Goto; Shozo Tobimatsu; Noriaki Ikeda

doi:10.1016/j.legalmed.2004.08.006

Cerebral concentrations of myo-inositol in rats with induced brain death

Akiko Kiyoshima, Keiko Kudo, Yoshinobu Goto, Shozo Tobimatsu, Noriaki Ikeda

Research output: Contribution to journal › Article › peer-review

Abstract

In anaesthetized, mechanically ventilated rats with brain death induced by epidural balloon inflation, we assessed the levels of cerebral myo-inositol in three brain areas 4 h after brain death had been confirmed. The levels were measured using HPLC, along with the water content. Myo-inositol levels were significantly increased in the cerebellum (P<0.05) and decreased in the brainstem (P<0.001), compared to findings in controls. Such changes can serve as hallmarks of brain death.

Original language	English
Pages (from-to)	110-112
Number of pages	3
Journal	Legal Medicine
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/j.legalmed.2004.08.006
Publication status	Published - Mar 2005

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Issues, ethics and legal aspects

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title = "Cerebral concentrations of myo-inositol in rats with induced brain death",

abstract = "In anaesthetized, mechanically ventilated rats with brain death induced by epidural balloon inflation, we assessed the levels of cerebral myo-inositol in three brain areas 4 h after brain death had been confirmed. The levels were measured using HPLC, along with the water content. Myo-inositol levels were significantly increased in the cerebellum (P<0.05) and decreased in the brainstem (P<0.001), compared to findings in controls. Such changes can serve as hallmarks of brain death.",

author = "Akiko Kiyoshima and Keiko Kudo and Yoshinobu Goto and Shozo Tobimatsu and Noriaki Ikeda",

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AU - Ikeda, Noriaki

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