Cerebral concentrations of myo-inositol in rats with induced brain death

Akiko Kiyoshima; Keiko Kudo; Yoshinobu Goto; Shozo Tobimatsu; Noriaki Ikeda

doi:10.1016/j.legalmed.2004.08.006

Cerebral concentrations of myo-inositol in rats with induced brain death

Akiko Kiyoshima, Keiko Kudo, Yoshinobu Goto, Shozo Tobimatsu, Noriaki Ikeda

Research output: Contribution to journal › Article

Abstract

In anaesthetized, mechanically ventilated rats with brain death induced by epidural balloon inflation, we assessed the levels of cerebral myo-inositol in three brain areas 4 h after brain death had been confirmed. The levels were measured using HPLC, along with the water content. Myo-inositol levels were significantly increased in the cerebellum (P<0.05) and decreased in the brainstem (P<0.001), compared to findings in controls. Such changes can serve as hallmarks of brain death.

Original language	English
Pages (from-to)	110-112
Number of pages	3
Journal	Legal Medicine
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/j.legalmed.2004.08.006
Publication status	Published - Mar 2005

Fingerprint

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Issues, ethics and legal aspects

Cite this

Kiyoshima, A., Kudo, K., Goto, Y., Tobimatsu, S., & Ikeda, N. (2005). Cerebral concentrations of myo-inositol in rats with induced brain death. Legal Medicine, 7(2), 110-112. https://doi.org/10.1016/j.legalmed.2004.08.006

@article{2b647bffba2f4edcb940dd876dd50ba4,

title = "Cerebral concentrations of myo-inositol in rats with induced brain death",

abstract = "In anaesthetized, mechanically ventilated rats with brain death induced by epidural balloon inflation, we assessed the levels of cerebral myo-inositol in three brain areas 4 h after brain death had been confirmed. The levels were measured using HPLC, along with the water content. Myo-inositol levels were significantly increased in the cerebellum (P<0.05) and decreased in the brainstem (P<0.001), compared to findings in controls. Such changes can serve as hallmarks of brain death.",

author = "Akiko Kiyoshima and Keiko Kudo and Yoshinobu Goto and Shozo Tobimatsu and Noriaki Ikeda",

year = "2005",

month = "3",

doi = "10.1016/j.legalmed.2004.08.006",

language = "English",

volume = "7",

pages = "110--112",

journal = "Legal Medicine",

issn = "1344-6223",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Cerebral concentrations of myo-inositol in rats with induced brain death

AU - Kiyoshima, Akiko

AU - Kudo, Keiko

AU - Goto, Yoshinobu

AU - Tobimatsu, Shozo

AU - Ikeda, Noriaki

PY - 2005/3

Y1 - 2005/3

N2 - In anaesthetized, mechanically ventilated rats with brain death induced by epidural balloon inflation, we assessed the levels of cerebral myo-inositol in three brain areas 4 h after brain death had been confirmed. The levels were measured using HPLC, along with the water content. Myo-inositol levels were significantly increased in the cerebellum (P<0.05) and decreased in the brainstem (P<0.001), compared to findings in controls. Such changes can serve as hallmarks of brain death.

AB - In anaesthetized, mechanically ventilated rats with brain death induced by epidural balloon inflation, we assessed the levels of cerebral myo-inositol in three brain areas 4 h after brain death had been confirmed. The levels were measured using HPLC, along with the water content. Myo-inositol levels were significantly increased in the cerebellum (P<0.05) and decreased in the brainstem (P<0.001), compared to findings in controls. Such changes can serve as hallmarks of brain death.

UR - http://www.scopus.com/inward/record.url?scp=13644271332&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13644271332&partnerID=8YFLogxK

U2 - 10.1016/j.legalmed.2004.08.006

DO - 10.1016/j.legalmed.2004.08.006

M3 - Article

C2 - 15708334

AN - SCOPUS:13644271332

VL - 7

SP - 110

EP - 112

JO - Legal Medicine

JF - Legal Medicine

SN - 1344-6223

IS - 2

ER -

Access to Document

10.1016/j.legalmed.2004.08.006