Cerebral concentrations of myo-inositol in rats with induced brain death

Akiko Kiyoshima, Keiko Kudo, Yoshinobu Goto, Shozo Tobimatsu, Noriaki Ikeda

Research output: Contribution to journalArticle

Abstract

In anaesthetized, mechanically ventilated rats with brain death induced by epidural balloon inflation, we assessed the levels of cerebral myo-inositol in three brain areas 4 h after brain death had been confirmed. The levels were measured using HPLC, along with the water content. Myo-inositol levels were significantly increased in the cerebellum (P<0.05) and decreased in the brainstem (P<0.001), compared to findings in controls. Such changes can serve as hallmarks of brain death.

Original languageEnglish
Pages (from-to)110-112
Number of pages3
JournalLegal Medicine
Volume7
Issue number2
DOIs
Publication statusPublished - Jan 1 2005

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Brain Death
Inositol
Economic Inflation
Cerebellum
Brain Stem
High Pressure Liquid Chromatography
Water
Brain

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Issues, ethics and legal aspects

Cite this

Cerebral concentrations of myo-inositol in rats with induced brain death. / Kiyoshima, Akiko; Kudo, Keiko; Goto, Yoshinobu; Tobimatsu, Shozo; Ikeda, Noriaki.

In: Legal Medicine, Vol. 7, No. 2, 01.01.2005, p. 110-112.

Research output: Contribution to journalArticle

Kiyoshima, Akiko ; Kudo, Keiko ; Goto, Yoshinobu ; Tobimatsu, Shozo ; Ikeda, Noriaki. / Cerebral concentrations of myo-inositol in rats with induced brain death. In: Legal Medicine. 2005 ; Vol. 7, No. 2. pp. 110-112.
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