Abstract
In anaesthetized, mechanically ventilated rats with brain death induced by epidural balloon inflation, we assessed the levels of cerebral myo-inositol in three brain areas 4 h after brain death had been confirmed. The levels were measured using HPLC, along with the water content. Myo-inositol levels were significantly increased in the cerebellum (P<0.05) and decreased in the brainstem (P<0.001), compared to findings in controls. Such changes can serve as hallmarks of brain death.
| Original language | English |
|---|---|
| Pages (from-to) | 110-112 |
| Number of pages | 3 |
| Journal | Legal Medicine |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 1 2005 |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
- Issues, ethics and legal aspects
Cite this
Cerebral concentrations of myo-inositol in rats with induced brain death. / Kiyoshima, Akiko; Kudo, Keiko; Goto, Yoshinobu; Tobimatsu, Shozo; Ikeda, Noriaki.
In: Legal Medicine, Vol. 7, No. 2, 01.01.2005, p. 110-112.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebral concentrations of myo-inositol in rats with induced brain death
AU - Kiyoshima, Akiko
AU - Kudo, Keiko
AU - Goto, Yoshinobu
AU - Tobimatsu, Shozo
AU - Ikeda, Noriaki
PY - 2005/1/1
Y1 - 2005/1/1
N2 - In anaesthetized, mechanically ventilated rats with brain death induced by epidural balloon inflation, we assessed the levels of cerebral myo-inositol in three brain areas 4 h after brain death had been confirmed. The levels were measured using HPLC, along with the water content. Myo-inositol levels were significantly increased in the cerebellum (P<0.05) and decreased in the brainstem (P<0.001), compared to findings in controls. Such changes can serve as hallmarks of brain death.
AB - In anaesthetized, mechanically ventilated rats with brain death induced by epidural balloon inflation, we assessed the levels of cerebral myo-inositol in three brain areas 4 h after brain death had been confirmed. The levels were measured using HPLC, along with the water content. Myo-inositol levels were significantly increased in the cerebellum (P<0.05) and decreased in the brainstem (P<0.001), compared to findings in controls. Such changes can serve as hallmarks of brain death.
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UR - http://www.scopus.com/inward/citedby.url?scp=13644271332&partnerID=8YFLogxK
U2 - 10.1016/j.legalmed.2004.08.006
DO - 10.1016/j.legalmed.2004.08.006
M3 - Article
C2 - 15708334
AN - SCOPUS:13644271332
VL - 7
SP - 110
EP - 112
JO - Legal Medicine
JF - Legal Medicine
SN - 1344-6223
IS - 2
ER -