TY - JOUR
T1 - Cerebral concentrations of myo-inositol in rats with induced brain death
AU - Kiyoshima, Akiko
AU - Kudo, Keiko
AU - Goto, Yoshinobu
AU - Tobimatsu, Shozo
AU - Ikeda, Noriaki
N1 - Funding Information:
Part of this research was supported by grants from Casio Science Promotion Foundation. We thank K. Yamamoto for technical assistance with ECoG recording and M. Ohara (Fukuoka, Japan) for language assistance.
PY - 2005/3
Y1 - 2005/3
N2 - In anaesthetized, mechanically ventilated rats with brain death induced by epidural balloon inflation, we assessed the levels of cerebral myo-inositol in three brain areas 4 h after brain death had been confirmed. The levels were measured using HPLC, along with the water content. Myo-inositol levels were significantly increased in the cerebellum (P<0.05) and decreased in the brainstem (P<0.001), compared to findings in controls. Such changes can serve as hallmarks of brain death.
AB - In anaesthetized, mechanically ventilated rats with brain death induced by epidural balloon inflation, we assessed the levels of cerebral myo-inositol in three brain areas 4 h after brain death had been confirmed. The levels were measured using HPLC, along with the water content. Myo-inositol levels were significantly increased in the cerebellum (P<0.05) and decreased in the brainstem (P<0.001), compared to findings in controls. Such changes can serve as hallmarks of brain death.
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U2 - 10.1016/j.legalmed.2004.08.006
DO - 10.1016/j.legalmed.2004.08.006
M3 - Article
C2 - 15708334
AN - SCOPUS:13644271332
VL - 7
SP - 110
EP - 112
JO - Legal Medicine
JF - Legal Medicine
SN - 1344-6223
IS - 2
ER -