Abstract
We studied the cerebral blood flow (CBF), cerebrovascular response to hypercapnia, oxygen extraction fraction (OEF), metabolic rate for oxygen (CMRO2), blood volume (CBV) and transit time (TT: CBV/CBF) in Moyamoya disease using positron emission tomography (PET). The subjects consisted of 23 patients with Moyamoya disease, including eight pediatric and 15 adult patients. Among them, ten patients were examined both before and after surgery. The pediatric patients showed a marked increase in the CBV and a prolonged TT, especially in the striatum. The adult patients also showed a prolonged TT, but it was less prominent than that observed in pediatric patients, while the CBF remained at the level of the normal controls. The cerebrovascular response to hypercapnia was markedly impaired in both the pediatric and adult patients, which thus indicates a decrease in the hemodynamic reserve capacity. After surgery, the CBV, TT and cerebrovascular response to hypercapnia all improved, mainly in the temporal cortex where extracranial-intracranial (EC-IC) bypass surgery had been performed. In the striatum, the CBV also decreased, while the TT was shortened after surgery. A PET study was thus found to be useful for evaluating the cerebral hemodynamics in Moyamoya disease and monitoring the effect of surgery.
| Original language | English |
|---|---|
| Journal | Clinical Neurology and Neurosurgery |
| Volume | 99 |
| Issue number | SUPPL. 2 |
| Publication status | Published - Oct 1 1997 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Clinical Neurology
Cite this
Cerebral hemodynamics and metabolism in Moyamoya disease - A positron emission tomography study. / Kuwabara, Yasuo; Ichiya, Yuichi; Sasaki, Masayuki; Yoshida, Tsuyoshi; Masuda, Kouji; Ikezaki, Kiyonobu; Matsushima, Toshio; Fukui, Masashi.
In: Clinical Neurology and Neurosurgery, Vol. 99, No. SUPPL. 2, 01.10.1997.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebral hemodynamics and metabolism in Moyamoya disease - A positron emission tomography study
AU - Kuwabara, Yasuo
AU - Ichiya, Yuichi
AU - Sasaki, Masayuki
AU - Yoshida, Tsuyoshi
AU - Masuda, Kouji
AU - Ikezaki, Kiyonobu
AU - Matsushima, Toshio
AU - Fukui, Masashi
PY - 1997/10/1
Y1 - 1997/10/1
N2 - We studied the cerebral blood flow (CBF), cerebrovascular response to hypercapnia, oxygen extraction fraction (OEF), metabolic rate for oxygen (CMRO2), blood volume (CBV) and transit time (TT: CBV/CBF) in Moyamoya disease using positron emission tomography (PET). The subjects consisted of 23 patients with Moyamoya disease, including eight pediatric and 15 adult patients. Among them, ten patients were examined both before and after surgery. The pediatric patients showed a marked increase in the CBV and a prolonged TT, especially in the striatum. The adult patients also showed a prolonged TT, but it was less prominent than that observed in pediatric patients, while the CBF remained at the level of the normal controls. The cerebrovascular response to hypercapnia was markedly impaired in both the pediatric and adult patients, which thus indicates a decrease in the hemodynamic reserve capacity. After surgery, the CBV, TT and cerebrovascular response to hypercapnia all improved, mainly in the temporal cortex where extracranial-intracranial (EC-IC) bypass surgery had been performed. In the striatum, the CBV also decreased, while the TT was shortened after surgery. A PET study was thus found to be useful for evaluating the cerebral hemodynamics in Moyamoya disease and monitoring the effect of surgery.
AB - We studied the cerebral blood flow (CBF), cerebrovascular response to hypercapnia, oxygen extraction fraction (OEF), metabolic rate for oxygen (CMRO2), blood volume (CBV) and transit time (TT: CBV/CBF) in Moyamoya disease using positron emission tomography (PET). The subjects consisted of 23 patients with Moyamoya disease, including eight pediatric and 15 adult patients. Among them, ten patients were examined both before and after surgery. The pediatric patients showed a marked increase in the CBV and a prolonged TT, especially in the striatum. The adult patients also showed a prolonged TT, but it was less prominent than that observed in pediatric patients, while the CBF remained at the level of the normal controls. The cerebrovascular response to hypercapnia was markedly impaired in both the pediatric and adult patients, which thus indicates a decrease in the hemodynamic reserve capacity. After surgery, the CBV, TT and cerebrovascular response to hypercapnia all improved, mainly in the temporal cortex where extracranial-intracranial (EC-IC) bypass surgery had been performed. In the striatum, the CBV also decreased, while the TT was shortened after surgery. A PET study was thus found to be useful for evaluating the cerebral hemodynamics in Moyamoya disease and monitoring the effect of surgery.
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UR - http://www.scopus.com/inward/citedby.url?scp=0030716216&partnerID=8YFLogxK
M3 - Article
C2 - 9409411
AN - SCOPUS:0030716216
VL - 99
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
SN - 0303-8467
IS - SUPPL. 2
ER -