Cerebral metabolic changes in early multiple system atrophy: A PET study

Takayuki Taniwaki, Makoto Nakagawa, Takeshi Yamada, Tsuyoshi Yoshida, Yasumasa Ohyagi, Masayuki Sasaki, Yasuo Kuwabara, Shozo Tobimatsu, Jun-Ichi Kira

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Abstract

Previous positron emission tomography (PET) studies have shown widespread hypometabolism in the brain of advanced MSA but the time course of these metabolic abnormalities is largely unknown. In order to clarify the principal disease processes in multiple system atrophy (MSA) in the early stage, we investigated regional cerebral glucose metabolism (rCMGglc) and nigral dopaminergic function in nine patients with early stage of MSA using [18F]fluorodeoxyglucose (FDG) and 6-L-[18F]fluorodopa (18F-Dopa) positron emission tomography (PET) (two men and seven women; age, 59.3±5.4 years; disease duration, 29.7±14.6 months). The rCMRglc in the early MSA patients significantly decreased in the cerebellum, brainstem, and striatum compared with that in nine normal subjects. A significant correlation was found between the severity of autonomic dysfunction and rCMRglc within the brainstem. The severity of extrapyramidal signs also correlated with the decline of F-Dopa uptake but not that of rCMRglc within the striatum. The degree of atrophy on MRI has correlated with neither the clinical symptoms nor rCMRglc at the cerebellum and the brainstem. Our PET studies demonstrated widespread metabolic abnormalities except for the cerebral cortex in the brain of MSA even in the early stage. The hypometabolism in the brainstem was tightly linked to the autonomic dysfunction. Not the striatal dysfunction but the nigral damage may be responsible for the extrapyramidal symptoms in early MSA.

Original languageEnglish
Pages (from-to)79-84
Number of pages6
JournalJournal of the Neurological Sciences
Volume200
Issue number1-2
DOIs
Publication statusPublished - Aug 15 2002

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Multiple System Atrophy
Positron-Emission Tomography
Brain Stem
Substantia Nigra
Cerebellum
Corpus Striatum
Dihydroxyphenylalanine
Fluorodeoxyglucose F18
Brain
Cerebral Cortex
Atrophy
Glucose

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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Cerebral metabolic changes in early multiple system atrophy : A PET study. / Taniwaki, Takayuki; Nakagawa, Makoto; Yamada, Takeshi; Yoshida, Tsuyoshi; Ohyagi, Yasumasa; Sasaki, Masayuki; Kuwabara, Yasuo; Tobimatsu, Shozo; Kira, Jun-Ichi.

In: Journal of the Neurological Sciences, Vol. 200, No. 1-2, 15.08.2002, p. 79-84.

Research output: Contribution to journalArticle

Taniwaki, Takayuki ; Nakagawa, Makoto ; Yamada, Takeshi ; Yoshida, Tsuyoshi ; Ohyagi, Yasumasa ; Sasaki, Masayuki ; Kuwabara, Yasuo ; Tobimatsu, Shozo ; Kira, Jun-Ichi. / Cerebral metabolic changes in early multiple system atrophy : A PET study. In: Journal of the Neurological Sciences. 2002 ; Vol. 200, No. 1-2. pp. 79-84.
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