Cerebral Small-Vessel Disease in Neuro-Behçet Disease

Sohei Yoshimura, Tetsuro Ago, Masatoshi Koga, Masahiro Kamouchi, Takanari Kitazono

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Background Involvement of central nervous system is very common in Behçet disease, known as neuro-Behçet disease (NBD). However, there have been few reports which evaluated stroke-like cerebral small-vessel disease associated with Behçet disease. Objective We evaluated cerebral small-vessel lesions by using magnetic resonance imaging in 2 patients with NBD. Clinical Cases In a 41-year-old woman case, who developed dysarthria and left hemiparesis, diffusion-weighted images (DWI) showed small high-intensity areas in the bilateral internal capsule. The right lesion had a low apparent diffusion coefficient (ADC) value, whereas the left one had a high value. In a 59-year-old woman case, who developed dysarthria and left hemihypesthesia, DWI showed high-intensity areas in the right side of the pons and in the right peduncle of the midbrain. The lesion in the pons had a low ADC value, whereas the lesion in the midbrain had a high value. ADC map may be useful to identify symptomatic lesions in the brain, because only the lesions with low ADC values were symptomatic. Conclusions NBD should be considered in those who had not had any risk factors for ischemic stroke but experienced cerebral small-vessel disease.

Original languageEnglish
Pages (from-to)e237-e239
JournalJournal of Stroke and Cerebrovascular Diseases
Issue number8
Publication statusPublished - Aug 1 2015

All Science Journal Classification (ASJC) codes

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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