Cerebrospinal fluid concentrations of interleukin-1β, tumour necrosis factor-α, and interferon gamma in bacterial meningitis

Shoichi Ohga, T. Aoki, K. Okada, H. Akeda, K. Fujioka, A. Ohshima, T. Mori, I. Minamishima, K. Ueda

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

To investigate the role of the inflammatory cytokines, the cerebrospinal fluid concentrations of interleukin (IL)-1β, tumour necrosis factor-α (TNF-α), and interferon gamma (IFN-γ) were measured in 11 children with bacterial meningitis and two with mycoplasmic meningoencephalitis and compared with those in 50 children with aseptic meningitis and 15 with non-pleocytotic cerebrospinal fluid. Concentrations of IL-1β and TNF-α were each significantly higher in the cerebrospinal fluid of patients with bacterial meningitis than in those with aseptic meningitis or those with non-pleocytotic cerebrospinal fluid. IFN-γ was detected at low concentrations in the cerebrospinal fluid of only 2/11 of those with bacterial meningitis. On the other hand, the IFN-γ concentration was the highest in the cerebrospinal fluid of patients with aseptic meningitis. These results suggest that the inflammatory cytokines are differently released in the intrathecal space infected with viruses or bacteria.

Original languageEnglish
Pages (from-to)123-125
Number of pages3
JournalArchives of Disease in Childhood
Volume70
Issue number2
DOIs
Publication statusPublished - Jan 1 1994

Fingerprint

Bacterial Meningitides
Interleukin-1
Interferon-gamma
Cerebrospinal Fluid
Tumor Necrosis Factor-alpha
Aseptic Meningitis
Cytokines
Meningoencephalitis
Viruses
Bacteria

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Cerebrospinal fluid concentrations of interleukin-1β, tumour necrosis factor-α, and interferon gamma in bacterial meningitis. / Ohga, Shoichi; Aoki, T.; Okada, K.; Akeda, H.; Fujioka, K.; Ohshima, A.; Mori, T.; Minamishima, I.; Ueda, K.

In: Archives of Disease in Childhood, Vol. 70, No. 2, 01.01.1994, p. 123-125.

Research output: Contribution to journalArticle

Ohga, Shoichi ; Aoki, T. ; Okada, K. ; Akeda, H. ; Fujioka, K. ; Ohshima, A. ; Mori, T. ; Minamishima, I. ; Ueda, K. / Cerebrospinal fluid concentrations of interleukin-1β, tumour necrosis factor-α, and interferon gamma in bacterial meningitis. In: Archives of Disease in Childhood. 1994 ; Vol. 70, No. 2. pp. 123-125.
@article{1ed6e45208b94c288801199ef4ea5c12,
title = "Cerebrospinal fluid concentrations of interleukin-1β, tumour necrosis factor-α, and interferon gamma in bacterial meningitis",
abstract = "To investigate the role of the inflammatory cytokines, the cerebrospinal fluid concentrations of interleukin (IL)-1β, tumour necrosis factor-α (TNF-α), and interferon gamma (IFN-γ) were measured in 11 children with bacterial meningitis and two with mycoplasmic meningoencephalitis and compared with those in 50 children with aseptic meningitis and 15 with non-pleocytotic cerebrospinal fluid. Concentrations of IL-1β and TNF-α were each significantly higher in the cerebrospinal fluid of patients with bacterial meningitis than in those with aseptic meningitis or those with non-pleocytotic cerebrospinal fluid. IFN-γ was detected at low concentrations in the cerebrospinal fluid of only 2/11 of those with bacterial meningitis. On the other hand, the IFN-γ concentration was the highest in the cerebrospinal fluid of patients with aseptic meningitis. These results suggest that the inflammatory cytokines are differently released in the intrathecal space infected with viruses or bacteria.",
author = "Shoichi Ohga and T. Aoki and K. Okada and H. Akeda and K. Fujioka and A. Ohshima and T. Mori and I. Minamishima and K. Ueda",
year = "1994",
month = "1",
day = "1",
doi = "10.1136/adc.70.2.123",
language = "English",
volume = "70",
pages = "123--125",
journal = "Archives of Disease in Childhood",
issn = "0003-9888",
publisher = "BMJ Publishing Group",
number = "2",

}

TY - JOUR

T1 - Cerebrospinal fluid concentrations of interleukin-1β, tumour necrosis factor-α, and interferon gamma in bacterial meningitis

AU - Ohga, Shoichi

AU - Aoki, T.

AU - Okada, K.

AU - Akeda, H.

AU - Fujioka, K.

AU - Ohshima, A.

AU - Mori, T.

AU - Minamishima, I.

AU - Ueda, K.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - To investigate the role of the inflammatory cytokines, the cerebrospinal fluid concentrations of interleukin (IL)-1β, tumour necrosis factor-α (TNF-α), and interferon gamma (IFN-γ) were measured in 11 children with bacterial meningitis and two with mycoplasmic meningoencephalitis and compared with those in 50 children with aseptic meningitis and 15 with non-pleocytotic cerebrospinal fluid. Concentrations of IL-1β and TNF-α were each significantly higher in the cerebrospinal fluid of patients with bacterial meningitis than in those with aseptic meningitis or those with non-pleocytotic cerebrospinal fluid. IFN-γ was detected at low concentrations in the cerebrospinal fluid of only 2/11 of those with bacterial meningitis. On the other hand, the IFN-γ concentration was the highest in the cerebrospinal fluid of patients with aseptic meningitis. These results suggest that the inflammatory cytokines are differently released in the intrathecal space infected with viruses or bacteria.

AB - To investigate the role of the inflammatory cytokines, the cerebrospinal fluid concentrations of interleukin (IL)-1β, tumour necrosis factor-α (TNF-α), and interferon gamma (IFN-γ) were measured in 11 children with bacterial meningitis and two with mycoplasmic meningoencephalitis and compared with those in 50 children with aseptic meningitis and 15 with non-pleocytotic cerebrospinal fluid. Concentrations of IL-1β and TNF-α were each significantly higher in the cerebrospinal fluid of patients with bacterial meningitis than in those with aseptic meningitis or those with non-pleocytotic cerebrospinal fluid. IFN-γ was detected at low concentrations in the cerebrospinal fluid of only 2/11 of those with bacterial meningitis. On the other hand, the IFN-γ concentration was the highest in the cerebrospinal fluid of patients with aseptic meningitis. These results suggest that the inflammatory cytokines are differently released in the intrathecal space infected with viruses or bacteria.

UR - http://www.scopus.com/inward/record.url?scp=0028330539&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028330539&partnerID=8YFLogxK

U2 - 10.1136/adc.70.2.123

DO - 10.1136/adc.70.2.123

M3 - Article

C2 - 8129433

AN - SCOPUS:0028330539

VL - 70

SP - 123

EP - 125

JO - Archives of Disease in Childhood

JF - Archives of Disease in Childhood

SN - 0003-9888

IS - 2

ER -