Cerebrovascular responsiveness to hypercapnia in alzheimer's dementia and vascular dementia of the binswanger type

Yasuo Kuwabara, Yuichi Ichiya, Makoto Otsuka, Kouji Masuda, Atsushi Ichimiya, Masatoshi Fujishima

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Background and Purpose: Alzheimer's dementia is thought to be a primary degenerative dementia, whereas vascular dementia of the Binswanger type is an entity of vascular dementia. We evaluated the cerebrovascular responsiveness to hypercapnia to clarify the differences in the cerebral hemodynamics between two groups of patients. The subjects were eight younger control subjects, five age-matched control subjects, five Alzheimer's patients, and five patients with vascular dementia of the Binswanger type. Summary of Report: In the resting state, the regional cerebral blood flow was low in both Alzheimer's dementia and vascular dementia of the Binswanger type. The responsiveness to hypercapnia was preserved in Alzheimer's dementia, whereas it was impaired in vascular dementia of the Binswanger type in the cerebral cortices and in the deep white matter. Conclusions: These results suggest that small vascular lesions exist in vascular dementia of the Binswanger type but not in Alzheimer's dementia, even though regional cerebral blood flow was thought to decrease by hypometabolism in both types of dementia.

Original languageEnglish
Pages (from-to)594-598
Number of pages5
JournalStroke
Volume23
Issue number4
DOIs
Publication statusPublished - Apr 1992

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Vascular Dementia
Hypercapnia
Alzheimer Disease
Cerebrovascular Circulation
Regional Blood Flow
Dementia
Cerebral Cortex
Blood Vessels
Hemodynamics

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

Cite this

Kuwabara, Y., Ichiya, Y., Otsuka, M., Masuda, K., Ichimiya, A., & Fujishima, M. (1992). Cerebrovascular responsiveness to hypercapnia in alzheimer's dementia and vascular dementia of the binswanger type. Stroke, 23(4), 594-598. https://doi.org/10.1161/01.STR.23.4.594

Cerebrovascular responsiveness to hypercapnia in alzheimer's dementia and vascular dementia of the binswanger type. / Kuwabara, Yasuo; Ichiya, Yuichi; Otsuka, Makoto; Masuda, Kouji; Ichimiya, Atsushi; Fujishima, Masatoshi.

In: Stroke, Vol. 23, No. 4, 04.1992, p. 594-598.

Research output: Contribution to journalArticle

Kuwabara, Y, Ichiya, Y, Otsuka, M, Masuda, K, Ichimiya, A & Fujishima, M 1992, 'Cerebrovascular responsiveness to hypercapnia in alzheimer's dementia and vascular dementia of the binswanger type', Stroke, vol. 23, no. 4, pp. 594-598. https://doi.org/10.1161/01.STR.23.4.594
Kuwabara, Yasuo ; Ichiya, Yuichi ; Otsuka, Makoto ; Masuda, Kouji ; Ichimiya, Atsushi ; Fujishima, Masatoshi. / Cerebrovascular responsiveness to hypercapnia in alzheimer's dementia and vascular dementia of the binswanger type. In: Stroke. 1992 ; Vol. 23, No. 4. pp. 594-598.
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