Ceruletide inhibits phencyclidine-induced dopamine and serotonin release in rat prefrontal cortex

Kazuko Etou, Toshihide Kuroki, Takeshi Kawahara, Yuji Yonezawa, Nobutada Tashiro, Hideyuki Uchimura

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Phencyclidine (PCP; 5.0 mg/kg, IP) produced a greater increase in extracellular dopamine (DA) levels in the prefrontal cortex than in the striatum, while PCP increased the extracellular 5-hydroxytryptamine (serotonin; 5-HT) levels in the prefrontal cortex but not the striatum, as determined by in vivo microdialysis in awake, freely moving rats. The cholecystokinin (CCK)-related decapeptide ceruletide (120 and 400 μg/kg, IP), administered 60 min prior to PCP, significantly attenuated the PCP-induced increase in the extracellular levels of DA and 5-HT in the prefrontal cortex, but not in the striatum. These effects were reversed by PD 135,158, a selective CCK-B receptor antagonist (0.1 mg/kg, SC), administered 5 min prior to ceruletide. When administered alone, ceruletide (400 μg/kg, IP) significantly increased basal extracellular DA levels only in the prefrontal cortex. The selective N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine (0.5 mg/kg, IP) also increased extracellular DA levels in the prefrontal cortex, but this effect was unaffected by ceruletide pretreatment. These results suggest that ceruletide may differentially modulate basal and PCP-induced release of DA and 5-HT in the prefrontal cortex. Copyright (C) 1998 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)427-434
Number of pages8
JournalPharmacology Biochemistry and Behavior
Volume61
Issue number4
DOIs
Publication statusPublished - Dec 1998

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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