Change in overhauser effect-enhanced MRI signal in response to uPA highly expressing in tumor

Takuro Niidome, Nobukatsu Chijiiwa, Toshihide Yamasaki, Ken-Ichi Yamada, Takeshi Mori, Tatsuya Naganuma, Hideo Utsumi, Kazuhiro Ichikawa, Yoshiki Katayama

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Dendritic poly(L-lysine) polymers were modified with stable nitroxyl radicals through the substrate peptides of a protease specifically expressed in tumors. Cleavage of the peptides by the protease affected the Overhauser-enhanced MRI (OMRI) signal from the radicals. This system could be the basis of a functional tumor-imaging technique by OMRI.

Original languageEnglish
Pages (from-to)999-1001
Number of pages3
JournalChemistry Letters
Volume43
Issue number7
DOIs
Publication statusPublished - Jan 1 2014

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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