Change of oral to topical corticosteroid therapy exacerbated glucose tolerance in a patient with plaque psoriasis

Yui Hongo, Kenji Ashida, Kenji Ohe, Munechika Enjoji, Miyuki Yamaguchi, Tsuyoshi Kurata, Akiko Emoto, Hiroko Yamanouchi, Satoko Takagi, Hitoe Mori, Nozomi Kawata, Yoshio Hisata, Yuta Sakanishi, Kenichi Izumi, Takashi Sugioka, Keizo Anzai

Research output: Contribution to journalArticle

Abstract

Objective: Rare disease Background: Psoriasis is known as the most frequent disease treated by long-term topical steroids. It is also known that patients with thick, chronic plaques require the highest potency topical steroids. However, the treatment is limited to up to four weeks due to risk of systemic absorption. Case Report: An 80-year-old man was diagnosed with type 2 diabetes 16 years before, and was being administered insulin combined with alpha glucosidase inhibitor. He was diagnosed with plaque psoriasis and his oral steroid treatment was switched to topical steroid treatment due to lack of improvement and poorly controlled blood glucose level. The hypoglycemic events improved after the psoriatic lesions improved. Conclusions: Control of blood glucose level is difficult at the very beginning of topical steroid treatment for psoriasis especially if a patient is receiving insulin treatment. Intense monitoring of blood glucose level during initiation of topical steroid treatment is necessary to prevent unfavorable complications.

Original languageEnglish
Pages (from-to)1198-1203
Number of pages6
JournalAmerican Journal of Case Reports
Volume18
DOIs
Publication statusPublished - Nov 13 2017

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Psoriasis
Adrenal Cortex Hormones
Steroids
Glucose
Blood Glucose
Therapeutics
Insulin
Rare Diseases
Hypoglycemic Agents
Type 2 Diabetes Mellitus

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Change of oral to topical corticosteroid therapy exacerbated glucose tolerance in a patient with plaque psoriasis. / Hongo, Yui; Ashida, Kenji; Ohe, Kenji; Enjoji, Munechika; Yamaguchi, Miyuki; Kurata, Tsuyoshi; Emoto, Akiko; Yamanouchi, Hiroko; Takagi, Satoko; Mori, Hitoe; Kawata, Nozomi; Hisata, Yoshio; Sakanishi, Yuta; Izumi, Kenichi; Sugioka, Takashi; Anzai, Keizo.

In: American Journal of Case Reports, Vol. 18, 13.11.2017, p. 1198-1203.

Research output: Contribution to journalArticle

Hongo, Y, Ashida, K, Ohe, K, Enjoji, M, Yamaguchi, M, Kurata, T, Emoto, A, Yamanouchi, H, Takagi, S, Mori, H, Kawata, N, Hisata, Y, Sakanishi, Y, Izumi, K, Sugioka, T & Anzai, K 2017, 'Change of oral to topical corticosteroid therapy exacerbated glucose tolerance in a patient with plaque psoriasis', American Journal of Case Reports, vol. 18, pp. 1198-1203. https://doi.org/10.12659/AJCR.905470
Hongo, Yui ; Ashida, Kenji ; Ohe, Kenji ; Enjoji, Munechika ; Yamaguchi, Miyuki ; Kurata, Tsuyoshi ; Emoto, Akiko ; Yamanouchi, Hiroko ; Takagi, Satoko ; Mori, Hitoe ; Kawata, Nozomi ; Hisata, Yoshio ; Sakanishi, Yuta ; Izumi, Kenichi ; Sugioka, Takashi ; Anzai, Keizo. / Change of oral to topical corticosteroid therapy exacerbated glucose tolerance in a patient with plaque psoriasis. In: American Journal of Case Reports. 2017 ; Vol. 18. pp. 1198-1203.
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AU - Kurata, Tsuyoshi

AU - Emoto, Akiko

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AU - Kawata, Nozomi

AU - Hisata, Yoshio

AU - Sakanishi, Yuta

AU - Izumi, Kenichi

AU - Sugioka, Takashi

AU - Anzai, Keizo

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AB - Objective: Rare disease Background: Psoriasis is known as the most frequent disease treated by long-term topical steroids. It is also known that patients with thick, chronic plaques require the highest potency topical steroids. However, the treatment is limited to up to four weeks due to risk of systemic absorption. Case Report: An 80-year-old man was diagnosed with type 2 diabetes 16 years before, and was being administered insulin combined with alpha glucosidase inhibitor. He was diagnosed with plaque psoriasis and his oral steroid treatment was switched to topical steroid treatment due to lack of improvement and poorly controlled blood glucose level. The hypoglycemic events improved after the psoriatic lesions improved. Conclusions: Control of blood glucose level is difficult at the very beginning of topical steroid treatment for psoriasis especially if a patient is receiving insulin treatment. Intense monitoring of blood glucose level during initiation of topical steroid treatment is necessary to prevent unfavorable complications.

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