Changes in Aortic Distension Waveforms in Acute Hypoxemia and Acidosis: Fetal Lamb Study

Shoji Satoh, Yasuyuki Fujita, Yasuo Yumoto, Naoko Kinukawa, Hitoo Nakano

Research output: Contribution to journalArticlepeer-review

Abstract

The objective was to investigate the relationship between fetal aortic distension waveforms and fetal hypoxemia and/or acidosis. Aortic distension waveforms were recorded using an echo-tracking system in nine late-gestation catheterized fetal lambs. Under hypoxic conditions induced by inhalation of gas mixture, fetal blood pressure and aortic distension waveforms were recorded. Four parameters, namely peak systolic and end diastolic diameter, amplitude (ΔD) and ratio of ΔD to end diastolic diameter (%ΔD), were obtained, and correlations between these parameters and partial arterial oxygen tension (PaO2) and pH of fetal blood gas were analyzed. These four parameters were compared between the control, hypoxemic and asphyxic groups. The ΔD and %ΔD were significantly correlated with PaO2 and pH using linear regression analysis. Both the ΔD and %ΔD decreased significantly, in a stepwise fashion, in the hypoxemic and asphyxiated groups compared with controls using repeated measured analysis of variance. It was concluded that fetal aortic distension waveforms proved to be a useful tool to detect the deterioration in the fetal circulation secondary to intrauterine hypoxemia/asphyxia. (E-mail: satohs@oitakenbyo.jp).

Original languageEnglish
Pages (from-to)708-713
Number of pages6
JournalUltrasound in Medicine and Biology
Volume33
Issue number5
DOIs
Publication statusPublished - May 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

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