Changes in estrogen receptors α and β expression in the brain of mice exposed prenatally to bisphenol A

Keisuke Kawai, Shuji Murakami, Emiko Senba, Takeharu Yamanaka, Yuya Fujiwara, Chikako Arimura, Takehiro Nozaki, Masato Takii, Chiharu Kubo

Research output: Contribution to journalArticle

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Abstract

The expression of ERs α and β and serotonergic neurons were evaluated in the brains of mice prenatally exposed to Bisphenol A, a known endocrine disrupting chemical (EDc). Bisphenol A was administered orally at a dose of 2 ng/g body weight on gestinational days 11-17 to pregnant ICR mice. Newborn male offspring (Bis-A mice) were evaluated for the immunoreactivity of ERs α and β, serotonin, and serotonin transporter positive cells in the dorsal raphe nucleus (DRN). The serum testosterone level was also evaluated. In the Bis-A mice, the expression of ERs α and β at 5 and 13 weeks was increased compared with the controls (P < 0.04), but this difference disappeared by the 9th week. The serotonin, serotonin transporter, and testosterone level differences between two groups did not reach significance. Exposure to bisphenol A may have changed the expression of ERs in the brain, but did not directly affect serotonin neurons in the DRN.

Original languageEnglish
Pages (from-to)166-170
Number of pages5
JournalRegulatory Toxicology and Pharmacology
Volume47
Issue number2
DOIs
Publication statusPublished - Mar 1 2007

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Estrogen Receptors
Brain
Serotonin
Serotonin Plasma Membrane Transport Proteins
Neurons
Testosterone
Serotonergic Neurons
Endocrine Disruptors
Inbred ICR Mouse
Cells
Body Weight
Serum
bisphenol A
Dorsal Raphe Nucleus

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Changes in estrogen receptors α and β expression in the brain of mice exposed prenatally to bisphenol A. / Kawai, Keisuke; Murakami, Shuji; Senba, Emiko; Yamanaka, Takeharu; Fujiwara, Yuya; Arimura, Chikako; Nozaki, Takehiro; Takii, Masato; Kubo, Chiharu.

In: Regulatory Toxicology and Pharmacology, Vol. 47, No. 2, 01.03.2007, p. 166-170.

Research output: Contribution to journalArticle

Kawai, K, Murakami, S, Senba, E, Yamanaka, T, Fujiwara, Y, Arimura, C, Nozaki, T, Takii, M & Kubo, C 2007, 'Changes in estrogen receptors α and β expression in the brain of mice exposed prenatally to bisphenol A', Regulatory Toxicology and Pharmacology, vol. 47, no. 2, pp. 166-170. https://doi.org/10.1016/j.yrtph.2006.04.002
Kawai, Keisuke ; Murakami, Shuji ; Senba, Emiko ; Yamanaka, Takeharu ; Fujiwara, Yuya ; Arimura, Chikako ; Nozaki, Takehiro ; Takii, Masato ; Kubo, Chiharu. / Changes in estrogen receptors α and β expression in the brain of mice exposed prenatally to bisphenol A. In: Regulatory Toxicology and Pharmacology. 2007 ; Vol. 47, No. 2. pp. 166-170.
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