Changes in interleukin-1 beta induced by rTMS are significantly correlated with partial improvement of cognitive dysfunction in treatment-resistant depression: a pilot study

Hiroshi Tateishi; Yoshito Mizoguchi; Atsushi Kawaguchi; Yoshiomi Imamura; Jun Matsushima; Hiroko Kunitake; Toru Murakawa; Yoshinori Haraguchi; Yutaka Kunitake; Toshihiko Maekawa; Takahiro A. Kato; Toyoko Asami; Akira Monji

doi:10.1016/j.psychres.2020.112995

Changes in interleukin-1 beta induced by rTMS are significantly correlated with partial improvement of cognitive dysfunction in treatment-resistant depression: a pilot study

Hiroshi Tateishi, Yoshito Mizoguchi, Atsushi Kawaguchi, Yoshiomi Imamura, Jun Matsushima, Hiroko Kunitake, Toru Murakawa, Yoshinori Haraguchi, Yutaka Kunitake, Toshihiko Maekawa, Takahiro A. Kato, Toyoko Asami, Akira Monji

Neuro-Psychiatry

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The impairment experienced by many individuals with depression is closely related to the cognitive symptoms of the disorder. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation method that provides a promising technique for improving cognitive symptoms in treatment-resistant depression (TRD). It has recently been demonstrated that TRD is associated with increased inflammatory process. In the present study, we investigated whether a relationship exists between changes in cognitive function and those in inflammatory cytokines before and after rTMS treatment. Eleven patients with TRD were enrolled in a high-frequency (10 Hz) rTMS study. Cognitive function, depressive symptoms and serum concentration of inflammatory cytokines (interleukin (IL)-1β, IL-6 and tumor necrosis factor-α) were measured at baseline and at the endpoint of rTMS treatment. rTMS treatment significantly improved depressive symptom scores and some subscales of cognitive dysfunction. The present study has demonstrated that partial changes in cognitive function and changes in IL-1β were significantly correlated. The partial improvement of cognitive dysfunction by rTMS in the present study might be attributable to the reduction of peripheral IL-1β levels. The present results should be replicated for verification in future studies.

Original language	English
Article number	112995
Journal	Psychiatry research
Volume	289
DOIs	https://doi.org/10.1016/j.psychres.2020.112995
Publication status	Published - Jul 2020

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.psychres.2020.112995

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Tateishi, H., Mizoguchi, Y., Kawaguchi, A., Imamura, Y., Matsushima, J., Kunitake, H., Murakawa, T., Haraguchi, Y., Kunitake, Y., Maekawa, T., Kato, T. A., Asami, T., & Monji, A. (2020). Changes in interleukin-1 beta induced by rTMS are significantly correlated with partial improvement of cognitive dysfunction in treatment-resistant depression: a pilot study. Psychiatry research, 289, [112995]. https://doi.org/10.1016/j.psychres.2020.112995

Tateishi, H, Mizoguchi, Y, Kawaguchi, A, Imamura, Y, Matsushima, J, Kunitake, H, Murakawa, T, Haraguchi, Y, Kunitake, Y, Maekawa, T, Kato, TA, Asami, T & Monji, A 2020, 'Changes in interleukin-1 beta induced by rTMS are significantly correlated with partial improvement of cognitive dysfunction in treatment-resistant depression: a pilot study', Psychiatry research, vol. 289, 112995. https://doi.org/10.1016/j.psychres.2020.112995

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title = "Changes in interleukin-1 beta induced by rTMS are significantly correlated with partial improvement of cognitive dysfunction in treatment-resistant depression: a pilot study",

abstract = "The impairment experienced by many individuals with depression is closely related to the cognitive symptoms of the disorder. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation method that provides a promising technique for improving cognitive symptoms in treatment-resistant depression (TRD). It has recently been demonstrated that TRD is associated with increased inflammatory process. In the present study, we investigated whether a relationship exists between changes in cognitive function and those in inflammatory cytokines before and after rTMS treatment. Eleven patients with TRD were enrolled in a high-frequency (10 Hz) rTMS study. Cognitive function, depressive symptoms and serum concentration of inflammatory cytokines (interleukin (IL)-1β, IL-6 and tumor necrosis factor-α) were measured at baseline and at the endpoint of rTMS treatment. rTMS treatment significantly improved depressive symptom scores and some subscales of cognitive dysfunction. The present study has demonstrated that partial changes in cognitive function and changes in IL-1β were significantly correlated. The partial improvement of cognitive dysfunction by rTMS in the present study might be attributable to the reduction of peripheral IL-1β levels. The present results should be replicated for verification in future studies.",

author = "Hiroshi Tateishi and Yoshito Mizoguchi and Atsushi Kawaguchi and Yoshiomi Imamura and Jun Matsushima and Hiroko Kunitake and Toru Murakawa and Yoshinori Haraguchi and Yutaka Kunitake and Toshihiko Maekawa and Kato, {Takahiro A.} and Toyoko Asami and Akira Monji",

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AU - Kato, Takahiro A.

AU - Asami, Toyoko

AU - Monji, Akira

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N2 - The impairment experienced by many individuals with depression is closely related to the cognitive symptoms of the disorder. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation method that provides a promising technique for improving cognitive symptoms in treatment-resistant depression (TRD). It has recently been demonstrated that TRD is associated with increased inflammatory process. In the present study, we investigated whether a relationship exists between changes in cognitive function and those in inflammatory cytokines before and after rTMS treatment. Eleven patients with TRD were enrolled in a high-frequency (10 Hz) rTMS study. Cognitive function, depressive symptoms and serum concentration of inflammatory cytokines (interleukin (IL)-1β, IL-6 and tumor necrosis factor-α) were measured at baseline and at the endpoint of rTMS treatment. rTMS treatment significantly improved depressive symptom scores and some subscales of cognitive dysfunction. The present study has demonstrated that partial changes in cognitive function and changes in IL-1β were significantly correlated. The partial improvement of cognitive dysfunction by rTMS in the present study might be attributable to the reduction of peripheral IL-1β levels. The present results should be replicated for verification in future studies.

AB - The impairment experienced by many individuals with depression is closely related to the cognitive symptoms of the disorder. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation method that provides a promising technique for improving cognitive symptoms in treatment-resistant depression (TRD). It has recently been demonstrated that TRD is associated with increased inflammatory process. In the present study, we investigated whether a relationship exists between changes in cognitive function and those in inflammatory cytokines before and after rTMS treatment. Eleven patients with TRD were enrolled in a high-frequency (10 Hz) rTMS study. Cognitive function, depressive symptoms and serum concentration of inflammatory cytokines (interleukin (IL)-1β, IL-6 and tumor necrosis factor-α) were measured at baseline and at the endpoint of rTMS treatment. rTMS treatment significantly improved depressive symptom scores and some subscales of cognitive dysfunction. The present study has demonstrated that partial changes in cognitive function and changes in IL-1β were significantly correlated. The partial improvement of cognitive dysfunction by rTMS in the present study might be attributable to the reduction of peripheral IL-1β levels. The present results should be replicated for verification in future studies.

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Changes in interleukin-1 beta induced by rTMS are significantly correlated with partial improvement of cognitive dysfunction in treatment-resistant depression: a pilot study

Abstract

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