Changes in the metabolites of cerebrospinal fluid induced by rTMS in treatment-resistant depression: A pilot study

Hiroshi Tateishi; Daiki Setoyama; Takahiro A. Kato; Dongchon Kang; Jun Matsushima; Kojiro Nogami; Seiji Mawatari; Ryohei Kojima; Yuka Fujii; Yuta Sakemura; Takumi Shiraishi; Yoshiomi Imamura; Toshihiko Maekawa; Toyoko Asami; Yoshito Mizoguchi; Akira Monji

doi:10.1016/j.psychres.2022.114636

Changes in the metabolites of cerebrospinal fluid induced by rTMS in treatment-resistant depression: A pilot study

Hiroshi Tateishi, Daiki Setoyama, Takahiro A. Kato, Dongchon Kang, Jun Matsushima, Kojiro Nogami, Seiji Mawatari, Ryohei Kojima, Yuka Fujii, Yuta Sakemura, Takumi Shiraishi, Yoshiomi Imamura, Toshihiko Maekawa, Toyoko Asami, Yoshito Mizoguchi, Akira Monji

Neuro-Psychiatry

Research output: Contribution to journal › Article › peer-review

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Abstract

Repetitive transcranial magnetic stimulation (rTMS) improves depressive symptoms in treatment-resistant depression (TRD). This study aimed to analyze changes in cerebrospinal fluid (CSF) metabolites in patients with TRD after rTMS. Five patients with TRD were enrolled in a high frequency (10-Hz) rTMS study. The concentration of 72 CSF metabolites were measured at baseline and at the end of the 6-week rTMS treatment. rTMS significantly increased CSF niacinamide, kynurenine, and creatinine levels and significantly decreased CSF cystine levels, but not the levels of the other 68 CSF metabolites. This is the first CSF metabolomics study on patients with TRD who underwent rTMS.

Original language	English
Article number	114636
Journal	Psychiatry research
Volume	313
DOIs	https://doi.org/10.1016/j.psychres.2022.114636
Publication status	Published - Jul 2022

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.psychres.2022.114636

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Tateishi, H., Setoyama, D., Kato, T. A., Kang, D., Matsushima, J., Nogami, K., Mawatari, S., Kojima, R., Fujii, Y., Sakemura, Y., Shiraishi, T., Imamura, Y., Maekawa, T., Asami, T., Mizoguchi, Y., & Monji, A. (2022). Changes in the metabolites of cerebrospinal fluid induced by rTMS in treatment-resistant depression: A pilot study. Psychiatry research, 313, [114636]. https://doi.org/10.1016/j.psychres.2022.114636

Tateishi, H, Setoyama, D , Kato, TA, Kang, D, Matsushima, J, Nogami, K, Mawatari, S, Kojima, R, Fujii, Y, Sakemura, Y, Shiraishi, T, Imamura, Y, Maekawa, T, Asami, T, Mizoguchi, Y & Monji, A 2022, 'Changes in the metabolites of cerebrospinal fluid induced by rTMS in treatment-resistant depression: A pilot study', Psychiatry research, vol. 313, 114636. https://doi.org/10.1016/j.psychres.2022.114636

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abstract = "Repetitive transcranial magnetic stimulation (rTMS) improves depressive symptoms in treatment-resistant depression (TRD). This study aimed to analyze changes in cerebrospinal fluid (CSF) metabolites in patients with TRD after rTMS. Five patients with TRD were enrolled in a high frequency (10-Hz) rTMS study. The concentration of 72 CSF metabolites were measured at baseline and at the end of the 6-week rTMS treatment. rTMS significantly increased CSF niacinamide, kynurenine, and creatinine levels and significantly decreased CSF cystine levels, but not the levels of the other 68 CSF metabolites. This is the first CSF metabolomics study on patients with TRD who underwent rTMS.",

author = "Hiroshi Tateishi and Daiki Setoyama and Kato, {Takahiro A.} and Dongchon Kang and Jun Matsushima and Kojiro Nogami and Seiji Mawatari and Ryohei Kojima and Yuka Fujii and Yuta Sakemura and Takumi Shiraishi and Yoshiomi Imamura and Toshihiko Maekawa and Toyoko Asami and Yoshito Mizoguchi and Akira Monji",

note = "Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research from (1) the Japan Society for the Promotion of Science (JSPS KAKENHI Grant Numbers JP17K10307 to H.T., JP16H06403 , JP18H04042 to T.A.K., JP18K07417 , and JP21K07369 to D.S.) and (2) the Japan Agency for Medical Research and Development (AMED) ( JP19dk0307047 , JP19dk0307075 , JP19dm0107095 , and JP21wm0425010 to T.A.K.). Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

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AU - Tateishi, Hiroshi

AU - Setoyama, Daiki

AU - Kato, Takahiro A.

AU - Kang, Dongchon

AU - Matsushima, Jun

AU - Nogami, Kojiro

AU - Mawatari, Seiji

AU - Kojima, Ryohei

AU - Fujii, Yuka

AU - Sakemura, Yuta

AU - Shiraishi, Takumi

AU - Imamura, Yoshiomi

AU - Maekawa, Toshihiko

AU - Asami, Toyoko

AU - Mizoguchi, Yoshito

AU - Monji, Akira

N1 - Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research from (1) the Japan Society for the Promotion of Science (JSPS KAKENHI Grant Numbers JP17K10307 to H.T., JP16H06403 , JP18H04042 to T.A.K., JP18K07417 , and JP21K07369 to D.S.) and (2) the Japan Agency for Medical Research and Development (AMED) ( JP19dk0307047 , JP19dk0307075 , JP19dm0107095 , and JP21wm0425010 to T.A.K.). Publisher Copyright: © 2022 Elsevier B.V.

PY - 2022/7

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N2 - Repetitive transcranial magnetic stimulation (rTMS) improves depressive symptoms in treatment-resistant depression (TRD). This study aimed to analyze changes in cerebrospinal fluid (CSF) metabolites in patients with TRD after rTMS. Five patients with TRD were enrolled in a high frequency (10-Hz) rTMS study. The concentration of 72 CSF metabolites were measured at baseline and at the end of the 6-week rTMS treatment. rTMS significantly increased CSF niacinamide, kynurenine, and creatinine levels and significantly decreased CSF cystine levels, but not the levels of the other 68 CSF metabolites. This is the first CSF metabolomics study on patients with TRD who underwent rTMS.

AB - Repetitive transcranial magnetic stimulation (rTMS) improves depressive symptoms in treatment-resistant depression (TRD). This study aimed to analyze changes in cerebrospinal fluid (CSF) metabolites in patients with TRD after rTMS. Five patients with TRD were enrolled in a high frequency (10-Hz) rTMS study. The concentration of 72 CSF metabolites were measured at baseline and at the end of the 6-week rTMS treatment. rTMS significantly increased CSF niacinamide, kynurenine, and creatinine levels and significantly decreased CSF cystine levels, but not the levels of the other 68 CSF metabolites. This is the first CSF metabolomics study on patients with TRD who underwent rTMS.

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Changes in the metabolites of cerebrospinal fluid induced by rTMS in treatment-resistant depression: A pilot study

Abstract

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