TY - JOUR
T1 - Changes in transient receptor potential vanilloid (TRPV) 1, 2, 3 and 4 expression in mouse inner ear following gentamicin challenge
AU - Ishibashi, Takuya
AU - Takumida, Masaya
AU - Akagi, Nana
AU - Hirakawa, Katsuhiro
AU - Anniko, Matti
N1 - Funding Information:
This study was supported by a Health and Labor Science Research Grant for Research on Specific Diseases (Vestibular Disorders) from the Japanese Ministry of Health, Labor and Welfare (2007), a Grant-in Aid for Scientific Research (19591972) provided by the Japanese Ministry of Education, Science and Culture, and also by a grant from the Swedish Medical Research Council (no. 17X-7305).
PY - 2009
Y1 - 2009
N2 - Conclusion. It is suggested that transient receptor potential vanilloid (TRPV)-1 and -2 may be of pathological significance for sensory cells and ganglions, while TRPV-3 and -4 may play an important part in neuroprotection of the inner ear. Objective. Changes in the expression of TRPV-1, -2, -3, and -4 in gentamicin (GM)-treated mouse inner ear were studied. Materials and methods. CBA/J mice were used in this study. The localization of TRPV-1, -2, -3, and -4 in the inner ear of both untreated and GM-treated CBA/J animals (intratympanic injection of 5 mg GM) was investigated by immunohistochemistry. Results. TRPV-1, -2, and -3 were co-expressed in the inner ear sensory and ganglion cells, while TRPV-4 was also expressed in the stria vascularis and vestibular dark cells. Following GM treatment, the intensity of immunofluorescent reaction to TRPV-1 and TRPV-2 increased, while that to TRPV-3 and TRPV-4 decreased.
AB - Conclusion. It is suggested that transient receptor potential vanilloid (TRPV)-1 and -2 may be of pathological significance for sensory cells and ganglions, while TRPV-3 and -4 may play an important part in neuroprotection of the inner ear. Objective. Changes in the expression of TRPV-1, -2, -3, and -4 in gentamicin (GM)-treated mouse inner ear were studied. Materials and methods. CBA/J mice were used in this study. The localization of TRPV-1, -2, -3, and -4 in the inner ear of both untreated and GM-treated CBA/J animals (intratympanic injection of 5 mg GM) was investigated by immunohistochemistry. Results. TRPV-1, -2, and -3 were co-expressed in the inner ear sensory and ganglion cells, while TRPV-4 was also expressed in the stria vascularis and vestibular dark cells. Following GM treatment, the intensity of immunofluorescent reaction to TRPV-1 and TRPV-2 increased, while that to TRPV-3 and TRPV-4 decreased.
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U2 - 10.1080/00016480802032835
DO - 10.1080/00016480802032835
M3 - Article
C2 - 18607956
AN - SCOPUS:60549094066
SN - 0001-6489
VL - 129
SP - 116
EP - 126
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
IS - 2
ER -