Changes in vascular properties, not ventricular properties, predominantly contribute to baroreflex regulation of arterial pressure

takafumi sakamoto, Takamori Kakino, Kazuo Sakamoto, Tomoyuki Tobushi, Atsushi Tanaka, Keita Saku, Kazuya Hosokawa, Ken Onitsuka, Yoshinori Murayama, Takaki Tsutsumi, Tomomi Ide, Kenji Sunagawa

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Baroreflex modulates both the ventricular and vascular properties and stabilizes arterial pressure (AP). However, how changes in those mechanical properties quantitatively impact the dynamic AP regulation remains unknown. We developed a framework of circulatory equilibrium, in which both venous return and cardiac output are expressed as functions of left ventricular (LV) end-systolic elastance (Ees), heart rate (HR), systemic vascular resistance (R), and stressed blood volume (V). We investigated the contribution of each mechanical property using the framework of circulatory equilibrium. In six anesthetized dogs, we vascularly isolated carotid sinuses and randomly changed carotid sinus pressure (CSP), while measuring the LV Ees, aortic flow, right and left atrial pressure, and AP for at least 60 min. We estimated transfer functions from CSP to Ees, HR, R, and V in each dog. We then predicted these parameters in response to changes in CSP from the transfer functions using a data set not used for identifying transfer functions and predicted changes in AP using the equilibrium framework. Predicted APs matched reasonably well with those measured (r2= 0.85–0.96, P < 0.001). Sensitivity analyses indicated that Ees and HR (ventricular properties) accounted for 14 ± 4 and 4 ± 2%, respectively, whereas R and V (vascular properties) accounted for 32 ± 4 and 39 ± 4%, respectively, of baroreflex-induced AP regulation. We concluded that baroreflex-induced dynamic AP changes can be accurately predicted by the transfer functions from CSP to mechanical properties using our framework of circulatory equilibrium. Changes in the vascular properties, not the ventricular properties, predominantly determine baroreflex-induced AP regulation.

Original languageEnglish
Pages (from-to)H49-H58
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume308
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

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Baroreflex
Carotid Sinus
Blood Vessels
Arterial Pressure
Pressure
Heart Rate
Dogs
Atrial Pressure
Blood Volume
Left Ventricular Function
Cardiac Output
Vascular Resistance

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Changes in vascular properties, not ventricular properties, predominantly contribute to baroreflex regulation of arterial pressure. / sakamoto, takafumi; Kakino, Takamori; Sakamoto, Kazuo; Tobushi, Tomoyuki; Tanaka, Atsushi; Saku, Keita; Hosokawa, Kazuya; Onitsuka, Ken; Murayama, Yoshinori; Tsutsumi, Takaki; Ide, Tomomi; Sunagawa, Kenji.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 308, No. 1, 01.01.2015, p. H49-H58.

Research output: Contribution to journalArticle

sakamoto, takafumi ; Kakino, Takamori ; Sakamoto, Kazuo ; Tobushi, Tomoyuki ; Tanaka, Atsushi ; Saku, Keita ; Hosokawa, Kazuya ; Onitsuka, Ken ; Murayama, Yoshinori ; Tsutsumi, Takaki ; Ide, Tomomi ; Sunagawa, Kenji. / Changes in vascular properties, not ventricular properties, predominantly contribute to baroreflex regulation of arterial pressure. In: American Journal of Physiology - Heart and Circulatory Physiology. 2015 ; Vol. 308, No. 1. pp. H49-H58.
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AB - Baroreflex modulates both the ventricular and vascular properties and stabilizes arterial pressure (AP). However, how changes in those mechanical properties quantitatively impact the dynamic AP regulation remains unknown. We developed a framework of circulatory equilibrium, in which both venous return and cardiac output are expressed as functions of left ventricular (LV) end-systolic elastance (Ees), heart rate (HR), systemic vascular resistance (R), and stressed blood volume (V). We investigated the contribution of each mechanical property using the framework of circulatory equilibrium. In six anesthetized dogs, we vascularly isolated carotid sinuses and randomly changed carotid sinus pressure (CSP), while measuring the LV Ees, aortic flow, right and left atrial pressure, and AP for at least 60 min. We estimated transfer functions from CSP to Ees, HR, R, and V in each dog. We then predicted these parameters in response to changes in CSP from the transfer functions using a data set not used for identifying transfer functions and predicted changes in AP using the equilibrium framework. Predicted APs matched reasonably well with those measured (r2= 0.85–0.96, P < 0.001). Sensitivity analyses indicated that Ees and HR (ventricular properties) accounted for 14 ± 4 and 4 ± 2%, respectively, whereas R and V (vascular properties) accounted for 32 ± 4 and 39 ± 4%, respectively, of baroreflex-induced AP regulation. We concluded that baroreflex-induced dynamic AP changes can be accurately predicted by the transfer functions from CSP to mechanical properties using our framework of circulatory equilibrium. Changes in the vascular properties, not the ventricular properties, predominantly determine baroreflex-induced AP regulation.

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