TY - JOUR
T1 - Changes of peripheral lymphocyte population in patients with chronic hepatitis C treated with herbal medicine (Maoto) and IFN-ß
AU - Kainuma, Mosaburo
AU - Kogure, Toshiaki
AU - Sekiya, Nobuyasu
AU - Mitsuma, Tadamichi
AU - Shimada, Yutaka
AU - Terasawa, Katsutoshi
PY - 2005/1/1
Y1 - 2005/1/1
N2 - We recently reported that the herbal medicine (Maoto) might have immunomodulatory effects when used in conjunction with IFN-β. In order to examine the relation between host immune reaction and virological effects upon treatment with Maoto and IFN-β, we monitored the changes in lymphocyte populations of peripheral Mood by flow-cytometry. Twenty-five patients with chronic hepatitis C were enrolled in this study. They received a daily dose of 6 mi ion units of IFN-β for 8 weeks. Maoto was given orally 4 times a day during the IFN-B administration, and we monitored the changes in lymphocyte populations of peripheral blood by flow-cytometry. Six patients were sustained virological responders (SR), 10 were transient responders (TR), and 9 were nonresponders (NR). The percentage of CD16+CD56+ lymphocyte populations was decreased in all groups between pretreatment and 4 weeks, but it was significantly increased in SR compared with TR and NR between 4 and 8 weeks. The percentage of HLADR+CD8+ lymphocyte populations was significantly increased in SR and TR compared with NR between pretreatment and 8 weeks. Our results suggested that monitoring of changes in peripheral CD16+CD56+ and HLADR+CD8+ lymphocyte populations could be useful to treat chronic hepatitis C with the combination therapy of Maoto and IFN-β.
AB - We recently reported that the herbal medicine (Maoto) might have immunomodulatory effects when used in conjunction with IFN-β. In order to examine the relation between host immune reaction and virological effects upon treatment with Maoto and IFN-β, we monitored the changes in lymphocyte populations of peripheral Mood by flow-cytometry. Twenty-five patients with chronic hepatitis C were enrolled in this study. They received a daily dose of 6 mi ion units of IFN-β for 8 weeks. Maoto was given orally 4 times a day during the IFN-B administration, and we monitored the changes in lymphocyte populations of peripheral blood by flow-cytometry. Six patients were sustained virological responders (SR), 10 were transient responders (TR), and 9 were nonresponders (NR). The percentage of CD16+CD56+ lymphocyte populations was decreased in all groups between pretreatment and 4 weeks, but it was significantly increased in SR compared with TR and NR between 4 and 8 weeks. The percentage of HLADR+CD8+ lymphocyte populations was significantly increased in SR and TR compared with NR between pretreatment and 8 weeks. Our results suggested that monitoring of changes in peripheral CD16+CD56+ and HLADR+CD8+ lymphocyte populations could be useful to treat chronic hepatitis C with the combination therapy of Maoto and IFN-β.
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U2 - 10.11339/jtm.22.29
DO - 10.11339/jtm.22.29
M3 - Article
AN - SCOPUS:77953840880
VL - 22
SP - 29
EP - 33
JO - Journal of Traditional Medicines
JF - Journal of Traditional Medicines
SN - 1880-1447
IS - 42403
ER -
