Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: An Asian Network for Surveillance of Resistant Pathogens (ANSORP) study

So Hyun Kim, Jae Hoon Song, Doo Ryeon Chung, Visanu Thamlikitkul, Yonghong Yang, Hui Wang, Min Lu, Thomas Man Kit So, Po Ren Hsueh, Rohani M. Yasin, Celia C. Carlos, Hung Van Pham, M. K. Lalitha, Nobuyuki Shimono, Jennifer Perera, Atef M. Shibl, Jin Yang Baek, Cheol In Kang, Kwan Soo Ko, Kyong Ran Peck

Research output: Contribution to journalArticle

196 Citations (Scopus)

Abstract

Antimicrobial resistance in Streptococcus pneumoniae remains a serious concern worldwide, particularly in Asian countries, despite the introduction of heptavalent pneumococcal conjugate vaccine (PCV7). The Asian Network for Surveillance of Resistant Pathogens (ANSORP) performed a prospective surveillance study of 2,184 S. pneumoniae isolates collected from patients with pneumococcal infections from 60 hospitals in 11 Asian countries from 2008 to 2009. Among nonmeningeal isolates, the prevalence rate of penicillin- nonsusceptible pneumococci (MIC,≥4 μg/ml) was 4.6% and penicillin resistance (MIC,≥8 μg/ml) was extremely rare (0.7%). Resistance to erythromycin was very prevalent in the region (72.7%); the highest rates were in China (96.4%), Taiwan (84.9%), and Vietnam (80.7%). Multidrug resistance (MDR) was observed in 59.3% of isolates from Asian countries. Major serotypes were 19F (23.5%), 23F (10.0%), 19A (8.2%), 14 (7.3%), and 6B (7.3%). Overall, 52.5% of isolates showed PCV7 serotypes, ranging from 16.1% in Philippines to 75.1% in Vietnam. Serotypes 19A (8.2%), 3 (6.2%), and 6A (4.2%) were the most prominent non-PCV7 serotypes in the Asian region. Among isolates with serotype 19A, 86.0% and 79.8% showed erythromycin resistance and MDR, respectively. The most remarkable findings about the epidemiology of S. pneumoniae in Asian countries after the introduction of PCV7 were the high prevalence of macrolide resistance and MDR and distinctive increases in serotype 19A.

Original languageEnglish
Pages (from-to)1418-1426
Number of pages9
JournalAntimicrobial Agents and Chemotherapy
Volume56
Issue number3
DOIs
Publication statusPublished - Mar 1 2012

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Streptococcus pneumoniae
Multiple Drug Resistance
Vietnam
Erythromycin
Penicillin Resistance
Pneumococcal Infections
Philippines
Macrolides
Taiwan
Penicillins
Serogroup
China
Epidemiology
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries : An Asian Network for Surveillance of Resistant Pathogens (ANSORP) study. / Kim, So Hyun; Song, Jae Hoon; Chung, Doo Ryeon; Thamlikitkul, Visanu; Yang, Yonghong; Wang, Hui; Lu, Min; So, Thomas Man Kit; Hsueh, Po Ren; Yasin, Rohani M.; Carlos, Celia C.; Van Pham, Hung; Lalitha, M. K.; Shimono, Nobuyuki; Perera, Jennifer; Shibl, Atef M.; Baek, Jin Yang; Kang, Cheol In; Ko, Kwan Soo; Peck, Kyong Ran.

In: Antimicrobial Agents and Chemotherapy, Vol. 56, No. 3, 01.03.2012, p. 1418-1426.

Research output: Contribution to journalArticle

Kim, SH, Song, JH, Chung, DR, Thamlikitkul, V, Yang, Y, Wang, H, Lu, M, So, TMK, Hsueh, PR, Yasin, RM, Carlos, CC, Van Pham, H, Lalitha, MK, Shimono, N, Perera, J, Shibl, AM, Baek, JY, Kang, CI, Ko, KS & Peck, KR 2012, 'Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: An Asian Network for Surveillance of Resistant Pathogens (ANSORP) study', Antimicrobial Agents and Chemotherapy, vol. 56, no. 3, pp. 1418-1426. https://doi.org/10.1128/AAC.05658-11
Kim, So Hyun ; Song, Jae Hoon ; Chung, Doo Ryeon ; Thamlikitkul, Visanu ; Yang, Yonghong ; Wang, Hui ; Lu, Min ; So, Thomas Man Kit ; Hsueh, Po Ren ; Yasin, Rohani M. ; Carlos, Celia C. ; Van Pham, Hung ; Lalitha, M. K. ; Shimono, Nobuyuki ; Perera, Jennifer ; Shibl, Atef M. ; Baek, Jin Yang ; Kang, Cheol In ; Ko, Kwan Soo ; Peck, Kyong Ran. / Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries : An Asian Network for Surveillance of Resistant Pathogens (ANSORP) study. In: Antimicrobial Agents and Chemotherapy. 2012 ; Vol. 56, No. 3. pp. 1418-1426.
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AU - Chung, Doo Ryeon

AU - Thamlikitkul, Visanu

AU - Yang, Yonghong

AU - Wang, Hui

AU - Lu, Min

AU - So, Thomas Man Kit

AU - Hsueh, Po Ren

AU - Yasin, Rohani M.

AU - Carlos, Celia C.

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AU - Perera, Jennifer

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