Characteristics and predictors of mortality in patients with cardiovascular shock in Japan - Results from the Japanese circulation society cardiovascular shock registry

Yasushi Ueki, Masahiro Mohri, Tetsuya Matoba, Yasuyuki Tsujita, Masao Yamasaki, Eizo Tachibana, Naohiro Yonemoto, Ken Nagao

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: There are little data about cardiovascular shock caused by various diseases. We evaluated the characteristics and predictors of 30-day mortality in patients with cardiovascular shock in Japan. Methods and Results: The Japanese Circulation Society Cardiovascular Shock registry was a prospective, observational, multicenter, cohort study. Between May 2012 and June 2014, 979 patients with cardiovascular shock were analyzed. The primary endpoint was 30-day all-cause mortality. The mean systolic blood pressure on hospital arrival was 78±18 mmHg. The main causes of shock were acute coronary syndrome (51.0%), non-ischemic arrhythmia (16.4%), and aortic disease (14.9%). The 30-day all-cause mortality was 34.3%. After adjustment for independent predictors of 30-day mortality, the odds ratios for systolic blood pressure (per 10-mmHg decrease), consciousness disturbance, congestive heart failure, out-of-hospital cardiac arrest, estimated glomerular filtration rate (per 10-ml/ min/1.73 m2 decrease), and causes of shock (non-ischemic arrhythmia, aortic disease, and myocarditis) were 1.15 (95% confidence interval [CI], 1.08-1.22), 2.62 (95% CI, 1.80-3.82), 2.58 (95% CI, 1.67-3.99), 1.62 (95% CI, 1.05-2.51), 1.20 (95% CI, 1.10-1.30), and 0.48 (95% CI, 0.30-0.77), 3.98 (95% CI, 2.32-6.81), and 3.25 (95% CI, 1.20-8.84), respectively. Conclusions: The 30-day mortality for cardiovascular shock was still high at 34%. Primary predictors of mortality were cardiorenal function on hospital arrival and shock etiology.

Original languageEnglish
Pages (from-to)852-859
Number of pages8
JournalCirculation Journal
Volume80
Issue number4
DOIs
Publication statusPublished - Mar 25 2016

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Registries
Shock
Japan
Confidence Intervals
Mortality
Blood Pressure
Aortic Diseases
Cardiac Arrhythmias
Out-of-Hospital Cardiac Arrest
Myocarditis
Acute Coronary Syndrome
Consciousness
Glomerular Filtration Rate
Multicenter Studies
Cohort Studies
Heart Failure
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Characteristics and predictors of mortality in patients with cardiovascular shock in Japan - Results from the Japanese circulation society cardiovascular shock registry. / Ueki, Yasushi; Mohri, Masahiro; Matoba, Tetsuya; Tsujita, Yasuyuki; Yamasaki, Masao; Tachibana, Eizo; Yonemoto, Naohiro; Nagao, Ken.

In: Circulation Journal, Vol. 80, No. 4, 25.03.2016, p. 852-859.

Research output: Contribution to journalArticle

Ueki, Yasushi ; Mohri, Masahiro ; Matoba, Tetsuya ; Tsujita, Yasuyuki ; Yamasaki, Masao ; Tachibana, Eizo ; Yonemoto, Naohiro ; Nagao, Ken. / Characteristics and predictors of mortality in patients with cardiovascular shock in Japan - Results from the Japanese circulation society cardiovascular shock registry. In: Circulation Journal. 2016 ; Vol. 80, No. 4. pp. 852-859.
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abstract = "Background: There are little data about cardiovascular shock caused by various diseases. We evaluated the characteristics and predictors of 30-day mortality in patients with cardiovascular shock in Japan. Methods and Results: The Japanese Circulation Society Cardiovascular Shock registry was a prospective, observational, multicenter, cohort study. Between May 2012 and June 2014, 979 patients with cardiovascular shock were analyzed. The primary endpoint was 30-day all-cause mortality. The mean systolic blood pressure on hospital arrival was 78±18 mmHg. The main causes of shock were acute coronary syndrome (51.0{\%}), non-ischemic arrhythmia (16.4{\%}), and aortic disease (14.9{\%}). The 30-day all-cause mortality was 34.3{\%}. After adjustment for independent predictors of 30-day mortality, the odds ratios for systolic blood pressure (per 10-mmHg decrease), consciousness disturbance, congestive heart failure, out-of-hospital cardiac arrest, estimated glomerular filtration rate (per 10-ml/ min/1.73 m2 decrease), and causes of shock (non-ischemic arrhythmia, aortic disease, and myocarditis) were 1.15 (95{\%} confidence interval [CI], 1.08-1.22), 2.62 (95{\%} CI, 1.80-3.82), 2.58 (95{\%} CI, 1.67-3.99), 1.62 (95{\%} CI, 1.05-2.51), 1.20 (95{\%} CI, 1.10-1.30), and 0.48 (95{\%} CI, 0.30-0.77), 3.98 (95{\%} CI, 2.32-6.81), and 3.25 (95{\%} CI, 1.20-8.84), respectively. Conclusions: The 30-day mortality for cardiovascular shock was still high at 34{\%}. Primary predictors of mortality were cardiorenal function on hospital arrival and shock etiology.",
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T1 - Characteristics and predictors of mortality in patients with cardiovascular shock in Japan - Results from the Japanese circulation society cardiovascular shock registry

AU - Ueki, Yasushi

AU - Mohri, Masahiro

AU - Matoba, Tetsuya

AU - Tsujita, Yasuyuki

AU - Yamasaki, Masao

AU - Tachibana, Eizo

AU - Yonemoto, Naohiro

AU - Nagao, Ken

PY - 2016/3/25

Y1 - 2016/3/25

N2 - Background: There are little data about cardiovascular shock caused by various diseases. We evaluated the characteristics and predictors of 30-day mortality in patients with cardiovascular shock in Japan. Methods and Results: The Japanese Circulation Society Cardiovascular Shock registry was a prospective, observational, multicenter, cohort study. Between May 2012 and June 2014, 979 patients with cardiovascular shock were analyzed. The primary endpoint was 30-day all-cause mortality. The mean systolic blood pressure on hospital arrival was 78±18 mmHg. The main causes of shock were acute coronary syndrome (51.0%), non-ischemic arrhythmia (16.4%), and aortic disease (14.9%). The 30-day all-cause mortality was 34.3%. After adjustment for independent predictors of 30-day mortality, the odds ratios for systolic blood pressure (per 10-mmHg decrease), consciousness disturbance, congestive heart failure, out-of-hospital cardiac arrest, estimated glomerular filtration rate (per 10-ml/ min/1.73 m2 decrease), and causes of shock (non-ischemic arrhythmia, aortic disease, and myocarditis) were 1.15 (95% confidence interval [CI], 1.08-1.22), 2.62 (95% CI, 1.80-3.82), 2.58 (95% CI, 1.67-3.99), 1.62 (95% CI, 1.05-2.51), 1.20 (95% CI, 1.10-1.30), and 0.48 (95% CI, 0.30-0.77), 3.98 (95% CI, 2.32-6.81), and 3.25 (95% CI, 1.20-8.84), respectively. Conclusions: The 30-day mortality for cardiovascular shock was still high at 34%. Primary predictors of mortality were cardiorenal function on hospital arrival and shock etiology.

AB - Background: There are little data about cardiovascular shock caused by various diseases. We evaluated the characteristics and predictors of 30-day mortality in patients with cardiovascular shock in Japan. Methods and Results: The Japanese Circulation Society Cardiovascular Shock registry was a prospective, observational, multicenter, cohort study. Between May 2012 and June 2014, 979 patients with cardiovascular shock were analyzed. The primary endpoint was 30-day all-cause mortality. The mean systolic blood pressure on hospital arrival was 78±18 mmHg. The main causes of shock were acute coronary syndrome (51.0%), non-ischemic arrhythmia (16.4%), and aortic disease (14.9%). The 30-day all-cause mortality was 34.3%. After adjustment for independent predictors of 30-day mortality, the odds ratios for systolic blood pressure (per 10-mmHg decrease), consciousness disturbance, congestive heart failure, out-of-hospital cardiac arrest, estimated glomerular filtration rate (per 10-ml/ min/1.73 m2 decrease), and causes of shock (non-ischemic arrhythmia, aortic disease, and myocarditis) were 1.15 (95% confidence interval [CI], 1.08-1.22), 2.62 (95% CI, 1.80-3.82), 2.58 (95% CI, 1.67-3.99), 1.62 (95% CI, 1.05-2.51), 1.20 (95% CI, 1.10-1.30), and 0.48 (95% CI, 0.30-0.77), 3.98 (95% CI, 2.32-6.81), and 3.25 (95% CI, 1.20-8.84), respectively. Conclusions: The 30-day mortality for cardiovascular shock was still high at 34%. Primary predictors of mortality were cardiorenal function on hospital arrival and shock etiology.

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