Characteristics and prognosis of Japanese female breast cancer patients

The BioBank Japan project

Biobank Japan Cooperative Hospital Group

Research output: Contribution to journalArticle

Abstract

Background: Breast cancer is currently the most common type of cancer in Japanese females. Unlike most other types of cancer, breast cancer develops more frequently in middle-aged females than in elderly females. Methods: Of all Japanese female breast cancer patients aged ≥ 20 years whom the BioBank Japan Project originally enrolled between 2003 and 2008, 2034 were registered within 90 days after their diagnosis. We described the lifestyle and clinical characteristics of these patients at study entry. Furthermore, we examined the effect of these characteristics on all-cause mortality. Results: In the female patients registered within 90 days after diagnosis, the frequency of stage 0 or unclassified, stage I, II, III and IV were 11.4%, 47.9%, 37.0%, 2.9% and 0.8%, respectively. The proportion of histological types was 12.9% for non-invasive carcinoma (ductal carcinoma and lobular carcinoma), 81.0% for invasive carcinoma (papillotubular carcinoma, solid tubular carcinoma, scirrhous carcinoma and special types), 0.2% for Paget's diseases and 5.8% for others. Those positive for the estrogen and progesterone receptors accounted for 75.8% and 62.1% of all patients, respectively. Among 1860 female participants registered within 90 days, 218 participants died during 144,54 person-years of follow-up. More advanced stage, elevation of serum carcinoembryonic antigen and carbohydrate antigen 15-3 levels and absence of the estrogen receptor at study entry were crudely associated with an increased risk of all-cause mortality after adjustment for age. Conclusions: This study showed the association of several clinical characteristics with all-cause mortality in female breast cancer patients.

Original languageEnglish
Pages (from-to)S98-S106
JournalJournal of epidemiology
Volume27
DOIs
Publication statusPublished - Jan 1 2017

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Japan
Breast Neoplasms
Carcinoma
Estrogen Receptors
Mortality
Scirrhous Adenocarcinoma
Lobular Carcinoma
Ductal Carcinoma
Carcinoembryonic Antigen
Progesterone Receptors
Life Style
Adenocarcinoma
Carbohydrates
Antigens
Serum
Neoplasms

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Characteristics and prognosis of Japanese female breast cancer patients : The BioBank Japan project. / Biobank Japan Cooperative Hospital Group.

In: Journal of epidemiology, Vol. 27, 01.01.2017, p. S98-S106.

Research output: Contribution to journalArticle

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title = "Characteristics and prognosis of Japanese female breast cancer patients: The BioBank Japan project",
abstract = "Background: Breast cancer is currently the most common type of cancer in Japanese females. Unlike most other types of cancer, breast cancer develops more frequently in middle-aged females than in elderly females. Methods: Of all Japanese female breast cancer patients aged ≥ 20 years whom the BioBank Japan Project originally enrolled between 2003 and 2008, 2034 were registered within 90 days after their diagnosis. We described the lifestyle and clinical characteristics of these patients at study entry. Furthermore, we examined the effect of these characteristics on all-cause mortality. Results: In the female patients registered within 90 days after diagnosis, the frequency of stage 0 or unclassified, stage I, II, III and IV were 11.4{\%}, 47.9{\%}, 37.0{\%}, 2.9{\%} and 0.8{\%}, respectively. The proportion of histological types was 12.9{\%} for non-invasive carcinoma (ductal carcinoma and lobular carcinoma), 81.0{\%} for invasive carcinoma (papillotubular carcinoma, solid tubular carcinoma, scirrhous carcinoma and special types), 0.2{\%} for Paget's diseases and 5.8{\%} for others. Those positive for the estrogen and progesterone receptors accounted for 75.8{\%} and 62.1{\%} of all patients, respectively. Among 1860 female participants registered within 90 days, 218 participants died during 144,54 person-years of follow-up. More advanced stage, elevation of serum carcinoembryonic antigen and carbohydrate antigen 15-3 levels and absence of the estrogen receptor at study entry were crudely associated with an increased risk of all-cause mortality after adjustment for age. Conclusions: This study showed the association of several clinical characteristics with all-cause mortality in female breast cancer patients.",
author = "{Biobank Japan Cooperative Hospital Group} and Koshi Nakamura and Emiko Okada and Shigekazu Ukawa and Makoto Hirata and Akiko Nagai and Zentaro Yamagata and Yutaka Kiyohara and Kaori Muto and Yoichiro Kamatani and Toshiharu Ninomiya and Koichi Matsuda and Michiaki Kubo and Yusuke Nakamura and Akiko Tamakoshi and Hiromasa Harada and Sunao Matsubayashi and Rieko Komi and Kazuo Misumi and Shiro Minami and Hitoshi Sugihara and Eitaro Kodani and Akio Kanazawa and Hiromasa Gotoh and Hidenori Haruna and Satoshi Asai and Mitsuhiko Moriyama and Yasuo Takahashi and Tomoaki Fujioka and Wataru Obara and Seijiro Mori and Hideki Ito and Satoshi Nagayama and Yoshio Miki and Akihide Masumoto and Akira Yamada and Yasuko Nishizawa and Ken Kodama and Satoshi Ugi and Shinichi Araki and Yukihiro Koretsune and Hideki Taki and Takayuki Nakagawa",
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issn = "0917-5040",
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T1 - Characteristics and prognosis of Japanese female breast cancer patients

T2 - The BioBank Japan project

AU - Biobank Japan Cooperative Hospital Group

AU - Nakamura, Koshi

AU - Okada, Emiko

AU - Ukawa, Shigekazu

AU - Hirata, Makoto

AU - Nagai, Akiko

AU - Yamagata, Zentaro

AU - Kiyohara, Yutaka

AU - Muto, Kaori

AU - Kamatani, Yoichiro

AU - Ninomiya, Toshiharu

AU - Matsuda, Koichi

AU - Kubo, Michiaki

AU - Nakamura, Yusuke

AU - Tamakoshi, Akiko

AU - Harada, Hiromasa

AU - Matsubayashi, Sunao

AU - Komi, Rieko

AU - Misumi, Kazuo

AU - Minami, Shiro

AU - Sugihara, Hitoshi

AU - Kodani, Eitaro

AU - Kanazawa, Akio

AU - Gotoh, Hiromasa

AU - Haruna, Hidenori

AU - Asai, Satoshi

AU - Moriyama, Mitsuhiko

AU - Takahashi, Yasuo

AU - Fujioka, Tomoaki

AU - Obara, Wataru

AU - Mori, Seijiro

AU - Ito, Hideki

AU - Nagayama, Satoshi

AU - Miki, Yoshio

AU - Masumoto, Akihide

AU - Yamada, Akira

AU - Nishizawa, Yasuko

AU - Kodama, Ken

AU - Ugi, Satoshi

AU - Araki, Shinichi

AU - Koretsune, Yukihiro

AU - Taki, Hideki

AU - Nakagawa, Takayuki

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Breast cancer is currently the most common type of cancer in Japanese females. Unlike most other types of cancer, breast cancer develops more frequently in middle-aged females than in elderly females. Methods: Of all Japanese female breast cancer patients aged ≥ 20 years whom the BioBank Japan Project originally enrolled between 2003 and 2008, 2034 were registered within 90 days after their diagnosis. We described the lifestyle and clinical characteristics of these patients at study entry. Furthermore, we examined the effect of these characteristics on all-cause mortality. Results: In the female patients registered within 90 days after diagnosis, the frequency of stage 0 or unclassified, stage I, II, III and IV were 11.4%, 47.9%, 37.0%, 2.9% and 0.8%, respectively. The proportion of histological types was 12.9% for non-invasive carcinoma (ductal carcinoma and lobular carcinoma), 81.0% for invasive carcinoma (papillotubular carcinoma, solid tubular carcinoma, scirrhous carcinoma and special types), 0.2% for Paget's diseases and 5.8% for others. Those positive for the estrogen and progesterone receptors accounted for 75.8% and 62.1% of all patients, respectively. Among 1860 female participants registered within 90 days, 218 participants died during 144,54 person-years of follow-up. More advanced stage, elevation of serum carcinoembryonic antigen and carbohydrate antigen 15-3 levels and absence of the estrogen receptor at study entry were crudely associated with an increased risk of all-cause mortality after adjustment for age. Conclusions: This study showed the association of several clinical characteristics with all-cause mortality in female breast cancer patients.

AB - Background: Breast cancer is currently the most common type of cancer in Japanese females. Unlike most other types of cancer, breast cancer develops more frequently in middle-aged females than in elderly females. Methods: Of all Japanese female breast cancer patients aged ≥ 20 years whom the BioBank Japan Project originally enrolled between 2003 and 2008, 2034 were registered within 90 days after their diagnosis. We described the lifestyle and clinical characteristics of these patients at study entry. Furthermore, we examined the effect of these characteristics on all-cause mortality. Results: In the female patients registered within 90 days after diagnosis, the frequency of stage 0 or unclassified, stage I, II, III and IV were 11.4%, 47.9%, 37.0%, 2.9% and 0.8%, respectively. The proportion of histological types was 12.9% for non-invasive carcinoma (ductal carcinoma and lobular carcinoma), 81.0% for invasive carcinoma (papillotubular carcinoma, solid tubular carcinoma, scirrhous carcinoma and special types), 0.2% for Paget's diseases and 5.8% for others. Those positive for the estrogen and progesterone receptors accounted for 75.8% and 62.1% of all patients, respectively. Among 1860 female participants registered within 90 days, 218 participants died during 144,54 person-years of follow-up. More advanced stage, elevation of serum carcinoembryonic antigen and carbohydrate antigen 15-3 levels and absence of the estrogen receptor at study entry were crudely associated with an increased risk of all-cause mortality after adjustment for age. Conclusions: This study showed the association of several clinical characteristics with all-cause mortality in female breast cancer patients.

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U2 - 10.1016/j.je.2016.12.012

DO - 10.1016/j.je.2016.12.012

M3 - Article

VL - 27

SP - S98-S106

JO - Journal of Epidemiology

JF - Journal of Epidemiology

SN - 0917-5040

ER -