Characteristics of olfactory dysfunction in patients with temporal lobe epilepsy

Ayako Motoki, Naoki Akamatsu, Tomoyuki Fumuro, Ayako Miyoshi, Hideaki Tanaka, Koichi Hagiwara, Shinji Ohara, Takashi Kamada, Hiroshi Shigeto, Hiroyuki Murai

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To determine the characteristics of olfactory dysfunction in patients with temporal lobe epilepsy (TLE). Methods: Odor identification was assessed using the odor stick identification test for Japanese (OSIT-J, full score 12 points) in 65 patients with TLE and in 74 controls. Results: The mean OSIT-J score was significantly lower in patients with TLE (mean ± SD = 8.1 ± 2.8; median = 9) than in the control subjects (mean ± SD = 10.6 ± 1.1; median = 11) (P < 0.005). Olfactory dysfunction (hyposmia/anosmia) was associated with bilateral seizure foci and older age of onset in TLE. Patients who underwent temporal lobectomy for hippocampal sclerosis did not show significant decline after long-term recovery. The Indian ink part of OSIT-J was useful for the detection of olfactory deficits in patients with TLE (sensitivity = 47%, specificity = 93%). Patients with TLE tended to have preserved olfactory ability for stimulating odors and for familiar odors of daily life. Significance: We observed characteristic odor identification deficits for individual odors used in OSIT-J. Our study findings provide deeper insight into the underlying mechanism of olfactory function in patients with TLE and may be beneficial in the clinical management of these patients.

Original languageEnglish
Article number108402
JournalEpilepsy and Behavior
Volume125
DOIs
Publication statusPublished - Dec 2021

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

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