TY - JOUR
T1 - Characteristics of olfactory dysfunction in patients with temporal lobe epilepsy
AU - Motoki, Ayako
AU - Akamatsu, Naoki
AU - Fumuro, Tomoyuki
AU - Miyoshi, Ayako
AU - Tanaka, Hideaki
AU - Hagiwara, Koichi
AU - Ohara, Shinji
AU - Kamada, Takashi
AU - Shigeto, Hiroshi
AU - Murai, Hiroyuki
N1 - Funding Information:
We would like to express our thanks and appreciation to all the patients who have participated. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. This research did not receive any specific grant from funding agencies in the public, commercial, or non-profit sectors.
Publisher Copyright:
© 2021 The Author(s)
PY - 2021/12
Y1 - 2021/12
N2 - Objective: To determine the characteristics of olfactory dysfunction in patients with temporal lobe epilepsy (TLE). Methods: Odor identification was assessed using the odor stick identification test for Japanese (OSIT-J, full score 12 points) in 65 patients with TLE and in 74 controls. Results: The mean OSIT-J score was significantly lower in patients with TLE (mean ± SD = 8.1 ± 2.8; median = 9) than in the control subjects (mean ± SD = 10.6 ± 1.1; median = 11) (P < 0.005). Olfactory dysfunction (hyposmia/anosmia) was associated with bilateral seizure foci and older age of onset in TLE. Patients who underwent temporal lobectomy for hippocampal sclerosis did not show significant decline after long-term recovery. The Indian ink part of OSIT-J was useful for the detection of olfactory deficits in patients with TLE (sensitivity = 47%, specificity = 93%). Patients with TLE tended to have preserved olfactory ability for stimulating odors and for familiar odors of daily life. Significance: We observed characteristic odor identification deficits for individual odors used in OSIT-J. Our study findings provide deeper insight into the underlying mechanism of olfactory function in patients with TLE and may be beneficial in the clinical management of these patients.
AB - Objective: To determine the characteristics of olfactory dysfunction in patients with temporal lobe epilepsy (TLE). Methods: Odor identification was assessed using the odor stick identification test for Japanese (OSIT-J, full score 12 points) in 65 patients with TLE and in 74 controls. Results: The mean OSIT-J score was significantly lower in patients with TLE (mean ± SD = 8.1 ± 2.8; median = 9) than in the control subjects (mean ± SD = 10.6 ± 1.1; median = 11) (P < 0.005). Olfactory dysfunction (hyposmia/anosmia) was associated with bilateral seizure foci and older age of onset in TLE. Patients who underwent temporal lobectomy for hippocampal sclerosis did not show significant decline after long-term recovery. The Indian ink part of OSIT-J was useful for the detection of olfactory deficits in patients with TLE (sensitivity = 47%, specificity = 93%). Patients with TLE tended to have preserved olfactory ability for stimulating odors and for familiar odors of daily life. Significance: We observed characteristic odor identification deficits for individual odors used in OSIT-J. Our study findings provide deeper insight into the underlying mechanism of olfactory function in patients with TLE and may be beneficial in the clinical management of these patients.
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U2 - 10.1016/j.yebeh.2021.108402
DO - 10.1016/j.yebeh.2021.108402
M3 - Article
AN - SCOPUS:85118855405
VL - 125
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
SN - 1525-5050
M1 - 108402
ER -