Abstract
OBJECTIVE: Although patients with autoimmune pancreatitis (AIP) tend to have concurrent diverse disorders, very few studies have focused on diabetes mellitus (DM) coexisting with AIP. METHODS: In total 102 AIP patients with DM were divided into three groups. Those with DM before the onset of AIP were labeled group A (n=35), those who developed DM and AIP simultaneously were labeled group B (n=58) and those who developed DM after steroid therapy for AIP were labeled group C (n=9). The characteristics of DM among the three groups were evaluated. RESULTS: No significant differences were noted in the age of DM onset among the three groups. However, the mean duration of DM was significantly longer in group A (8.7 years) than in groups B and C. AIP developed 6.8 years after DM onset in group A, whereas it developed 1.8 years after steroid therapy in group C. Group A had the highest rate (25.7%) of family members with a history of AIP. Levels of serum albumin, total cholesterol and triglyceride were significantly lower in group A. No correlations were found between glycated hemoglobin and benzoyl-tyrosyl para-aminobenzoic acid. Hypoglycemia was observed in 20% of patients under insulin therapy. Most of them were habitual drinkers and received no pancreatic enzymes. Group A showed a high prevalence of retinopathy, nephropathy and macrovascular disorders than group B. CONCLUSION: Aspects of AIP-associated pancreatic diabetes were clarified. AIP-associated DM must be controlled by a full assessment of the pancreatic endocrine and exocrine function.
| Original language | English |
|---|---|
| Pages (from-to) | 210-216 |
| Number of pages | 7 |
| Journal | Journal of Digestive Diseases |
| Volume | 12 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 1 2011 |
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All Science Journal Classification (ASJC) codes
- Gastroenterology
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Characteristics of pancreatic diabetes in patients with autoimmune pancreatitis. / Ito, Tetsuhide; Nakamura, Taichi; Fujimori, Nao; Niina, Yusuke; Igarashi, Hisato; Oono, Takamasa; Uchida, Masahiko; Kawabe, Ken; Takayanagi, Ryoichi; Nishimori, Isao; Otsuki, Makoto; Shimosegawa, Tooru.
In: Journal of Digestive Diseases, Vol. 12, No. 3, 01.06.2011, p. 210-216.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Characteristics of pancreatic diabetes in patients with autoimmune pancreatitis
AU - Ito, Tetsuhide
AU - Nakamura, Taichi
AU - Fujimori, Nao
AU - Niina, Yusuke
AU - Igarashi, Hisato
AU - Oono, Takamasa
AU - Uchida, Masahiko
AU - Kawabe, Ken
AU - Takayanagi, Ryoichi
AU - Nishimori, Isao
AU - Otsuki, Makoto
AU - Shimosegawa, Tooru
PY - 2011/6/1
Y1 - 2011/6/1
N2 - OBJECTIVE: Although patients with autoimmune pancreatitis (AIP) tend to have concurrent diverse disorders, very few studies have focused on diabetes mellitus (DM) coexisting with AIP. METHODS: In total 102 AIP patients with DM were divided into three groups. Those with DM before the onset of AIP were labeled group A (n=35), those who developed DM and AIP simultaneously were labeled group B (n=58) and those who developed DM after steroid therapy for AIP were labeled group C (n=9). The characteristics of DM among the three groups were evaluated. RESULTS: No significant differences were noted in the age of DM onset among the three groups. However, the mean duration of DM was significantly longer in group A (8.7 years) than in groups B and C. AIP developed 6.8 years after DM onset in group A, whereas it developed 1.8 years after steroid therapy in group C. Group A had the highest rate (25.7%) of family members with a history of AIP. Levels of serum albumin, total cholesterol and triglyceride were significantly lower in group A. No correlations were found between glycated hemoglobin and benzoyl-tyrosyl para-aminobenzoic acid. Hypoglycemia was observed in 20% of patients under insulin therapy. Most of them were habitual drinkers and received no pancreatic enzymes. Group A showed a high prevalence of retinopathy, nephropathy and macrovascular disorders than group B. CONCLUSION: Aspects of AIP-associated pancreatic diabetes were clarified. AIP-associated DM must be controlled by a full assessment of the pancreatic endocrine and exocrine function.
AB - OBJECTIVE: Although patients with autoimmune pancreatitis (AIP) tend to have concurrent diverse disorders, very few studies have focused on diabetes mellitus (DM) coexisting with AIP. METHODS: In total 102 AIP patients with DM were divided into three groups. Those with DM before the onset of AIP were labeled group A (n=35), those who developed DM and AIP simultaneously were labeled group B (n=58) and those who developed DM after steroid therapy for AIP were labeled group C (n=9). The characteristics of DM among the three groups were evaluated. RESULTS: No significant differences were noted in the age of DM onset among the three groups. However, the mean duration of DM was significantly longer in group A (8.7 years) than in groups B and C. AIP developed 6.8 years after DM onset in group A, whereas it developed 1.8 years after steroid therapy in group C. Group A had the highest rate (25.7%) of family members with a history of AIP. Levels of serum albumin, total cholesterol and triglyceride were significantly lower in group A. No correlations were found between glycated hemoglobin and benzoyl-tyrosyl para-aminobenzoic acid. Hypoglycemia was observed in 20% of patients under insulin therapy. Most of them were habitual drinkers and received no pancreatic enzymes. Group A showed a high prevalence of retinopathy, nephropathy and macrovascular disorders than group B. CONCLUSION: Aspects of AIP-associated pancreatic diabetes were clarified. AIP-associated DM must be controlled by a full assessment of the pancreatic endocrine and exocrine function.
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UR - http://www.scopus.com/inward/citedby.url?scp=79957611769&partnerID=8YFLogxK
U2 - 10.1111/j.1751-2980.2011.00498.x
DO - 10.1111/j.1751-2980.2011.00498.x
M3 - Article
C2 - 21615876
AN - SCOPUS:79957611769
VL - 12
SP - 210
EP - 216
JO - Journal of Digestive Diseases
JF - Journal of Digestive Diseases
SN - 1751-2972
IS - 3
ER -