Characteristics of patients with liver cancer in the BioBank Japan project

Biobank Japan Cooperative Hospital Group

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Liver cancer is the fifth cause of cancer-related deaths in Japan. The BioBank Japan (BBJ) project included 200,000 patients with 47 diseases and samples; their clinical information can be used for further studies. Methods: Patients diagnosed with liver cancer (n = 1733; 1316 men, 417 women) were included. Histology, patient characteristics, clinical characteristics, and causes of death were collected. Cumulative and relative survival rates for liver cancer were calculated. Results: Of the 1354 patients with available liver cancer histology, 91.9% had hepatocellular carcinoma (HCC). Compared with the National Health and Nutrition Examination Survey, greater proportions of the male patients in this cohort were daily alcohol consumers (26%), and a greater proportion of the menwas overweight/obesity (22%). Although Japan is the only Asian country with a predominance of hepatitis C virus (HCV)-related HCC, the prevalence of HCV infection (44%) was lower than that in a previous study. The 3-, 5-, and 10-year cumulative survival rates were 57%, 47%, and 25% in men, respectively, and 49%, 41%, and 27% in women, respectively. Conclusions: The present results provide an overview of the patients with liver cancer in the BBJ project. We are planning further analyses combined with various high-throughput 'omics' technologies.

Original languageEnglish
Pages (from-to)S43-S48
JournalJournal of epidemiology
Volume27
Issue number3
DOIs
Publication statusPublished - Jan 1 2017

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Liver Neoplasms
Japan
Hepacivirus
Hepatocellular Carcinoma
Histology
Survival Rate
Nutrition Surveys
Virus Diseases
Cause of Death
Obesity
Alcohols
Technology
Neoplasms

All Science Journal Classification (ASJC) codes

  • Epidemiology

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Characteristics of patients with liver cancer in the BioBank Japan project. / Biobank Japan Cooperative Hospital Group.

In: Journal of epidemiology, Vol. 27, No. 3, 01.01.2017, p. S43-S48.

Research output: Contribution to journalArticle

Biobank Japan Cooperative Hospital Group. / Characteristics of patients with liver cancer in the BioBank Japan project. In: Journal of epidemiology. 2017 ; Vol. 27, No. 3. pp. S43-S48.
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title = "Characteristics of patients with liver cancer in the BioBank Japan project",
abstract = "Background: Liver cancer is the fifth cause of cancer-related deaths in Japan. The BioBank Japan (BBJ) project included 200,000 patients with 47 diseases and samples; their clinical information can be used for further studies. Methods: Patients diagnosed with liver cancer (n = 1733; 1316 men, 417 women) were included. Histology, patient characteristics, clinical characteristics, and causes of death were collected. Cumulative and relative survival rates for liver cancer were calculated. Results: Of the 1354 patients with available liver cancer histology, 91.9{\%} had hepatocellular carcinoma (HCC). Compared with the National Health and Nutrition Examination Survey, greater proportions of the male patients in this cohort were daily alcohol consumers (26{\%}), and a greater proportion of the menwas overweight/obesity (22{\%}). Although Japan is the only Asian country with a predominance of hepatitis C virus (HCV)-related HCC, the prevalence of HCV infection (44{\%}) was lower than that in a previous study. The 3-, 5-, and 10-year cumulative survival rates were 57{\%}, 47{\%}, and 25{\%} in men, respectively, and 49{\%}, 41{\%}, and 27{\%} in women, respectively. Conclusions: The present results provide an overview of the patients with liver cancer in the BBJ project. We are planning further analyses combined with various high-throughput 'omics' technologies.",
author = "{Biobank Japan Cooperative Hospital Group} and Shigekazu Ukawa and Emiko Okada and Koshi Nakamura and Makoto Hirata and Akiko Nagai and Koichi Matsuda and Zentaro Yamagata and Yoichiro Kamatani and Toshiharu Ninomiya and Toshiharu Ninomiya and Kaori Muto and Michiaki Kubo and Yusuke Nakamura and Akiko Tamakoshi and Hiromasa Harada and Kiyoshi Kaneko and Shuichi Matsumoto and Masaki Shiono and Shiro Minami and Hiroshi Yoshida and Nobuhiko Taniai and Sumio Watanabe and Noriko Fujiwara and Atsuyuki Yamataka and Satoshi Asai and Mitsuhiko Moriyama and Yasuo Takahashi and Tomoaki Fujioka and Wataru Obara and Seijiro Mori and Hideki Ito and Satoshi Nagayama and Yoshio Miki and Akihide Masumoto and Akira Yamada and Yasuko Nishizawa and Ken Kodama and Shigeyuki Naka and Yoshihiro Endo and Yukihiro Koretsune and Eiji Mita and Kozo Morimoto",
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T1 - Characteristics of patients with liver cancer in the BioBank Japan project

AU - Biobank Japan Cooperative Hospital Group

AU - Ukawa, Shigekazu

AU - Okada, Emiko

AU - Nakamura, Koshi

AU - Hirata, Makoto

AU - Nagai, Akiko

AU - Matsuda, Koichi

AU - Yamagata, Zentaro

AU - Kamatani, Yoichiro

AU - Ninomiya, Toshiharu

AU - Ninomiya, Toshiharu

AU - Muto, Kaori

AU - Kubo, Michiaki

AU - Nakamura, Yusuke

AU - Tamakoshi, Akiko

AU - Harada, Hiromasa

AU - Kaneko, Kiyoshi

AU - Matsumoto, Shuichi

AU - Shiono, Masaki

AU - Minami, Shiro

AU - Yoshida, Hiroshi

AU - Taniai, Nobuhiko

AU - Watanabe, Sumio

AU - Fujiwara, Noriko

AU - Yamataka, Atsuyuki

AU - Asai, Satoshi

AU - Moriyama, Mitsuhiko

AU - Takahashi, Yasuo

AU - Fujioka, Tomoaki

AU - Obara, Wataru

AU - Mori, Seijiro

AU - Ito, Hideki

AU - Nagayama, Satoshi

AU - Miki, Yoshio

AU - Masumoto, Akihide

AU - Yamada, Akira

AU - Nishizawa, Yasuko

AU - Kodama, Ken

AU - Naka, Shigeyuki

AU - Endo, Yoshihiro

AU - Koretsune, Yukihiro

AU - Mita, Eiji

AU - Morimoto, Kozo

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Liver cancer is the fifth cause of cancer-related deaths in Japan. The BioBank Japan (BBJ) project included 200,000 patients with 47 diseases and samples; their clinical information can be used for further studies. Methods: Patients diagnosed with liver cancer (n = 1733; 1316 men, 417 women) were included. Histology, patient characteristics, clinical characteristics, and causes of death were collected. Cumulative and relative survival rates for liver cancer were calculated. Results: Of the 1354 patients with available liver cancer histology, 91.9% had hepatocellular carcinoma (HCC). Compared with the National Health and Nutrition Examination Survey, greater proportions of the male patients in this cohort were daily alcohol consumers (26%), and a greater proportion of the menwas overweight/obesity (22%). Although Japan is the only Asian country with a predominance of hepatitis C virus (HCV)-related HCC, the prevalence of HCV infection (44%) was lower than that in a previous study. The 3-, 5-, and 10-year cumulative survival rates were 57%, 47%, and 25% in men, respectively, and 49%, 41%, and 27% in women, respectively. Conclusions: The present results provide an overview of the patients with liver cancer in the BBJ project. We are planning further analyses combined with various high-throughput 'omics' technologies.

AB - Background: Liver cancer is the fifth cause of cancer-related deaths in Japan. The BioBank Japan (BBJ) project included 200,000 patients with 47 diseases and samples; their clinical information can be used for further studies. Methods: Patients diagnosed with liver cancer (n = 1733; 1316 men, 417 women) were included. Histology, patient characteristics, clinical characteristics, and causes of death were collected. Cumulative and relative survival rates for liver cancer were calculated. Results: Of the 1354 patients with available liver cancer histology, 91.9% had hepatocellular carcinoma (HCC). Compared with the National Health and Nutrition Examination Survey, greater proportions of the male patients in this cohort were daily alcohol consumers (26%), and a greater proportion of the menwas overweight/obesity (22%). Although Japan is the only Asian country with a predominance of hepatitis C virus (HCV)-related HCC, the prevalence of HCV infection (44%) was lower than that in a previous study. The 3-, 5-, and 10-year cumulative survival rates were 57%, 47%, and 25% in men, respectively, and 49%, 41%, and 27% in women, respectively. Conclusions: The present results provide an overview of the patients with liver cancer in the BBJ project. We are planning further analyses combined with various high-throughput 'omics' technologies.

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