Characteristics of printing company workers newly diagnosed with occupational cholangiocarcinoma

Shoji Kubo, Masahiko Kinoshita, Shigekazu Takemura, Shogo Tanaka, Hiroji Shinkawa, Takayoshi Nishioka, Genya Hamano, Tokuji Ito, Makoto Abue, Masaru Aoki, Kei Nakagawa, Michiaki Unno, Susumu Hijioka, Toshihisa Fujiyoshi, Yasuhiro Shimizu, Toru Mizuguchi, Ken Shirabe, Akihiro Nishie, Yoshinao Oda, Kenji TakenakaTomonari Kobarai, Terumasa Hisano, Akio Saiura, Hiroshi Numao, Mayura Toda, Yuko Kuwae, Yasuni Nakanuma, Ginji Endo

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Cholangiocarcinoma has been reported in workers exposed to chlorinated organic solvents and has consequently been classified as an occupational disease (occupational cholangiocarcinoma) by the Japanese Ministry of Health, Labour and Welfare. This study aimed to identify the characteristics of nine workers newly diagnosed with occupational cholangiocarcinoma. Methods: This study was a retrospective study conducted in 13 hospitals and three universities. Clinicopathological findings of nine occupational cholangiocarcinoma patients from seven printing companies in Japan were investigated and compared with 17 cholangiocarcinoma patients clustered in a single printing company in Osaka. Results: Patient age at diagnosis was 31-57 years. Patients were exposed to 1,2-dichloropropane and/or dichloromethane. Serum γ-glutamyl transpeptidase activity was elevated in all patients. Regional dilatation of the intrahepatic bile ducts without tumor-induced obstruction was observed in two patients. Four patients developed intrahepatic cholangiocarcinoma and five developed hilar cholangiocarcinoma. Biliary intraepithelial neoplasia and/or intraductal papillary neoplasm of the bile duct was observed in four patients with available operative or autopsy specimens. Conclusions: Most of these patients with occupational cholangiocarcinoma exhibited typical findings, including high serum γ-glutamyl transpeptidase activity, regional dilatation of the bile ducts, and precancerous lesions, similar to findings previously reported in 17 occupational cholangiocarcinoma patients in Osaka.

Original languageEnglish
Pages (from-to)809-817
Number of pages9
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume21
Issue number11
DOIs
Publication statusPublished - Nov 1 2014

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Printing
Cholangiocarcinoma
gamma-Glutamyltransferase
Dilatation
Klatskin Tumor
Bile Duct Neoplasms
Intrahepatic Bile Ducts
Occupational Diseases
Methylene Chloride
Bile Ducts
Serum
Autopsy
Neoplasms
Japan
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kubo, S., Kinoshita, M., Takemura, S., Tanaka, S., Shinkawa, H., Nishioka, T., ... Endo, G. (2014). Characteristics of printing company workers newly diagnosed with occupational cholangiocarcinoma. Journal of Hepato-Biliary-Pancreatic Sciences, 21(11), 809-817. https://doi.org/10.1002/jhbp.137

Characteristics of printing company workers newly diagnosed with occupational cholangiocarcinoma. / Kubo, Shoji; Kinoshita, Masahiko; Takemura, Shigekazu; Tanaka, Shogo; Shinkawa, Hiroji; Nishioka, Takayoshi; Hamano, Genya; Ito, Tokuji; Abue, Makoto; Aoki, Masaru; Nakagawa, Kei; Unno, Michiaki; Hijioka, Susumu; Fujiyoshi, Toshihisa; Shimizu, Yasuhiro; Mizuguchi, Toru; Shirabe, Ken; Nishie, Akihiro; Oda, Yoshinao; Takenaka, Kenji; Kobarai, Tomonari; Hisano, Terumasa; Saiura, Akio; Numao, Hiroshi; Toda, Mayura; Kuwae, Yuko; Nakanuma, Yasuni; Endo, Ginji.

In: Journal of Hepato-Biliary-Pancreatic Sciences, Vol. 21, No. 11, 01.11.2014, p. 809-817.

Research output: Contribution to journalArticle

Kubo, S, Kinoshita, M, Takemura, S, Tanaka, S, Shinkawa, H, Nishioka, T, Hamano, G, Ito, T, Abue, M, Aoki, M, Nakagawa, K, Unno, M, Hijioka, S, Fujiyoshi, T, Shimizu, Y, Mizuguchi, T, Shirabe, K, Nishie, A, Oda, Y, Takenaka, K, Kobarai, T, Hisano, T, Saiura, A, Numao, H, Toda, M, Kuwae, Y, Nakanuma, Y & Endo, G 2014, 'Characteristics of printing company workers newly diagnosed with occupational cholangiocarcinoma', Journal of Hepato-Biliary-Pancreatic Sciences, vol. 21, no. 11, pp. 809-817. https://doi.org/10.1002/jhbp.137
Kubo, Shoji ; Kinoshita, Masahiko ; Takemura, Shigekazu ; Tanaka, Shogo ; Shinkawa, Hiroji ; Nishioka, Takayoshi ; Hamano, Genya ; Ito, Tokuji ; Abue, Makoto ; Aoki, Masaru ; Nakagawa, Kei ; Unno, Michiaki ; Hijioka, Susumu ; Fujiyoshi, Toshihisa ; Shimizu, Yasuhiro ; Mizuguchi, Toru ; Shirabe, Ken ; Nishie, Akihiro ; Oda, Yoshinao ; Takenaka, Kenji ; Kobarai, Tomonari ; Hisano, Terumasa ; Saiura, Akio ; Numao, Hiroshi ; Toda, Mayura ; Kuwae, Yuko ; Nakanuma, Yasuni ; Endo, Ginji. / Characteristics of printing company workers newly diagnosed with occupational cholangiocarcinoma. In: Journal of Hepato-Biliary-Pancreatic Sciences. 2014 ; Vol. 21, No. 11. pp. 809-817.
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abstract = "Background: Cholangiocarcinoma has been reported in workers exposed to chlorinated organic solvents and has consequently been classified as an occupational disease (occupational cholangiocarcinoma) by the Japanese Ministry of Health, Labour and Welfare. This study aimed to identify the characteristics of nine workers newly diagnosed with occupational cholangiocarcinoma. Methods: This study was a retrospective study conducted in 13 hospitals and three universities. Clinicopathological findings of nine occupational cholangiocarcinoma patients from seven printing companies in Japan were investigated and compared with 17 cholangiocarcinoma patients clustered in a single printing company in Osaka. Results: Patient age at diagnosis was 31-57 years. Patients were exposed to 1,2-dichloropropane and/or dichloromethane. Serum γ-glutamyl transpeptidase activity was elevated in all patients. Regional dilatation of the intrahepatic bile ducts without tumor-induced obstruction was observed in two patients. Four patients developed intrahepatic cholangiocarcinoma and five developed hilar cholangiocarcinoma. Biliary intraepithelial neoplasia and/or intraductal papillary neoplasm of the bile duct was observed in four patients with available operative or autopsy specimens. Conclusions: Most of these patients with occupational cholangiocarcinoma exhibited typical findings, including high serum γ-glutamyl transpeptidase activity, regional dilatation of the bile ducts, and precancerous lesions, similar to findings previously reported in 17 occupational cholangiocarcinoma patients in Osaka.",
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T1 - Characteristics of printing company workers newly diagnosed with occupational cholangiocarcinoma

AU - Kubo, Shoji

AU - Kinoshita, Masahiko

AU - Takemura, Shigekazu

AU - Tanaka, Shogo

AU - Shinkawa, Hiroji

AU - Nishioka, Takayoshi

AU - Hamano, Genya

AU - Ito, Tokuji

AU - Abue, Makoto

AU - Aoki, Masaru

AU - Nakagawa, Kei

AU - Unno, Michiaki

AU - Hijioka, Susumu

AU - Fujiyoshi, Toshihisa

AU - Shimizu, Yasuhiro

AU - Mizuguchi, Toru

AU - Shirabe, Ken

AU - Nishie, Akihiro

AU - Oda, Yoshinao

AU - Takenaka, Kenji

AU - Kobarai, Tomonari

AU - Hisano, Terumasa

AU - Saiura, Akio

AU - Numao, Hiroshi

AU - Toda, Mayura

AU - Kuwae, Yuko

AU - Nakanuma, Yasuni

AU - Endo, Ginji

PY - 2014/11/1

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N2 - Background: Cholangiocarcinoma has been reported in workers exposed to chlorinated organic solvents and has consequently been classified as an occupational disease (occupational cholangiocarcinoma) by the Japanese Ministry of Health, Labour and Welfare. This study aimed to identify the characteristics of nine workers newly diagnosed with occupational cholangiocarcinoma. Methods: This study was a retrospective study conducted in 13 hospitals and three universities. Clinicopathological findings of nine occupational cholangiocarcinoma patients from seven printing companies in Japan were investigated and compared with 17 cholangiocarcinoma patients clustered in a single printing company in Osaka. Results: Patient age at diagnosis was 31-57 years. Patients were exposed to 1,2-dichloropropane and/or dichloromethane. Serum γ-glutamyl transpeptidase activity was elevated in all patients. Regional dilatation of the intrahepatic bile ducts without tumor-induced obstruction was observed in two patients. Four patients developed intrahepatic cholangiocarcinoma and five developed hilar cholangiocarcinoma. Biliary intraepithelial neoplasia and/or intraductal papillary neoplasm of the bile duct was observed in four patients with available operative or autopsy specimens. Conclusions: Most of these patients with occupational cholangiocarcinoma exhibited typical findings, including high serum γ-glutamyl transpeptidase activity, regional dilatation of the bile ducts, and precancerous lesions, similar to findings previously reported in 17 occupational cholangiocarcinoma patients in Osaka.

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