TY - JOUR
T1 - Characteristics of tobacco-related lung diseases in Fukuoka Prefecture, Japan
T2 - A prospective, multi-institutional, observational study
AU - Fukuoka tobacco-related lung disease (FOLD) registry study group, Fukuoka, Japan
AU - Ogata-Suetsugu, Saiko
AU - Hamada, Naoki
AU - Tsuda, Toru
AU - Takata, Shohei
AU - Kitasato, Yasuhiko
AU - Inoue, Naoyuki
AU - Nagata, Nobuhiko
AU - Yatera, Kazuhiro
AU - Mukae, Hiroshi
AU - Yoshii, Chiharu
AU - Hoshino, Tomoaki
AU - Fujita, Masaki
AU - Watanabe, Kentaro
AU - Tokunaga, Shoji
AU - Nakanishi, Yoichi
N1 - Funding Information:
This study was supported by a grant from the Ministry of Education, Culture, Sports, Science and Technology : the broad-area, network-based project to drive clinical research at Kyushu University Hospital, and partly supported by a grant to the Diffuse Lung Diseases Research Group from the Ministry of Health, Labor and Welfare , Japan. We would like to thank Clinical Research Support Center Kyushu for their official work regarding this study, S. Tamura for technical assistance, and Enago ( www.enago.jp ) for the English language review.
Publisher Copyright:
© 2019 The Japanese Respiratory Society
PY - 2020/1
Y1 - 2020/1
N2 - Background: Tobacco smoking causes a variety of smoking-related diseases, death, and economic damage. Despite targeted anti-smoking campaigns, tobacco-related deaths are expected to increase in Japan. We investigated the current state of non-cancerous lung diseases such as idiopathic interstitial pneumonias (IIPs), chronic obstructive pulmonary disease (COPD), and combined pulmonary fibrosis and emphysema (CPFE), which are known to be highly related to tobacco smoking. Methods: This prospective multi-institutional observational study involved 29 major hospitals within the Fukuoka Prefecture area (Fukuoka tobacco-related lung disease registry study group). Patients diagnosed with IIPs, including CPFE and COPD, registered from September 1, 2013 to April 30, 2016 were included. Clinical background information, laboratory and pulmonary function test results, findings of imaging tests, including chest radiography and chest computed tomography, and DNA isolated from peripheral blood were collected from each patient. Follow-up surveillance involved collection of data regarding the exacerbation of disease and death until 5 years of registration. In the present study, we report the baseline characteristics of the patients registered in this surveillance study. Results: Overall, 1016 patients (524 with IIPs, including 145 CPFE and 492 with COPD) were enrolled. Among the patients with COPD, 96.8% were current or former smokers. Among the patients with IIPs, 69.9% were current or former smokers. Conclusion: This study revealed the current status of lung diseases potentially related to tobacco smoking in Fukuoka Prefecture. Both COPD and CPFE were highly related to tobacco smoking, whereas 30% of patients with IIPs had never smoked.
AB - Background: Tobacco smoking causes a variety of smoking-related diseases, death, and economic damage. Despite targeted anti-smoking campaigns, tobacco-related deaths are expected to increase in Japan. We investigated the current state of non-cancerous lung diseases such as idiopathic interstitial pneumonias (IIPs), chronic obstructive pulmonary disease (COPD), and combined pulmonary fibrosis and emphysema (CPFE), which are known to be highly related to tobacco smoking. Methods: This prospective multi-institutional observational study involved 29 major hospitals within the Fukuoka Prefecture area (Fukuoka tobacco-related lung disease registry study group). Patients diagnosed with IIPs, including CPFE and COPD, registered from September 1, 2013 to April 30, 2016 were included. Clinical background information, laboratory and pulmonary function test results, findings of imaging tests, including chest radiography and chest computed tomography, and DNA isolated from peripheral blood were collected from each patient. Follow-up surveillance involved collection of data regarding the exacerbation of disease and death until 5 years of registration. In the present study, we report the baseline characteristics of the patients registered in this surveillance study. Results: Overall, 1016 patients (524 with IIPs, including 145 CPFE and 492 with COPD) were enrolled. Among the patients with COPD, 96.8% were current or former smokers. Among the patients with IIPs, 69.9% were current or former smokers. Conclusion: This study revealed the current status of lung diseases potentially related to tobacco smoking in Fukuoka Prefecture. Both COPD and CPFE were highly related to tobacco smoking, whereas 30% of patients with IIPs had never smoked.
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U2 - 10.1016/j.resinv.2019.10.002
DO - 10.1016/j.resinv.2019.10.002
M3 - Article
C2 - 31727581
AN - SCOPUS:85075377076
SN - 2212-5345
VL - 58
SP - 74
EP - 80
JO - Respiratory Investigation
JF - Respiratory Investigation
IS - 1
ER -
