Characteristics of whispering gallery mode in microsphere covered antigen-antibody layer at attenuated-total-reflection configuration

Takeshi Tajiri, Shuzo Matsumoto, Toshihiko Imato, Toshihiro Okamoto, Masanobu Haraguchi

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)

Abstract

Microresonators have attracted attention over the past few years because label-free optical biosensors base on them have potential in pathogen virus and healthcare and pharmaceuticals and the food industry. Whispering gallery mode (WGM) microresonators have advantages of an ultra-high Qfactors and a mass production capability of a sensor chip. This work presents a variation of WGM spectra depending on each antibody and antigen bound to a polystyrene microsphere, which allowed us to evaluate optically the thickness and the refractive index of the antigen antibody layer from a shift of the WGM spectra peak. Furthermore, the split variation of the WGM spectra peak by the adsorption of the antigen antibody was evaluated by polarization and the excitation position. The split variation of the scattered light peak depended on the direction circumnavigating microsphere.

Original languageEnglish
Article number6985080
Pages (from-to)641-644
Number of pages4
JournalProceedings of IEEE Sensors
Volume2014-December
Issue numberDecember
DOIs
Publication statusPublished - Jan 1 2014
Event13th IEEE SENSORS Conference, SENSORS 2014 - Valencia, Spain
Duration: Nov 2 2014Nov 5 2014

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering

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