Characterization of blasts from a patient with eosinophilic blast crisis of chronic myelogenous leukaemia

Toshihiro Miyamoto, Koji Nagafuji, Mine Harada, Kazuo Yamasaki, Tsunefumi Shibuya, Hiromi Iwasaki, Koichi Akashi, Shin‐ichi ‐i Mizuno, Tetsuya Eto, Katsuto Takenaka, Hisashi Gondo, Takashi Okamura, Yoshiyuki Niho

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Abstract

Summary. We investigated the biological characteristics of ‘eosinophilic’ leukaemic blasts from a patient with eosinophilic blast crisis of chronic myelogenous leukaemia (CML). Southern blot analysis of the bcr gene demonstrated the identical single rearranged band in both the leukaemic blasts and mature eosinophils. IL‐3, IL‐5 and GM‐CSF significantly enhanced proliferation and differentiation of these leukaemic blasts, and only eosinophils were generated from in vitro cultures. Those eosinophils expressed the B3A2 chimaeric messenger RNA seen in the leukaemic blasts. These observations indicate that eosinophil progenitors may be involved in the development of eosinophilic blast crisis of CML and that IL‐3, IL‐5 and GM‐CSF act on the leukaemic eosinophil progenitors. 1995 Blackwell Publishing Ltd

Original languageEnglish
Pages (from-to)207-210
Number of pages4
JournalBritish Journal of Haematology
Volume89
Issue number1
DOIs
Publication statusPublished - Jan 1995

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All Science Journal Classification (ASJC) codes

  • Hematology

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