TY - JOUR
T1 - Characterization of blasts from a patient with eosinophilic blast crisis of chronic myelogenous leukaemia
AU - Miyamoto, Toshihiro
AU - Nagafuji, Koji
AU - Harada, Mine
AU - Yamasaki, Kazuo
AU - Shibuya, Tsunefumi
AU - Iwasaki, Hiromi
AU - Akashi, Koichi
AU - Mizuno, Shin‐ichi ‐i
AU - Eto, Tetsuya
AU - Takenaka, Katsuto
AU - Gondo, Hisashi
AU - Okamura, Takashi
AU - Niho, Yoshiyuki
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1995/1
Y1 - 1995/1
N2 - Summary. We investigated the biological characteristics of ‘eosinophilic’ leukaemic blasts from a patient with eosinophilic blast crisis of chronic myelogenous leukaemia (CML). Southern blot analysis of the bcr gene demonstrated the identical single rearranged band in both the leukaemic blasts and mature eosinophils. IL‐3, IL‐5 and GM‐CSF significantly enhanced proliferation and differentiation of these leukaemic blasts, and only eosinophils were generated from in vitro cultures. Those eosinophils expressed the B3A2 chimaeric messenger RNA seen in the leukaemic blasts. These observations indicate that eosinophil progenitors may be involved in the development of eosinophilic blast crisis of CML and that IL‐3, IL‐5 and GM‐CSF act on the leukaemic eosinophil progenitors. 1995 Blackwell Publishing Ltd
AB - Summary. We investigated the biological characteristics of ‘eosinophilic’ leukaemic blasts from a patient with eosinophilic blast crisis of chronic myelogenous leukaemia (CML). Southern blot analysis of the bcr gene demonstrated the identical single rearranged band in both the leukaemic blasts and mature eosinophils. IL‐3, IL‐5 and GM‐CSF significantly enhanced proliferation and differentiation of these leukaemic blasts, and only eosinophils were generated from in vitro cultures. Those eosinophils expressed the B3A2 chimaeric messenger RNA seen in the leukaemic blasts. These observations indicate that eosinophil progenitors may be involved in the development of eosinophilic blast crisis of CML and that IL‐3, IL‐5 and GM‐CSF act on the leukaemic eosinophil progenitors. 1995 Blackwell Publishing Ltd
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U2 - 10.1111/j.1365-2141.1995.tb08933.x
DO - 10.1111/j.1365-2141.1995.tb08933.x
M3 - Article
C2 - 7833266
AN - SCOPUS:0028964236
SN - 0007-1048
VL - 89
SP - 207
EP - 210
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 1
ER -