Characterization of duplicated zebrafish cyp19 genes

Evelyn Feng Lin Chiang, Yi Lin Yan, Sok Keng Tong, Pei Hung Hsiao, Yann Guiguen, John Postlethwait, Bon Chu Chung

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

The zebrafish has recently been developed as a good genetic model system. We report here the use of zebrafish to study the regulation of estrogen biosynthesis. The CYP19 gene encodes cytochrome P450 aromatase, which catalyzes the synthesis of estrogens. Two cyp19 genes, termed cyp19a and cyp19b, have been isolated from zebrafish. Sequence comparison shows that Cyp19a and Cyp19b belong to two separate Cyp19 subfamilies. The cyp19a gene is expressed in the ovary, whereas cyp19b is expressed in the brain. The cyp19a and cyp19b genes are located on zebrafish chromosomes LG 18 and 25, respectively. Our data indicate that these gene loci arose through an ancient chromosomal duplication event. The expression of duplicated genes in distinct tissues may have evolutionary significance.

Original languageEnglish
Pages (from-to)709-714
Number of pages6
JournalJournal of Experimental Zoology
Volume290
Issue number7
DOIs
Publication statusPublished - Dec 1 2001

Fingerprint

Danio rerio
genes
estrogens
cytochrome P-450
biosynthesis
chromosomes
brain
gene expression
loci
synthesis

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology

Cite this

Chiang, E. F. L., Yan, Y. L., Tong, S. K., Hsiao, P. H., Guiguen, Y., Postlethwait, J., & Chung, B. C. (2001). Characterization of duplicated zebrafish cyp19 genes. Journal of Experimental Zoology, 290(7), 709-714. https://doi.org/10.1002/jez.1121

Characterization of duplicated zebrafish cyp19 genes. / Chiang, Evelyn Feng Lin; Yan, Yi Lin; Tong, Sok Keng; Hsiao, Pei Hung; Guiguen, Yann; Postlethwait, John; Chung, Bon Chu.

In: Journal of Experimental Zoology, Vol. 290, No. 7, 01.12.2001, p. 709-714.

Research output: Contribution to journalArticle

Chiang, EFL, Yan, YL, Tong, SK, Hsiao, PH, Guiguen, Y, Postlethwait, J & Chung, BC 2001, 'Characterization of duplicated zebrafish cyp19 genes', Journal of Experimental Zoology, vol. 290, no. 7, pp. 709-714. https://doi.org/10.1002/jez.1121
Chiang EFL, Yan YL, Tong SK, Hsiao PH, Guiguen Y, Postlethwait J et al. Characterization of duplicated zebrafish cyp19 genes. Journal of Experimental Zoology. 2001 Dec 1;290(7):709-714. https://doi.org/10.1002/jez.1121
Chiang, Evelyn Feng Lin ; Yan, Yi Lin ; Tong, Sok Keng ; Hsiao, Pei Hung ; Guiguen, Yann ; Postlethwait, John ; Chung, Bon Chu. / Characterization of duplicated zebrafish cyp19 genes. In: Journal of Experimental Zoology. 2001 ; Vol. 290, No. 7. pp. 709-714.
@article{966dfb6505314d269c769d3390175c08,
title = "Characterization of duplicated zebrafish cyp19 genes",
abstract = "The zebrafish has recently been developed as a good genetic model system. We report here the use of zebrafish to study the regulation of estrogen biosynthesis. The CYP19 gene encodes cytochrome P450 aromatase, which catalyzes the synthesis of estrogens. Two cyp19 genes, termed cyp19a and cyp19b, have been isolated from zebrafish. Sequence comparison shows that Cyp19a and Cyp19b belong to two separate Cyp19 subfamilies. The cyp19a gene is expressed in the ovary, whereas cyp19b is expressed in the brain. The cyp19a and cyp19b genes are located on zebrafish chromosomes LG 18 and 25, respectively. Our data indicate that these gene loci arose through an ancient chromosomal duplication event. The expression of duplicated genes in distinct tissues may have evolutionary significance.",
author = "Chiang, {Evelyn Feng Lin} and Yan, {Yi Lin} and Tong, {Sok Keng} and Hsiao, {Pei Hung} and Yann Guiguen and John Postlethwait and Chung, {Bon Chu}",
year = "2001",
month = "12",
day = "1",
doi = "10.1002/jez.1121",
language = "English",
volume = "290",
pages = "709--714",
journal = "Journal of Experimental Zoology",
issn = "0022-104X",
publisher = "John Wiley and Sons Inc.",
number = "7",

}

TY - JOUR

T1 - Characterization of duplicated zebrafish cyp19 genes

AU - Chiang, Evelyn Feng Lin

AU - Yan, Yi Lin

AU - Tong, Sok Keng

AU - Hsiao, Pei Hung

AU - Guiguen, Yann

AU - Postlethwait, John

AU - Chung, Bon Chu

PY - 2001/12/1

Y1 - 2001/12/1

N2 - The zebrafish has recently been developed as a good genetic model system. We report here the use of zebrafish to study the regulation of estrogen biosynthesis. The CYP19 gene encodes cytochrome P450 aromatase, which catalyzes the synthesis of estrogens. Two cyp19 genes, termed cyp19a and cyp19b, have been isolated from zebrafish. Sequence comparison shows that Cyp19a and Cyp19b belong to two separate Cyp19 subfamilies. The cyp19a gene is expressed in the ovary, whereas cyp19b is expressed in the brain. The cyp19a and cyp19b genes are located on zebrafish chromosomes LG 18 and 25, respectively. Our data indicate that these gene loci arose through an ancient chromosomal duplication event. The expression of duplicated genes in distinct tissues may have evolutionary significance.

AB - The zebrafish has recently been developed as a good genetic model system. We report here the use of zebrafish to study the regulation of estrogen biosynthesis. The CYP19 gene encodes cytochrome P450 aromatase, which catalyzes the synthesis of estrogens. Two cyp19 genes, termed cyp19a and cyp19b, have been isolated from zebrafish. Sequence comparison shows that Cyp19a and Cyp19b belong to two separate Cyp19 subfamilies. The cyp19a gene is expressed in the ovary, whereas cyp19b is expressed in the brain. The cyp19a and cyp19b genes are located on zebrafish chromosomes LG 18 and 25, respectively. Our data indicate that these gene loci arose through an ancient chromosomal duplication event. The expression of duplicated genes in distinct tissues may have evolutionary significance.

UR - http://www.scopus.com/inward/record.url?scp=0035575613&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035575613&partnerID=8YFLogxK

U2 - 10.1002/jez.1121

DO - 10.1002/jez.1121

M3 - Article

C2 - 11748619

AN - SCOPUS:0035575613

VL - 290

SP - 709

EP - 714

JO - Journal of Experimental Zoology

JF - Journal of Experimental Zoology

SN - 0022-104X

IS - 7

ER -