Characterization of galectin-1-positive cells in the mouse hippocampus

Kosuke Kajitani, Yuko Kobayakawa, Hiroko Nomaru, Toshihiko Kadoya, Hidenori Horie, Yusaku Nakabeppu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Galectin-1 (gal-1) is one of several well-studied proteins from the galectin families. It is a 14.5 kDa glycoprotein with a single carbohydrate-binding domain. To examine the distribution and properties of gal-1 in the mouse hippocampus, we performed immunohistochemistry using an anti-gal-1 antibody. We found that most gal-1-positive cells showed both NeuN and β-tubulin III (Tuj-1) immunoreactivity (NeuN: 93%, β-tubulin III: 88%). Furthermore, we clarified that 77% of gal-1-positive cells expressed somatostatin, 79% of gal-1-positive cells expressed GAD67, 34% of gal-1-positive cells expressed parvalbumin, 5% of gal-1-positive cells expressed calretinin, 2% of gal-1-positive cells expressed calbindin, and 31% of gal-1-positive cells expressed neuropeptide Y in the mouse hippocampus. These results indicate that gal-1 is expressed in interneurons that also express β-tubulin III and gal-1 may be a novel marker for interneuron subpopulations in the hippocampus.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalNeuroReport
Volume25
Issue number3
DOIs
Publication statusPublished - Feb 12 2014

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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