Characterization of leukaemic basophil progenitors from chronic myelogenous leukaemia

Takanori Teshima, Seiji Kondo, Mine Harada, Tsunefumi Shibuya, Takashi Okamura, Yuichi Tamari, Nobuhiro Kimura, Koichi Akashi, Seiichi Okamura, Yoshiyuki Niho

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Summary We describe the unique characteristics of leukaemic basophils from a patient with chronic myelogenous leukaemia (CML). The leukaemic cells were immature basophil‐like blasts and expressed CD4, CD7 and HLA‐DR in addition to CD13 and CD33. Both immunoglobulin and T cell receptor genes were retained in germline configurations. Interleukin‐1 (IL‐1) or granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) as well as IL‐3 or IL‐4 enhanced the proliferation and differentiation of leukaemic cells and only basophils were generated from in vitro culture. These results suggest that basophil progenitors expressing CD4, CD7 and HLA‐DR may be involved in the development of basophilic crisis of CML and that both IL‐1 and GM‐CSF may act on basophil progenitors as well as IL‐3 or IL‐4.

Original languageEnglish
Pages (from-to)55-59
Number of pages5
JournalBritish Journal of Haematology
Volume78
Issue number1
DOIs
Publication statusPublished - Jan 1 1991

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Basophils
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Interleukin-4
T-Cell Receptor Genes
Immunoglobulins
Cell Differentiation

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Teshima, T., Kondo, S., Harada, M., Shibuya, T., Okamura, T., Tamari, Y., ... Niho, Y. (1991). Characterization of leukaemic basophil progenitors from chronic myelogenous leukaemia. British Journal of Haematology, 78(1), 55-59. https://doi.org/10.1111/j.1365-2141.1991.tb04382.x

Characterization of leukaemic basophil progenitors from chronic myelogenous leukaemia. / Teshima, Takanori; Kondo, Seiji; Harada, Mine; Shibuya, Tsunefumi; Okamura, Takashi; Tamari, Yuichi; Kimura, Nobuhiro; Akashi, Koichi; Okamura, Seiichi; Niho, Yoshiyuki.

In: British Journal of Haematology, Vol. 78, No. 1, 01.01.1991, p. 55-59.

Research output: Contribution to journalArticle

Teshima, T, Kondo, S, Harada, M, Shibuya, T, Okamura, T, Tamari, Y, Kimura, N, Akashi, K, Okamura, S & Niho, Y 1991, 'Characterization of leukaemic basophil progenitors from chronic myelogenous leukaemia', British Journal of Haematology, vol. 78, no. 1, pp. 55-59. https://doi.org/10.1111/j.1365-2141.1991.tb04382.x
Teshima, Takanori ; Kondo, Seiji ; Harada, Mine ; Shibuya, Tsunefumi ; Okamura, Takashi ; Tamari, Yuichi ; Kimura, Nobuhiro ; Akashi, Koichi ; Okamura, Seiichi ; Niho, Yoshiyuki. / Characterization of leukaemic basophil progenitors from chronic myelogenous leukaemia. In: British Journal of Haematology. 1991 ; Vol. 78, No. 1. pp. 55-59.
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