Characterization of nanoparticle permeability on a membrane-integrated microfluidic device

N. Sasaki, M. Tatanou, Y. Anraku, A. Kishimura, K. Kataoka, K. Sato

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

We present a microfluidic platform to characterize nanoparticle permeability, which determines the efficiency of nanoparticle-based drug delivery to tumors. We integrated porous membranes that mimic tumor vascular walls into microfluidic devices. Permeation of the nanoparticles through the membranes was studied under control of transmembrane flow, which corresponds to outward flow from blood vessels to tumors in vivo. The obtained results agreed with a theoretical model considering the effect of particle/pore size ratio on the permeation. These results indicate that the device can be a simple model to estimate the permeability of the nanoparticles.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages1818-1820
Number of pages3
ISBN (Print)9781632666246
Publication statusPublished - Jan 1 2013
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: Oct 27 2013Oct 31 2013

Publication series

Name17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Volume3

Other

Other17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
CountryGermany
CityFreiburg
Period10/27/1310/31/13

All Science Journal Classification (ASJC) codes

  • Bioengineering

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