TY - GEN
T1 - Characterization of nanoparticle permeability on a membrane-integrated microfluidic device
AU - Sasaki, N.
AU - Tatanou, M.
AU - Anraku, Y.
AU - Kishimura, A.
AU - Kataoka, K.
AU - Sato, K.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - We present a microfluidic platform to characterize nanoparticle permeability, which determines the efficiency of nanoparticle-based drug delivery to tumors. We integrated porous membranes that mimic tumor vascular walls into microfluidic devices. Permeation of the nanoparticles through the membranes was studied under control of transmembrane flow, which corresponds to outward flow from blood vessels to tumors in vivo. The obtained results agreed with a theoretical model considering the effect of particle/pore size ratio on the permeation. These results indicate that the device can be a simple model to estimate the permeability of the nanoparticles.
AB - We present a microfluidic platform to characterize nanoparticle permeability, which determines the efficiency of nanoparticle-based drug delivery to tumors. We integrated porous membranes that mimic tumor vascular walls into microfluidic devices. Permeation of the nanoparticles through the membranes was studied under control of transmembrane flow, which corresponds to outward flow from blood vessels to tumors in vivo. The obtained results agreed with a theoretical model considering the effect of particle/pore size ratio on the permeation. These results indicate that the device can be a simple model to estimate the permeability of the nanoparticles.
UR - http://www.scopus.com/inward/record.url?scp=84907358924&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907358924&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84907358924
SN - 9781632666246
T3 - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
SP - 1818
EP - 1820
BT - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PB - Chemical and Biological Microsystems Society
T2 - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Y2 - 27 October 2013 through 31 October 2013
ER -