Characterization of natural killer cells in tamarins: A technical basis for studies of innate immunity

Tomoyuki Yoshida, Akatsuki Saito, Yuki Iwasaki, Sayuki Iijima, Terue Kurosawa, Yuko Katakai, Yasuhiro Yasutomi, Keith A. Reimann, Toshiyuki Hayakawa, Hirofumi Akari

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Natural killer (NK) cells are capable of regulating viral infection without major histocompatibility complex restriction. Hepatitis C is caused by chronic infection with hepatitis C virus (HCV), and impaired activity of NK cells may contribute to the control of the disease progression, although the involvement of NK cells in vivo remains to be proven. GB virus B (GBV-B), which is genetically most closely related to HCV, induces acute and chronic hepatitis upon experimental infection of tamarins. This non-human primate model seems likely to be useful for unveiling the roles of NK cells in vivo. Here we characterized the biological phenotypes of NK cells in tamarins and found that depletion of the CD16+ subset in vivo by administration of a monoclonal antibody significantly reduced the number and activity of NK cells.

Original languageEnglish
JournalFrontiers in Microbiology
Volume1
Issue numberDEC
DOIs
Publication statusPublished - Jan 1 2010
Externally publishedYes

Fingerprint

Innate Immunity
Natural Killer Cells
Hepacivirus
GB virus B
Virus Diseases
Chronic Hepatitis
Hepatitis C
Infection
Major Histocompatibility Complex
Primates
Disease Progression
Monoclonal Antibodies
Phenotype

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)

Cite this

Characterization of natural killer cells in tamarins : A technical basis for studies of innate immunity. / Yoshida, Tomoyuki; Saito, Akatsuki; Iwasaki, Yuki; Iijima, Sayuki; Kurosawa, Terue; Katakai, Yuko; Yasutomi, Yasuhiro; Reimann, Keith A.; Hayakawa, Toshiyuki; Akari, Hirofumi.

In: Frontiers in Microbiology, Vol. 1, No. DEC, 01.01.2010.

Research output: Contribution to journalArticle

Yoshida, T, Saito, A, Iwasaki, Y, Iijima, S, Kurosawa, T, Katakai, Y, Yasutomi, Y, Reimann, KA, Hayakawa, T & Akari, H 2010, 'Characterization of natural killer cells in tamarins: A technical basis for studies of innate immunity', Frontiers in Microbiology, vol. 1, no. DEC. https://doi.org/10.3389/fmicb.2010.00128
Yoshida, Tomoyuki ; Saito, Akatsuki ; Iwasaki, Yuki ; Iijima, Sayuki ; Kurosawa, Terue ; Katakai, Yuko ; Yasutomi, Yasuhiro ; Reimann, Keith A. ; Hayakawa, Toshiyuki ; Akari, Hirofumi. / Characterization of natural killer cells in tamarins : A technical basis for studies of innate immunity. In: Frontiers in Microbiology. 2010 ; Vol. 1, No. DEC.
@article{92cec36e421a4e988f4f8d38255434b4,
title = "Characterization of natural killer cells in tamarins: A technical basis for studies of innate immunity",
abstract = "Natural killer (NK) cells are capable of regulating viral infection without major histocompatibility complex restriction. Hepatitis C is caused by chronic infection with hepatitis C virus (HCV), and impaired activity of NK cells may contribute to the control of the disease progression, although the involvement of NK cells in vivo remains to be proven. GB virus B (GBV-B), which is genetically most closely related to HCV, induces acute and chronic hepatitis upon experimental infection of tamarins. This non-human primate model seems likely to be useful for unveiling the roles of NK cells in vivo. Here we characterized the biological phenotypes of NK cells in tamarins and found that depletion of the CD16+ subset in vivo by administration of a monoclonal antibody significantly reduced the number and activity of NK cells.",
author = "Tomoyuki Yoshida and Akatsuki Saito and Yuki Iwasaki and Sayuki Iijima and Terue Kurosawa and Yuko Katakai and Yasuhiro Yasutomi and Reimann, {Keith A.} and Toshiyuki Hayakawa and Hirofumi Akari",
year = "2010",
month = "1",
day = "1",
doi = "10.3389/fmicb.2010.00128",
language = "English",
volume = "1",
journal = "Frontiers in Microbiology",
issn = "1664-302X",
publisher = "Frontiers Media S. A.",
number = "DEC",

}

TY - JOUR

T1 - Characterization of natural killer cells in tamarins

T2 - A technical basis for studies of innate immunity

AU - Yoshida, Tomoyuki

AU - Saito, Akatsuki

AU - Iwasaki, Yuki

AU - Iijima, Sayuki

AU - Kurosawa, Terue

AU - Katakai, Yuko

AU - Yasutomi, Yasuhiro

AU - Reimann, Keith A.

AU - Hayakawa, Toshiyuki

AU - Akari, Hirofumi

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Natural killer (NK) cells are capable of regulating viral infection without major histocompatibility complex restriction. Hepatitis C is caused by chronic infection with hepatitis C virus (HCV), and impaired activity of NK cells may contribute to the control of the disease progression, although the involvement of NK cells in vivo remains to be proven. GB virus B (GBV-B), which is genetically most closely related to HCV, induces acute and chronic hepatitis upon experimental infection of tamarins. This non-human primate model seems likely to be useful for unveiling the roles of NK cells in vivo. Here we characterized the biological phenotypes of NK cells in tamarins and found that depletion of the CD16+ subset in vivo by administration of a monoclonal antibody significantly reduced the number and activity of NK cells.

AB - Natural killer (NK) cells are capable of regulating viral infection without major histocompatibility complex restriction. Hepatitis C is caused by chronic infection with hepatitis C virus (HCV), and impaired activity of NK cells may contribute to the control of the disease progression, although the involvement of NK cells in vivo remains to be proven. GB virus B (GBV-B), which is genetically most closely related to HCV, induces acute and chronic hepatitis upon experimental infection of tamarins. This non-human primate model seems likely to be useful for unveiling the roles of NK cells in vivo. Here we characterized the biological phenotypes of NK cells in tamarins and found that depletion of the CD16+ subset in vivo by administration of a monoclonal antibody significantly reduced the number and activity of NK cells.

UR - http://www.scopus.com/inward/record.url?scp=84856404315&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856404315&partnerID=8YFLogxK

U2 - 10.3389/fmicb.2010.00128

DO - 10.3389/fmicb.2010.00128

M3 - Article

C2 - 21713119

AN - SCOPUS:84856404315

VL - 1

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

SN - 1664-302X

IS - DEC

ER -