Characterizing vulnerable brain areas and circuits in mouse models of autism

Towards understanding pathogenesis and new therapeutic approaches

Kelvin Hui, Yuta Katayama, Keiichi Nakayama, Jun Nomura, Takeshi Sakurai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Recent human genetics studies have identified many genetic variants that may be responsible for autism spectrum disorder (ASD). ASD mouse models with genetic modifications mimicking these rare genetic variants have provided invaluable mechanistic insights into the disruption of various biological processes and brain areas/circuitry affected in ASD patients. In this review, we begin by reviewing several mouse models for ASD-associated copy number variations (CNVs) to illustrate how they have been employed to establish causal links between their behavioral phenotypes and the affected genes. We then focus on studies using one of the principal behavioral abnormalities associated with ASD, social behavior, to identify the molecular and circuit-level deficits involved. Finally, we end by discussing other mouse models designed to probe how the disruption of specific biological processes such as autophagy and neurogenesis may contribute to ASD pathogenesis. By achieving a greater understanding of the pathophysiology and pathogenic mechanisms involved in ASD and related disorders, novel therapeutic strategies may be devised for ASD patients in the near future.

Original languageEnglish
JournalNeuroscience and Biobehavioral Reviews
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Autistic Disorder
Brain
Biological Phenomena
Therapeutics
Autism Spectrum Disorder
Social Behavior
Genetic Models
Neurogenesis
Autophagy
Medical Genetics
Phenotype
Genes

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

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AU - Sakurai, Takeshi

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