Chemical Composition of the Essential Oil of Mastic Gum and their Antibacterial Activity Against Drug-Resistant Helicobacter pylori

Tomofumi Miyamoto, Tadayoshi Okimoto, Michihiko Kuwano

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Mastic gum is derived from the tree named Pistacia lentiscus that is grown only in Island Hios of Greek. Since Mastic was first reported to kill Helicobacter pylori (H. pylori) in 1998, there has been no further study to elucidate which component of mastic specifically shows the antimicrobial activity against H. pylori. In this study, we examined which component of mastic gum was responsible for anti-H. pylori activity. We prepared the essential oil of mastic gum and identified 20 constituents by GC–MS analysis. Ten standard components were assayed for anti-H. pylori activity, and it clarified that α-terpineol and (E)-methyl isoeugenol showed the anti-H. pylori activity against four different H. pylori strains that were established from patients with gastritis, gastric ulcer and gastric cancer. These components could be useful to overcome the drug-resistance H. pylori growth in stomach. Graphical Abstract: [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)227-231
Number of pages5
JournalNatural Products and Bioprospecting
Volume4
Issue number4
DOIs
Publication statusPublished - Aug 1 2014

All Science Journal Classification (ASJC) codes

  • Food Science
  • Plant Science
  • Biochemistry
  • Analytical Chemistry
  • Organic Chemistry
  • Pharmacology
  • Toxicology

Fingerprint Dive into the research topics of 'Chemical Composition of the Essential Oil of Mastic Gum and their Antibacterial Activity Against Drug-Resistant Helicobacter pylori'. Together they form a unique fingerprint.

  • Cite this