Chemistry of artificial nucleic acid and oligonucleotide therapeutics based on natural nucleic acids

Research output: Contribution to journalArticle

Abstract

Triplex DNA is a powerful tool for the genome researches and genome targeting technologies. However, there is an intrinsic limitation to form the stable triplex DNA at any duplex DNA sequence. Recently, we have developed the artificial nucleoside analogue to recognize the CG base pair that cannot be stabilized by natural nucleic acids. Interestingly, the artificial nucleic acid was designed on the basis of the natural T-CG triplex formation. Consequently, we succeeded in expanding the triplex DNA recognition code and achieved the inhibition of the gene expression by the novel antigene triplex forming oligonucleotides.

Original languageEnglish
Pages (from-to)482-485
Number of pages4
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume76
Issue number5
DOIs
Publication statusPublished - Jan 1 2018

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Oligonucleotides
Nucleic Acids
Genes
DNA sequences
Nucleosides
Gene expression
triplex DNA

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

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