Chemoenzymatically synthesized glycoconjugate polymers

Yoshiko Miura, Takayasu Ikeda, Kazukiyo Kobayashi

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Glycoconjugate polymers with poly(vinyl alcohol) (PVA) backbone were synthesized via a chemoenzymatic method. The sugar alcohols of maltose and lactose were submitted to transesterification in the presence of lipases. The esterification was achieved with high selectivity and yield, and the resulting maltitol and lactitol 6-vinyl sebacates were polymerized by a conventional radical initiator with hydrogen peroxide and ascorbic acid. The glycoconjugate polymers carrying α-glucose and β-galactose as recognition signals showed the biological activity such as lectin recognition abilities and hepatocyte adhension. The biodegradability of these polymers was modest but higher than PVA.

Original languageEnglish
Pages (from-to)410-415
Number of pages6
JournalBiomacromolecules
Volume4
Issue number2
DOIs
Publication statusPublished - Mar 1 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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