Chemoenzymatically synthesized glycoconjugate polymers

Yoshiko Miura; Takayasu Ikeda; Kazukiyo Kobayashi

doi:10.1021/bm025714b

Chemoenzymatically synthesized glycoconjugate polymers

Yoshiko Miura, Takayasu Ikeda, Kazukiyo Kobayashi

Research output: Contribution to journal › Article

77 Citations (Scopus)

Abstract

Glycoconjugate polymers with poly(vinyl alcohol) (PVA) backbone were synthesized via a chemoenzymatic method. The sugar alcohols of maltose and lactose were submitted to transesterification in the presence of lipases. The esterification was achieved with high selectivity and yield, and the resulting maltitol and lactitol 6-vinyl sebacates were polymerized by a conventional radical initiator with hydrogen peroxide and ascorbic acid. The glycoconjugate polymers carrying α-glucose and β-galactose as recognition signals showed the biological activity such as lectin recognition abilities and hepatocyte adhension. The biodegradability of these polymers was modest but higher than PVA.

Original language	English
Pages (from-to)	410-415
Number of pages	6
Journal	Biomacromolecules
Volume	4
Issue number	2
DOIs	https://doi.org/10.1021/bm025714b
Publication status	Published - Mar 1 2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

Access to Document

10.1021/bm025714b

Fingerprint Dive into the research topics of 'Chemoenzymatically synthesized glycoconjugate polymers'. Together they form a unique fingerprint.

Cite this

Miura, Y., Ikeda, T., & Kobayashi, K. (2003). Chemoenzymatically synthesized glycoconjugate polymers. Biomacromolecules, 4(2), 410-415. https://doi.org/10.1021/bm025714b

@article{777e0cc43b9240b6b0021c10ee1aeb64,

title = "Chemoenzymatically synthesized glycoconjugate polymers",

abstract = "Glycoconjugate polymers with poly(vinyl alcohol) (PVA) backbone were synthesized via a chemoenzymatic method. The sugar alcohols of maltose and lactose were submitted to transesterification in the presence of lipases. The esterification was achieved with high selectivity and yield, and the resulting maltitol and lactitol 6-vinyl sebacates were polymerized by a conventional radical initiator with hydrogen peroxide and ascorbic acid. The glycoconjugate polymers carrying α-glucose and β-galactose as recognition signals showed the biological activity such as lectin recognition abilities and hepatocyte adhension. The biodegradability of these polymers was modest but higher than PVA.",

author = "Yoshiko Miura and Takayasu Ikeda and Kazukiyo Kobayashi",

year = "2003",

month = mar,

day = "1",

doi = "10.1021/bm025714b",

language = "English",

volume = "4",

pages = "410--415",

journal = "Biomacromolecules",

issn = "1525-7797",

publisher = "American Chemical Society",

number = "2",

}

TY - JOUR

T1 - Chemoenzymatically synthesized glycoconjugate polymers

AU - Miura, Yoshiko

AU - Ikeda, Takayasu

AU - Kobayashi, Kazukiyo

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Glycoconjugate polymers with poly(vinyl alcohol) (PVA) backbone were synthesized via a chemoenzymatic method. The sugar alcohols of maltose and lactose were submitted to transesterification in the presence of lipases. The esterification was achieved with high selectivity and yield, and the resulting maltitol and lactitol 6-vinyl sebacates were polymerized by a conventional radical initiator with hydrogen peroxide and ascorbic acid. The glycoconjugate polymers carrying α-glucose and β-galactose as recognition signals showed the biological activity such as lectin recognition abilities and hepatocyte adhension. The biodegradability of these polymers was modest but higher than PVA.

AB - Glycoconjugate polymers with poly(vinyl alcohol) (PVA) backbone were synthesized via a chemoenzymatic method. The sugar alcohols of maltose and lactose were submitted to transesterification in the presence of lipases. The esterification was achieved with high selectivity and yield, and the resulting maltitol and lactitol 6-vinyl sebacates were polymerized by a conventional radical initiator with hydrogen peroxide and ascorbic acid. The glycoconjugate polymers carrying α-glucose and β-galactose as recognition signals showed the biological activity such as lectin recognition abilities and hepatocyte adhension. The biodegradability of these polymers was modest but higher than PVA.

UR - http://www.scopus.com/inward/record.url?scp=0038071802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038071802&partnerID=8YFLogxK

U2 - 10.1021/bm025714b

DO - 10.1021/bm025714b

M3 - Article

C2 - 12625739

AN - SCOPUS:0038071802

VL - 4

SP - 410

EP - 415

JO - Biomacromolecules

JF - Biomacromolecules

SN - 1525-7797

IS - 2

ER -