Chemoradiation therapy with or without salvage surgery for early squamous cell carcinoma of the hypopharynx

Katsumasa Nakamura, Yoshiyuki Shioyama, Tomonari Sasaki, Ohga Saiji, Madoka Saku, Yusuke Urashima, Tadamasa Yoshitake, Torahiko Nakashima, Yuichiro Kuratomi, Shizuo Komune, Hiromi Terashima, Hiroshi Honda

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose: Early squamous cell carcinoma of the hypopharynx is a rare clinical entity. Our objective was to analyze the outcome of patients with early hypopharyngeal cancer treated with curative radiotherapy or the combination of preoperative radiotherapy with surgery. Methods and Materials: Forty-three patients with Stage I-II hypopharyngeal cancer were initially treated with 30-40 Gy of irradiation with or without chemotherapy. Thirty-two patients (74.4%) who demonstrated a complete response continued to receive further radiotherapy, with a median total dose of 61.2 Gy. Eleven other patients (25.6%) received surgery. Results: Local control with laryngeal voice preservation was achieved in 8 (88.9%) of 9 patients with Stage I disease, and in 23 (67.6%) of 34 patients with Stage II disease. The overall and disease-specific 5-year survival rates for all patients were 70.4% and 89.5%, respectively. The disease-specific survival rates according to the T-category were 100% for patients with T1 disease and 87.2% for patients with T2 disease (p = 0.32). Twenty patients (46.5%) had synchronous or metachronous cancers. Four patients died of hypopharyngeal cancer, and 5 died of second-primary esophageal cancer. Conclusions: A majority of patients with early hypopharyngeal cancer was curable. However, second malignancies influenced the overall outcome of patients with early hypopharyngeal cancer.

Original languageEnglish
Pages (from-to)680-683
Number of pages4
JournalInternational Journal of Radiation Oncology Biology Physics
Volume62
Issue number3
DOIs
Publication statusPublished - Jul 1 2005

Fingerprint

Hypopharynx
surgery
Squamous Cell Carcinoma
therapy
cancer
Hypopharyngeal Neoplasms
Therapeutics
radiation therapy
Radiotherapy
Second Primary Neoplasms
Survival Rate
chemotherapy
Esophageal Neoplasms

All Science Journal Classification (ASJC) codes

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Chemoradiation therapy with or without salvage surgery for early squamous cell carcinoma of the hypopharynx. / Nakamura, Katsumasa; Shioyama, Yoshiyuki; Sasaki, Tomonari; Saiji, Ohga; Saku, Madoka; Urashima, Yusuke; Yoshitake, Tadamasa; Nakashima, Torahiko; Kuratomi, Yuichiro; Komune, Shizuo; Terashima, Hiromi; Honda, Hiroshi.

In: International Journal of Radiation Oncology Biology Physics, Vol. 62, No. 3, 01.07.2005, p. 680-683.

Research output: Contribution to journalArticle

Nakamura, Katsumasa ; Shioyama, Yoshiyuki ; Sasaki, Tomonari ; Saiji, Ohga ; Saku, Madoka ; Urashima, Yusuke ; Yoshitake, Tadamasa ; Nakashima, Torahiko ; Kuratomi, Yuichiro ; Komune, Shizuo ; Terashima, Hiromi ; Honda, Hiroshi. / Chemoradiation therapy with or without salvage surgery for early squamous cell carcinoma of the hypopharynx. In: International Journal of Radiation Oncology Biology Physics. 2005 ; Vol. 62, No. 3. pp. 680-683.
@article{e4702e0c6c3048a699499acb8ea31e2b,
title = "Chemoradiation therapy with or without salvage surgery for early squamous cell carcinoma of the hypopharynx",
abstract = "Purpose: Early squamous cell carcinoma of the hypopharynx is a rare clinical entity. Our objective was to analyze the outcome of patients with early hypopharyngeal cancer treated with curative radiotherapy or the combination of preoperative radiotherapy with surgery. Methods and Materials: Forty-three patients with Stage I-II hypopharyngeal cancer were initially treated with 30-40 Gy of irradiation with or without chemotherapy. Thirty-two patients (74.4{\%}) who demonstrated a complete response continued to receive further radiotherapy, with a median total dose of 61.2 Gy. Eleven other patients (25.6{\%}) received surgery. Results: Local control with laryngeal voice preservation was achieved in 8 (88.9{\%}) of 9 patients with Stage I disease, and in 23 (67.6{\%}) of 34 patients with Stage II disease. The overall and disease-specific 5-year survival rates for all patients were 70.4{\%} and 89.5{\%}, respectively. The disease-specific survival rates according to the T-category were 100{\%} for patients with T1 disease and 87.2{\%} for patients with T2 disease (p = 0.32). Twenty patients (46.5{\%}) had synchronous or metachronous cancers. Four patients died of hypopharyngeal cancer, and 5 died of second-primary esophageal cancer. Conclusions: A majority of patients with early hypopharyngeal cancer was curable. However, second malignancies influenced the overall outcome of patients with early hypopharyngeal cancer.",
author = "Katsumasa Nakamura and Yoshiyuki Shioyama and Tomonari Sasaki and Ohga Saiji and Madoka Saku and Yusuke Urashima and Tadamasa Yoshitake and Torahiko Nakashima and Yuichiro Kuratomi and Shizuo Komune and Hiromi Terashima and Hiroshi Honda",
year = "2005",
month = "7",
day = "1",
doi = "10.1016/j.ijrobp.2004.11.012",
language = "English",
volume = "62",
pages = "680--683",
journal = "International Journal of Radiation Oncology Biology Physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Chemoradiation therapy with or without salvage surgery for early squamous cell carcinoma of the hypopharynx

AU - Nakamura, Katsumasa

AU - Shioyama, Yoshiyuki

AU - Sasaki, Tomonari

AU - Saiji, Ohga

AU - Saku, Madoka

AU - Urashima, Yusuke

AU - Yoshitake, Tadamasa

AU - Nakashima, Torahiko

AU - Kuratomi, Yuichiro

AU - Komune, Shizuo

AU - Terashima, Hiromi

AU - Honda, Hiroshi

PY - 2005/7/1

Y1 - 2005/7/1

N2 - Purpose: Early squamous cell carcinoma of the hypopharynx is a rare clinical entity. Our objective was to analyze the outcome of patients with early hypopharyngeal cancer treated with curative radiotherapy or the combination of preoperative radiotherapy with surgery. Methods and Materials: Forty-three patients with Stage I-II hypopharyngeal cancer were initially treated with 30-40 Gy of irradiation with or without chemotherapy. Thirty-two patients (74.4%) who demonstrated a complete response continued to receive further radiotherapy, with a median total dose of 61.2 Gy. Eleven other patients (25.6%) received surgery. Results: Local control with laryngeal voice preservation was achieved in 8 (88.9%) of 9 patients with Stage I disease, and in 23 (67.6%) of 34 patients with Stage II disease. The overall and disease-specific 5-year survival rates for all patients were 70.4% and 89.5%, respectively. The disease-specific survival rates according to the T-category were 100% for patients with T1 disease and 87.2% for patients with T2 disease (p = 0.32). Twenty patients (46.5%) had synchronous or metachronous cancers. Four patients died of hypopharyngeal cancer, and 5 died of second-primary esophageal cancer. Conclusions: A majority of patients with early hypopharyngeal cancer was curable. However, second malignancies influenced the overall outcome of patients with early hypopharyngeal cancer.

AB - Purpose: Early squamous cell carcinoma of the hypopharynx is a rare clinical entity. Our objective was to analyze the outcome of patients with early hypopharyngeal cancer treated with curative radiotherapy or the combination of preoperative radiotherapy with surgery. Methods and Materials: Forty-three patients with Stage I-II hypopharyngeal cancer were initially treated with 30-40 Gy of irradiation with or without chemotherapy. Thirty-two patients (74.4%) who demonstrated a complete response continued to receive further radiotherapy, with a median total dose of 61.2 Gy. Eleven other patients (25.6%) received surgery. Results: Local control with laryngeal voice preservation was achieved in 8 (88.9%) of 9 patients with Stage I disease, and in 23 (67.6%) of 34 patients with Stage II disease. The overall and disease-specific 5-year survival rates for all patients were 70.4% and 89.5%, respectively. The disease-specific survival rates according to the T-category were 100% for patients with T1 disease and 87.2% for patients with T2 disease (p = 0.32). Twenty patients (46.5%) had synchronous or metachronous cancers. Four patients died of hypopharyngeal cancer, and 5 died of second-primary esophageal cancer. Conclusions: A majority of patients with early hypopharyngeal cancer was curable. However, second malignancies influenced the overall outcome of patients with early hypopharyngeal cancer.

UR - http://www.scopus.com/inward/record.url?scp=20344400112&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20344400112&partnerID=8YFLogxK

U2 - 10.1016/j.ijrobp.2004.11.012

DO - 10.1016/j.ijrobp.2004.11.012

M3 - Article

VL - 62

SP - 680

EP - 683

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

SN - 0360-3016

IS - 3

ER -