Chemoradiation therapy with or without salvage surgery for early squamous cell carcinoma of the hypopharynx

Katsumasa Nakamura, Yoshiyuki Shioyama, Tomonari Sasaki, Saiji Ohga, Madoka Saku, Yusuke Urashima, Tadamasa Yoshitake, Torahiko Nakashima, Yuichiro Kuratomi, Shizuo Komune, Hiromi Terashima, Hiroshi Honda

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose: Early squamous cell carcinoma of the hypopharynx is a rare clinical entity. Our objective was to analyze the outcome of patients with early hypopharyngeal cancer treated with curative radiotherapy or the combination of preoperative radiotherapy with surgery. Methods and Materials: Forty-three patients with Stage I-II hypopharyngeal cancer were initially treated with 30-40 Gy of irradiation with or without chemotherapy. Thirty-two patients (74.4%) who demonstrated a complete response continued to receive further radiotherapy, with a median total dose of 61.2 Gy. Eleven other patients (25.6%) received surgery. Results: Local control with laryngeal voice preservation was achieved in 8 (88.9%) of 9 patients with Stage I disease, and in 23 (67.6%) of 34 patients with Stage II disease. The overall and disease-specific 5-year survival rates for all patients were 70.4% and 89.5%, respectively. The disease-specific survival rates according to the T-category were 100% for patients with T1 disease and 87.2% for patients with T2 disease (p = 0.32). Twenty patients (46.5%) had synchronous or metachronous cancers. Four patients died of hypopharyngeal cancer, and 5 died of second-primary esophageal cancer. Conclusions: A majority of patients with early hypopharyngeal cancer was curable. However, second malignancies influenced the overall outcome of patients with early hypopharyngeal cancer.

Original languageEnglish
Pages (from-to)680-683
Number of pages4
JournalInternational Journal of Radiation Oncology Biology Physics
Volume62
Issue number3
DOIs
Publication statusPublished - Jul 1 2005

All Science Journal Classification (ASJC) codes

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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